Zobrazeno 1 - 10
of 20
pro vyhledávání: '"R M, Shull"'
Publikováno v:
Experimental hematology. 20(9)
The cDNA for canine stem cell factor (cSCF, c-kit ligand) was cloned and expressed in Escherichia coli. The recombinant protein (rcSCF), 165 amino acids in length, is very similar structurally to the soluble form of previously cloned and sequenced ro
Autor:
L J, Stoltzfus, B, Sosa-Pineda, S M, Moskowitz, K P, Menon, B, Dlott, L, Hooper, D B, Teplow, R M, Shull, E F, Neufeld
Publikováno v:
The Journal of biological chemistry. 267(10)
alpha-L-Iduronidase is a lysosomal enzyme, the deficiency of which causes mucopolysaccharidosis I (MPS I); a canine MPS I colony has been bred to test therapeutic intervention. The enzyme was purified to apparent homogeneity from canine testis and fo
Publikováno v:
American journal of veterinary research. 51(12)
Five dogs with mucopolysaccharidosis I, 3 of which had been treated with bone marrow transplantation (BMT), were evaluated for 20 months with electrocardiography, thoracic radiography, and M-mode and 2-dimensional echocardiography. Treated and untrea
Publikováno v:
Journal of Clinical Investigation. 79:435-443
Five dogs with mucopolysaccharidosis I, a model of human Hurler/Scheie syndrome, were transplanted with marrow from phenotypically normal littermates at 5 mo of age. At 3 and 9 mo posttransplantation, biopsies of cerebral cortex, liver, and cerebrosp
Autor:
R M, Shull, N E, Hastings
Publikováno v:
Clinical chemistry. 31(6)
We investigated measuring serum alpha-L-iduronidase (EC 3.2.1.76) by a sensitive fluorometric assay in 28 members of a canine family with mucopolysaccharidosis I. If assayed on the day of collection, serum was an acceptable specimen for identifying a
Publikováno v:
Journal of the American Veterinary Medical Association. 173(8)
Marked spiculation of red blood cells was observed in a young dog with severe hepatic disease. The resulting anemia was similar to spur cell anemia associated with hepatocellular disease in man. Though the exact cause of spur cell formation is not kn
Autor:
R M, Shull, D, Powell
Publikováno v:
The Cornell veterinarian. 69(3)
Hyposegmentation of granulocyte nuclei was diagnosed in an adult dog after unsuccessful attempt at finding an occult chronic infection. Intermittent signs of prostatitis were temporarily observed, but the immature nature of circulating granulocytes p
Publikováno v:
Investigative ophthalmologyvisual science. 30(8)
Corneal opacification associated with glycosaminoglycan (GAG) deposition occurs in canine mucopolysaccharidosis I (MPS I), a deficiency of the lysosomal enzyme alpha-L-iduronidase. In affected dogs corneal lesions appear similar to those in children
Publikováno v:
Acta neuropathologica. 75(6)
Morphological changes in neurons with inborn defects of the lysosomal hydrolase, alpha-L-iduronidase, and with concomitant storage of glycosaminoglycans, were evaluated by Golgi staining in two animal models and compared to a similar study of a child
Publikováno v:
American journal of veterinary research. 50(6)
The effects of canine parvovirus (CPV) infection in dogs with hemolytic anemia was compared with the clinical effects of human parvovirus-induced aplastic anemia in human beings with chronic regenerative anemias. Phenylhydrazine was used to induce a