Zobrazeno 1 - 10
of 12
pro vyhledávání: '"R M, Shaheen"'
Publikováno v:
Clinical Chemistry. 41:1585-1591
We evaluated cathepsin D concentrations in 318 breast carcinoma specimens with a standardized IRMA and established distribution values of 5.9-217.8 nmol/g (median 51.8). Concentrations of cathepsin D did not correlate with age or with concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc10267be432e7f7ba3f5603e8595eed
https://doi.org/10.1093/clinchem/41.11.1585
https://doi.org/10.1093/clinchem/41.11.1585
Publikováno v:
Oncology (Williston Park, N.Y.). 15(7 Suppl 8)
Angiogenesis is essential for the growth of both primary and metastatic tumors. This process, more complex than was previously thought, requires the coordinated activities of multiple factors and cell types. For tumors to develop a neovascular blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf5864fd62851d4a0cde4ef59d059536
https://pubmed.ncbi.nlm.nih.gov/11497231
https://pubmed.ncbi.nlm.nih.gov/11497231
Autor:
S A, Ahmad, W, Liu, Y D, Jung, F, Fan, M, Wilson, N, Reinmuth, R M, Shaheen, C D, Bucana, L M, Ellis
Publikováno v:
Cancer research. 61(4)
Angiopoietin (Ang) 1 and Ang-2 are important regulators of endothelial cell survival. Current models suggest that an increase in Ang-2 expression in endothelial cells leads to initiation of angiogenesis. We stably transfected HT29 colon cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a87dca1229e0bf5595c170cbf2b7a2f
https://pubmed.ncbi.nlm.nih.gov/11245414
https://pubmed.ncbi.nlm.nih.gov/11245414
Autor:
R M, Shaheen, W W, Tseng, D W, Davis, W, Liu, N, Reinmuth, R, Vellagas, A A, Wieczorek, Y, Ogura, D J, McConkey, K E, Drazan, C D, Bucana, G, McMahon, L M, Ellis
Publikováno v:
Cancer research. 61(4)
Redundant mechanisms mediate colon cancer angiogenesis. Targeting multiple angiogenic factors simultaneously may improve survival of mice with colon cancer metastases. BALB/c mice underwent splenic injection with CT-26 colon cancer cells to generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e699aef284d4368dea7e4526b002afd4
https://pubmed.ncbi.nlm.nih.gov/11245452
https://pubmed.ncbi.nlm.nih.gov/11245452
Publikováno v:
Apoptosis : an international journal on programmed cell death. 5(4)
Angiogenesis is essential for the growth and metastasis of solid tumors. The balance of endothelial cell (EC) proliferation and apoptosis is a major determinant in tumor angiogenesis. Recently, several studies demonstrated that numerous angiogenic fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3844c027487b64595dc4cea96c1e36ac
https://pubmed.ncbi.nlm.nih.gov/11227213
https://pubmed.ncbi.nlm.nih.gov/11227213
Autor:
R M, Shaheen, W W, Tseng, R, Vellagas, W, Liu, S A, Ahmad, Y D, Jung, N, Reinmuth, K E, Drazan, C D, Bucana, D J, Hicklin, L M, Ellis
Publikováno v:
International journal of oncology. 18(2)
Vascular endothelial growth factor (VEGF) is the predominant regulator of colon cancer angiogenesis and is associated with a poor prognosis and the development of metastases. We hypothesized that DC101, an antibody against the VEGF receptor-2 (flk-1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a43d40e534eee3f5eec4173c822cde8a
https://pubmed.ncbi.nlm.nih.gov/11172585
https://pubmed.ncbi.nlm.nih.gov/11172585
Autor:
C J, Bruns, W, Liu, D W, Davis, R M, Shaheen, D J, McConkey, M R, Wilson, C D, Bucana, D J, Hicklin, L M, Ellis
Publikováno v:
Cancer. 89(3)
Recent studies have suggested that vascular endothelial growth factor (VEGF), in addition to its proangiogenic properties, also functions as a survival factor for endothelial cells. The authors hypothesized that inhibition of VEGF activity by blockad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dcec7dd232fa1b649a2fb38ba70feaf5
https://pubmed.ncbi.nlm.nih.gov/10931447
https://pubmed.ncbi.nlm.nih.gov/10931447
Autor:
D B, Mendel, A D, Laird, B D, Smolich, R A, Blake, C, Liang, A L, Hannah, R M, Shaheen, L M, Ellis, S, Weitman, L K, Shawver, J M, Cherrington
Publikováno v:
Anti-cancer drug design. 15(1)
Angiogenesis, or the sprouting of new blood vessels, is a central process in the growth of solid tumors. For many cancers, the extent of vascularization of a tumor is a negative prognostic indicator signifying aggressive disease and increased potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b51cd58b87338fdd8465f3efa6c25cb
https://pubmed.ncbi.nlm.nih.gov/10888034
https://pubmed.ncbi.nlm.nih.gov/10888034
Autor:
R M, Shaheen, D W, Davis, W, Liu, B K, Zebrowski, M R, Wilson, C D, Bucana, D J, McConkey, G, McMahon, L M, Ellis
Publikováno v:
Cancer research. 59(21)
Increased vascular endothelial growth factor (VEGF) expression is associated with colon cancer metastases. We hypothesized that inhibition of VEGF receptor activity could inhibit colon cancer liver metastases. BALB/c mice underwent splenic injection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::123538099341bb597c2877f141a59ce5
https://pubmed.ncbi.nlm.nih.gov/10554007
https://pubmed.ncbi.nlm.nih.gov/10554007
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(11)
Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis and vascular permeability. We hypothesized that malignant pleural effusions may contain high levels of VEGF protein as well as other cytokines implicated in these proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a70558131233af8130825caf134902c0
https://pubmed.ncbi.nlm.nih.gov/10589746
https://pubmed.ncbi.nlm.nih.gov/10589746