Zobrazeno 1 - 10
of 63
pro vyhledávání: '"R M, Senior"'
Publikováno v:
Diabetologia. 46:1438-1445
Although matrix metalloproteinase-9 (MMP-9) is specifically induced and apoptosis of endothelial cells is evidenced in diabetes mellitus, the mechanism of endocardial endothelial dysfunction in diabetes mellitus is not clear. The increase in MMP-9 ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88658233d8d48c85a45a113ca4ad0b4d
https://doi.org/10.1007/s00125-003-1200-y
https://doi.org/10.1007/s00125-003-1200-y
Autor:
C. J. Fliszar, Gregory Goldberg, G. L. Griffin, R. M. Senior, Howard G. Welgus, Steven D. Shapiro
Publikováno v:
Journal of Biological Chemistry. 266:7870-7875
Elastin is critical to the structural integrity of a variety of connective tissues. Only a select group of enzymes has thus far been identified capable of cleaving insoluble elastin. Recently, we observed that human alveolar macrophages secrete elast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b715e0d439a66cdc3ab8ddeab80f8b5
https://doi.org/10.1016/s0021-9258(20)89530-1
https://doi.org/10.1016/s0021-9258(20)89530-1
Autor:
James C. Hogg, R M Senior
The pathology and pathogenesis of emphysema are reviewed, with particular reference to the proteinase-antiproteinase hypothesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378217ee0a151345e629ddf931f43b82
https://europepmc.org/articles/PMC1746435/
https://europepmc.org/articles/PMC1746435/
Publikováno v:
Chest. 116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64771165af8167e51488a79a37c64b78
https://pubmed.ncbi.nlm.nih.gov/10424565
https://pubmed.ncbi.nlm.nih.gov/10424565
Expression of laminin alpha3, alpha4, and alpha5 chains by alveolar epithelial cells and fibroblasts
Autor:
R A, Pierce, G L, Griffin, M S, Mudd, M A, Moxley, W J, Longmore, J R, Sanes, J H, Miner, R M, Senior
Publikováno v:
American journal of respiratory cell and molecular biology. 19(2)
Laminins are principal components of basement membranes. Eleven laminin isoforms are known, each a heterotrimer composed of polypeptide chains designated alpha, beta, and gamma. Five alpha chains have been identified to date: alpha1, alpha2, alpha3,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77d4f0877b024ec53a0e1695ee0252bb
https://pubmed.ncbi.nlm.nih.gov/9698595
https://pubmed.ncbi.nlm.nih.gov/9698595
Publikováno v:
The Journal of biological chemistry. 272(29)
Insoluble elastin was used as a substrate to characterize the peptide bond specificities of human (HME) and mouse macrophage elastase (MME) and to compare these enzymes with other mammalian metalloproteinases and serine elastases. New amino termini d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::841983b8bc89c3dacc08b28a2edf10f5
https://pubmed.ncbi.nlm.nih.gov/9218437
https://pubmed.ncbi.nlm.nih.gov/9218437
Publikováno v:
The Journal of biological chemistry. 271(48)
Extracellular matrix proteins activate neutrophils to up-regulate many physiologic functions that are necessary at sites of tissue injury. To elucidate the ligand-receptor interactions that mediate these functions, we examined neutrophil activation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6848c2231986faf04e90ca923a5e05ef
https://pubmed.ncbi.nlm.nih.gov/8940031
https://pubmed.ncbi.nlm.nih.gov/8940031
Publikováno v:
The Journal of biological chemistry. 270(11)
The matrix metalloproteinase 92-kDa gelatinase is a major product of inflammatory cells. Macrophages synthesize and secrete this proteinase as a proenzyme in association with tissue inhibitor of metalloproteinases (TIMP) (92TIMP), whereas neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a1357f6b6999e88c1e0095956df3c40
https://pubmed.ncbi.nlm.nih.gov/7890773
https://pubmed.ncbi.nlm.nih.gov/7890773
Publikováno v:
Ciba Foundation symposium. 192
Elastic fibres are present in lung structures including alveoli, alveolar ducts, airways, vasculature and pleura. The rate of lung elastin synthesis is greatest during fetal and neonatal development, and is minimal in the healthy adult. We have deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c991d72a5f7c35a8d423104682e2bad1
https://pubmed.ncbi.nlm.nih.gov/8575258
https://pubmed.ncbi.nlm.nih.gov/8575258
Autor:
U I, Sires, G L, Griffin, T J, Broekelmann, R P, Mecham, G, Murphy, A E, Chung, H G, Welgus, R M, Senior
Publikováno v:
The Journal of biological chemistry. 268(3)
Entactin is the basement membrane protein which bridges laminin and type IV collagen. Entactin is known to be degraded by serine proteinases, but its susceptibility to matrix metalloproteinases has not been determined. We have studied the capacity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e62a2b0fc2ce27ad114640ba7596fec2
https://pubmed.ncbi.nlm.nih.gov/8380588
https://pubmed.ncbi.nlm.nih.gov/8380588