Zobrazeno 1 - 10
of 24
pro vyhledávání: '"R M, Muccitelli"'
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(1)
PGD2, the predominant prostanoid released from activated human lung mast cells, is metabolized to 9 alpha, 11 beta-PGF2 by an 11-ketoreductase. Both prostanoids contract mammalian airway smooth muscle. In the present study, aerosol administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e8f14ed1a5313444a71dc937feec1ff
https://pubmed.ncbi.nlm.nih.gov/8301572
https://pubmed.ncbi.nlm.nih.gov/8301572
Publikováno v:
Prostaglandins. 33:651-661
Guinea-pig tracheal strip preparations containing cartilage, placed under an applied load in vitro, develop tone spontaneously. The finding that spontaneous tone is reduced by indomethacin suggests that one or more prostanoids are involved in the dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f27d0d244bd9c01019143d26087d18
https://doi.org/10.1016/0090-6980(87)90032-3
https://doi.org/10.1016/0090-6980(87)90032-3
Autor:
R. M. Muccitelli, Stephen G. Farmer, D.W.P. Hay, Karen A. Wilson, David Raeburn, Jeffrey S. Fedan
Publikováno v:
British Journal of Pharmacology. 92:381-388
1 The influence of the epithelium on contractions produced by the peptidoleukotrienes, 5-hydroxytryptamine (5-HT) and the thromboxane mimetic, U-44069, was examined in trachea from control and ovalbumin-sensitized guinea-pigs. 2 In control tissues re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4b486bad2095534d24277825e3a24f
https://doi.org/10.1111/j.1476-5381.1987.tb11334.x
https://doi.org/10.1111/j.1476-5381.1987.tb11334.x
Autor:
M A Wasserman, Barry M. Weichman, Jeris F. DeVan, Lynne M. Vickery, Stephanie S. Tucker, R. M. Muccitelli
Publikováno v:
Prostaglandins, Leukotrienes and Medicine. 15:167-175
SKF 88046 preferentially antagonized the contractions elicited by the functional thromboxane (Tx) A2 mimics and structural endoperoxide analogs, U-44069 and U-46619, on the guinea pig trachea. This concentration-dependent antagonism was described by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74476ba6e0781544496162dc0cfac922
https://doi.org/10.1016/0262-1746(84)90174-4
https://doi.org/10.1016/0262-1746(84)90174-4
Autor:
L. M. Vickery, R. M. Muccitelli, M A Wasserman, S. S. Tucker, Erhard Kf, J. F. Devan, Irene N. Uzinskas, John G. Gleason, M. E. Mccarthy, Carl D. Perchonock
Publikováno v:
Journal of Medicinal Chemistry. 29:1442-1452
A series of 5-alkynyl- and 5-aryl-4,6-dithianonanedioic acids and related compounds has been prepared for evaluation of leukotriene antagonist activity. The alkynyl compounds were prepared by thioacetal exchange from the corresponding acetylenic acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dead8941f770109bad4a3c67c37279a
https://doi.org/10.1021/jm00158a021
https://doi.org/10.1021/jm00158a021
Publikováno v:
Prostaglandins. 28:611-613
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398cfea719d5fb83566173ba928d248b
https://doi.org/10.1016/0090-6980(84)90132-1
https://doi.org/10.1016/0090-6980(84)90132-1
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 222(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78bc3a3f511632a70f2533e57ca68550
https://pubmed.ncbi.nlm.nih.gov/6283068
https://pubmed.ncbi.nlm.nih.gov/6283068
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 244(1)
To assimilate information about the relative efficacies and affinities of the peptidoleukotrienes, the ability of the beta adrenoceptor agonist salbutamol to antagonize functionally contractions produced by leukotrienes (LT)C4, LTD4 and LTE4 was exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb86b6cd5953d5b5e0324ce1d09a561a
https://pubmed.ncbi.nlm.nih.gov/2826775
https://pubmed.ncbi.nlm.nih.gov/2826775
Publikováno v:
Prostaglandins. 26(2)
Leukotriene D4 (LTD4) administered intravenously to anesthetized, spontaneously breathing guinea pigs elicited decreases in dynamic lung compliance (Cdyn) and airway conductance (GAW) with a maximal response achieved at 0.5 min. Simultaneously, plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8788133a4c53b0f55ce6cb95aadcfc
https://pubmed.ncbi.nlm.nih.gov/6689082
https://pubmed.ncbi.nlm.nih.gov/6689082
Publikováno v:
European journal of pharmacology. 126(3)
In the presence of l-serine borate, salbutamol was much more effective in reversing rather than preventing LTC 4 -induced contractions of guinea-pig trachea. This suggests that different mechanisms are involved in initiating versus maintaining LTC 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a35f130ded5508992c334914ab8203a
https://pubmed.ncbi.nlm.nih.gov/3093250
https://pubmed.ncbi.nlm.nih.gov/3093250