Zobrazeno 1 - 10
of 44
pro vyhledávání: '"R M, Minchinton"'
Autor:
Sara Diab, Kimble R. Dunster, Chris Anstey, R. M. Minchinton, Margaret R. Passmore, Yoke Lin Fung, Charles McDonald, Kiran Shekar, Gabriela Simonova, John F. Fraser, Samuel R. Foley, John-Paul Tung
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 311:L1202-L1212
Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment for patients with severe refractory cardiorespiratory failure. Exposure to the ECMO circuit is thought to trigger/exacerbate inflammation. Determining whether inflammation is the r
Publikováno v:
ISBT Science Series. 9:287-293
Background The last 20 years have seen substantial international efforts to minimize the incidence and risk of transfusion-related acute lung injury (TRALI). Nevertheless, TRALI remains a real morbidity and mortality risk to transfusion recipients. D
Publikováno v:
ISBT Science Series. 9:253-257
Background Neutrophils or polymorphonuclear neutrophils (PMNs) make up the largest proportion (45 – 70%) of circulating leukocytes and play a pivotal role in innate immunity. Thus, patients with low PMN counts (neutropenia) or defective PMN functio
Autor:
R. M. Minchinton, Yoke Lin Fung
Publikováno v:
Vox Sanguinis. 101:1-38
Autor:
R. M. Minchinton, Yoke Lin Fung
Publikováno v:
ISBT Science Series. 6:381-386
Background The neutrophil population makes up the largest proportion (40–70%) of white blood cells and is crucial to our innate immune response. An unexpectedly significant proportion of neutrophils (∼28%) is located in the pulmonary circulation.
Publikováno v:
ISBT Science Series. 6:416-421
Transfusion-related acute lung injury (TRALI) is a serious transfusion complication that may lead to significant morbidity and mortality. This has driven a significant research effort focused on understanding why and how TRALI develops. The ultimate
Publikováno v:
Vox Sanguinis. 101:282-290
Background and Objectives Severe transfusion-related acute lung injury (TRALI) events have been linked to donor-derived neutrophil antibodies. The journey to developing mass donor neutrophil antibody screening platforms is challenged by the fragility
Autor:
Slavica Vuckovic, Damon P. Eisen, Derek N.J. Hart, Melinda M. Dean, Robert L. Flower, R. M. Minchinton
Publikováno v:
Immunology. 132:296-305
Mannose-binding lectin (MBL) is a serum lectin that plays a significant role in innate host defence. Individuals with mutations in exon 1 of the MBL2 gene have reduced MBL ligand binding and complement activation function and increased incidence of i
Publikováno v:
Journal of Critical Care. 23:542-549
Purpose: To study the effects of systemic inflammatory response syndrome (SIRS) on polymorhonuclear neutrophil (PMN) function and phenotype by comparing neutrophils from critically ill patients with SIRS against those from healthy blood donors. Mater
Publikováno v:
Vox Sanguinis. 87:30-34