Výsledky vyhledávání - "R M, McGovern"

Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites

Autor: E C, Thorland, S L, Myers, D H, Persing, G, Sarkar, R M, McGovern, B S, Gostout, D I, Smith

Publikováno v: Cancer research. 60(21)

The development of cervical cancer is highly associated with human papillomavirus (HPV) infection. HPV integration into the genome of infected cervical cells is temporally associated with the acquisition of the malignant phenotype. A relationship bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::227b36129d754e9bce352fdb56161649
https://pubmed.ncbi.nlm.nih.gov/11085503

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Molecular epidemiology of breast cancers in northern and southern Japan: the frequency, clustering, and patterns of p53 gene mutations differ among these two low-risk populations

Autor: H, Blaszyk, A, Hartmann, Y, Tamura, S, Saitoh, J M, Cunningham, R M, McGovern, J J, Schroeder, D J, Schaid, K, Ii, Y, Monden, T, Morimoto, K, Komaki, M, Sasa, K, Hirata, M, Okazaki, J S, Kovach, S S, Sommer

Publikováno v: Oncogene. 13(10)

Comparison of acquired mutations in the p53 tumor suppressor gene can illuminate factors contributing to carcinogenesis among cancer cohorts. Japan has an ethnically homogeneous population with a low incidence of breast cancer. Previously we reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0f4c7a2fbe374669b349570ed7b0f17
https://pubmed.ncbi.nlm.nih.gov/8950983

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Overexpression and mutations of p53 in metastatic malignant melanomas

Autor: A, Hartmann, H, Blaszyk, J S, Cunningham, R M, McGovern, J S, Schroeder, S D, Helander, M R, Pittelkow, S S, Sommer, J S, Kovach

Publikováno v: International journal of cancer. 67(3)

Alterations of the p53 tumor suppressor gene are the most frequent genetic abnormalities in human malignancies, but the role of p53 in the etiology of malignant melanomas is unclear. Fifty unselected malignant melanomas were analyzed for p53 overexpr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5b116fdc51594f66836e345e608d029
https://pubmed.ncbi.nlm.nih.gov/8707401

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p53 gene mutations inside and outside of exons 5-8: the patterns differ in breast and other cancers

Autor: A, Hartmann, H, Blaszyk, R M, McGovern, J J, Schroeder, J, Cunningham, E M, De Vries, J S, Kovach, S S, Sommer

Publikováno v: Oncogene. 10(4)

Most studies of mutations in the p53 tumor suppressor gene in tumors have examined only exons 5-8. Our laboratory previously found 64 mutations in exons 5-8 of the p53 gene in 194 primary breast cancers. Herein, we report 18 additional mutations foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c60532d4240d2487b6debdfda4e7b65
https://pubmed.ncbi.nlm.nih.gov/7862445

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p53 gene mutations in breast cancers in midwestern US women: null as well as missense-type mutations are associated with poor prognosis

Autor: S, Saitoh, J, Cunningham, E M, De Vries, R M, McGovern, J J, Schroeder, A, Hartmann, H, Blaszyk, L E, Wold, D, Schaid, S S, Sommer

Publikováno v: Oncogene. 9(10)

We determined the pattern of mutations in exons 2-11 and adjacent intronic regions in breast cancers from Midwestern US white women. Twenty-one mutations were detected in 53 tumors (39.6%). Comparisons of the pattern of mutations within exons 5-9 sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3be26960271af482afb721503141b867
https://pubmed.ncbi.nlm.nih.gov/8084591

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Direct sequencing from touch preparations of human carcinomas: analysis of p53 mutations in breast carcinomas

Autor: J S, Kovach, R M, McGovern, J D, Cassady, S K, Swanson, L E, Wold, B, Vogelstein, S S, Sommer

Publikováno v: Journal of the National Cancer Institute. 83(14)

A new technique for characterizing somatic mutations in very small samples of cellularly heterogeneous human cancer tissue was developed and tested using mutations in the p53 gene in breast carcinomas as a model system. The technique combines touch p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9fdaee9eb2846e364138ed476fe6737
https://pubmed.ncbi.nlm.nih.gov/2072413

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