Zobrazeno 1 - 10
of 35
pro vyhledávání: '"R M, Flügel"'
Publikováno v:
Journal of Virology. 73:7907-7911
Spumaviruses, or foamy viruses, express Gag proteins that are incompletely processed by the viral protease in cell cultures. To delineate the proteolytic cleavage sites between potential Gag subdomains, recombinant human spumaretrovirus (HSRV) Gag pr
Endonucleolytic cleavages and DNA-joining activities of the integration protein of human foamy virus
Autor:
A Pahl, R M Flügel
Publikováno v:
Journal of Virology. 67:5426-5434
The bacterial expression plasmids, pET3b and pET16b, that contain the integrase domain of the human foamy virus (HFV) reverse transcriptase were constructed and expressed in Escherichia coli. The histidine-tagged HFV IN protein was purified to near h
Publikováno v:
Journal of Virology. 65:2589-2594
The human foamy viruses, or spumaviruses, a distinct subfamily of complex human retroviruses, remain poorly understood both in terms of their pathogenic potential and in terms of the regulatory mechanisms that govern their replication. Here, we demon
Autor:
R M, Flügel, K I, Pfrepper
Publikováno v:
Current topics in microbiology and immunology. 277
The foamy viral proteases (FV PRs) are set apart from other retroviral processing enzymes by unique features. The first remarkable property is that FV PRs are enzymatically active as high-molecular-mass Pro-Pol proteins. Hence there exist multiple fo
Autor:
K.-I. Pfrepper, R. M. Flügel
Publikováno v:
Foamy Viruses ISBN: 9783642629341
The foamy viral proteases (FV PRs) are set apart from other retroviral processing enzymes by unique features. The first remarkable property is that FV PRs are enzymatically active as high-molecular-mass Pro-Pol proteins. Hence there exist multiple fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2671ef2dad7752533ad0ae0ec2f17ea
https://doi.org/10.1007/978-3-642-55701-9_3
https://doi.org/10.1007/978-3-642-55701-9_3
Publikováno v:
Virus genes. 22(1)
Oligopeptides that correspond to proteolytic cleavage site junctions of the native Gag and Pol proteins are specifically cleaved by retroviral aspartate proteases (PRs). The role of the flap subdomain of the PR of the human spumaretrovirus (HSRV) and
Publikováno v:
Virus genes. 21(3)
Recombinant plasmids that express human foamy virus (HFV) Bel 1 transactivator and human estrogen receptor (ER) fusion proteins were constructed. The HFV bel 1 gene was inserted up- and downstream of the ER gene. Recombinant Bel 1-ER and ER-Bel 1 fus
Publikováno v:
Vox sanguinis. 79(2)
Publikováno v:
Virus genes. 15(1)
Deletion analyses of the long terminal repeat (LTR) and internal promoters (IP) of human foamy virus (HFV) showed that a negative acting element resides in the U5 region of the 5' LTR reducing reporter gene expression tenfold. The basal activity of t
Autor:
M Löchelt, R M Flügel
Publikováno v:
Journal of virology. 70(2)
It has been reported recently that the human foamy virus (HFV) Pol polyprotein of 120 kDa is synthesized in the absence of the active HFV aspartic protease. To gain more information on how the 120-kDa Pro-Pol protein is synthesized, mutant HFV genome