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Publikováno v: npj Digital Medicine, Vol 3, Iss 1, Pp 1-7 (2020)

Abstract Clinical trials are a fundamental tool used to evaluate the efficacy and safety of new drugs and medical devices and other health system interventions. The traditional clinical trials system acts as a quality funnel for the development and i

Externí odkaz: https://doaj.org/article/74588ba7851c4d4086f8aa8b6b55488d

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Digitizing clinical trials

Publikováno v: NPJ Digital Medicine
npj Digital Medicine, Vol 3, Iss 1, Pp 1-7 (2020)
NPJ digital medicine, vol 3, iss 1

Clinical trials are a fundamental tool used to evaluate the efficacy and safety of new drugs and medical devices and other health system interventions. The traditional clinical trials system acts as a quality funnel for the development and implementa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920a5398841cd4da9e9ecf4fd60fddb3
https://doi.org/10.1038/s41746-020-0302-y

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Metabolic syndrome and alanine aminotransferase: a global perspective from the NAVIGATOR screening population

Autor: M A, Bethel, P, Deedwania, N S, Levitt, O, Schmitz, A, Huntsman-Labed, R M, Califf, S M, Haffner, P, Diem

Publikováno v: Diabetic medicine : a journal of the British Diabetic Association. 26(12)

Non-alcoholic fatty liver disease (NAFLD) is associated with features of the metabolic syndrome (MetS) and may be an expression of the syndrome within the liver. Using screening data from the Nateglinide And Valsartan in Impaired Glucose Tolerance Ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::63fc24959d68320741909853d5b76d5c
https://pubmed.ncbi.nlm.nih.gov/20002471

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Effect of hirudin vs heparin on haemostatic activity in patients with acute coronary syndromes; the GUSTO-IIb haemostasis substudy

Autor: K, Kottke-Marchant, M C, Bahit, C B, Granger, P, Zoldhelyi, D, Ardissino, L, Brooks, J H, Griffin, R F, Potthoff, F, Van de Werf, R M, Califf, E J, Topol

Publikováno v: European heart journal. 23(15)

We compared the effects of hirudin and heparin on thrombin generation and activity among 350 patients with acute coronary syndromes enrolled in the GUSTO-IIb trial.We obtained blood at baseline; at 4, 8, and 24h into infusion; at drug termination; an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::240b50c0113aae43620a320870100288
https://pubmed.ncbi.nlm.nih.gov/12127916

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Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial

Autor: R J, Dolor, D L, Witsell, A S, Hellkamp, J W, Williams, R M, Califf, D L, Simel

Publikováno v: JAMA. 286(24)

It is not known whether intranasal corticosteroids are beneficial to treat acute rhinosinusitis in patients with a history of chronic or recurrent sinus symptoms.To assess whether the addition of an intranasal corticosteroid to antibiotic therapy aff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ede59710161924f29d025f267bd06cf
https://pubmed.ncbi.nlm.nih.gov/12093213

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Prognostic value of ST segment depression in acute coronary syndromes: insights from PARAGON-A applied to GUSTO-IIb. PARAGON-A and GUSTO IIb Investigators. Platelet IIb/IIIa Antagonism for the Reduction of Acute Global Organization Network

Autor: P, Kaul, Y, Fu, W C, Chang, R A, Harrington, G S, Wagner, S G, Goodman, C B, Granger, D J, Moliterno, F, Van de Werf, R M, Califf, E J, Topol, P W, Armstrong

Publikováno v: Journal of the American College of Cardiology. 38(1)

Our objectives were to develop a risk-stratification model addressing the importance of the magnitude and distribution of ST segment depression in predicting long-term outcomes and to validate the model in an analogous patient population.Although pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb6c67110deb53915f20e929a95018fc
https://pubmed.ncbi.nlm.nih.gov/11451297

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