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Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin-ethanolamides) in the feline iris

Autor: Craig Struble, Yariv Donde, Yanbin Liang, R. M. Burk, Charles E. Protzman, Achim H.-P. Krauss, D.F. Woodward, Jenny W. Wang, K Landsverk, A.L. Nieves

Publikováno v: British Journal of Pharmacology. 150:342-352

Background and Purpose: The prostamides (prostaglandin-ethanolamides) and prostaglandin (PG) glyceryl esters are biosynthesized by COX-2 from the respective endocannabinoids anandamide and 2-arachidonyl glycerol. Agonist studies suggest that their ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42debd866bc5b2e134d09e0832ab305f
https://doi.org/10.1038/sj.bjp.0706989

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Replacement of the carboxylic acid group of prostaglandin F2αwith a hydroxyl or methoxy substituent provides biologically unique compounds

Publikováno v: British Journal of Pharmacology. 130:1933-1943

Replacement of the carboxylic acid group of PGF(2alpha) with the non-acidic substituents hydroxyl (-OH) or methoxy (-OCH(3)) resulted in an unexpected activity profile. Although PGF(2alpha) 1-OH and PGF(2alpha) 1-OCH(3) exhibited potent contractile e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4db77a4e459e159e2b98cf72dd45616b
https://doi.org/10.1038/sj.bjp.0703462

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Structure-Activity Relationships of C1 and C6 Side Chains of Zaragozic Acid A Derivatives

Autor: R M Burk, Robert W. Marquis, K F Bartizal, Mitree M. Ponpipom, C D Roberts, Nirindar N Girotra, Gregory D. Berger, J D Bergstom, William H. Parsons, Robert L. Bugianesi

Publikováno v: Journal of Medicinal Chemistry. 37:4031-4051

Systematic modification of the C6 acyl side chain of zaragozic acid A, a potent squalene synthase inhibitor, was undertaken to improve its biological activity. Simplification of the C6 side chain to the octanoyl ester has deleterious effects; increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a661770f16d2de0b99016eb04fe519
https://doi.org/10.1021/jm00049a022

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Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin-ethanolamides) in the feline iris

Autor: D F, Woodward, A H, Krauss, J W, Wang, C E, Protzman, A L, Nieves, Y, Liang, Y, Donde, R M, Burk, K, Landsverk, C, Struble

Publikováno v: British journal of pharmacology. 150(3)

The prostamides (prostaglandin-ethanolamides) and prostaglandin (PG) glyceryl esters are biosynthesized by COX-2 from the respective endocannabinoids anandamide and 2-arachidonyl glycerol. Agonist studies suggest that their pharmacologies are unique

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b317d8cfea67030439740591068808c
https://pubmed.ncbi.nlm.nih.gov/17179945

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Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism

Autor: Filomena Fezza, T. Bisogno, Isabel Matias, V. Di Marzo, Alessia Ligresti, R. M. Burk, Yanbin Liang, Chen Li, Karen M. Kedzie, June Chen, Achim H.-P. Krauss, A.L. Nieves, Licheng Shi, David F. Woodward, L. De Petrocellis, Charles E. Protzman

Publikováno v: The Journal of pharmacology and experimental therapeutics
309 (2004): 745–757. doi:10.1124/jpet.103.061705
info:cnr-pdr/source/autori:Matias I, Chen J, De Petrocellis L, Bisogno T, Ligresti A, Fezza F, Krauss AH, Shi L, Protzman CE, Li C, Liang Y, Nieves AL, Kedzie KM, Burk RM, Di Marzo V, Woodward DF./titolo:Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism./doi:10.1124%2Fjpet.103.061705/rivista:The Journal of pharmacology and experimental therapeutics (Print)/anno:2004/pagina_da:745/pagina_a:757/intervallo_pagine:745–757/volume:309
(2004).
info:cnr-pdr/source/autori:Matias I, Chen J, De Petrocellis L, Bisogno T, Ligresti A, Fezza F, Krauss AH, Shi L, Protzman CE, Li C, Liang Y, Nieves AL, Kedzie KM, Burk RM, Di Marzo V, Woodward DF./titolo:Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism./doi:/rivista:The Journal of pharmacology and experimental therapeutics (Print)/anno:2004/pagina_da:/pagina_a:/intervallo_pagine:/volume

We investigated whether prostaglandin ethanolamides (prostamides) E(2), F(2alpha), and D(2) exert some of their effects by 1) activating prostanoid receptors either per se or after conversion into the corresponding prostaglandins; 2) interacting with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b535cc10c39bd5637d09333513bc6d7
http://www.cnr.it/prodotto/i/167314

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