Zobrazeno 1 - 10
of 141
pro vyhledávání: '"R Luise Krauth-Siegel"'
Publikováno v:
eLife, Vol 9 (2020)
Trypanosomes have a trypanothione redox metabolism that provides the reducing equivalents for numerous essential processes, most being mediated by tryparedoxin (Tpx). While the biosynthesis and reduction of trypanothione are cytosolic, the molecular
Externí odkaz:
https://doaj.org/article/58b502bb4d7e454090767e23db0aa818
Autor:
Rachel B Currier, Kathrin Ulrich, Alejandro E Leroux, Natalie Dirdjaja, Matías Deambrosi, Mariana Bonilla, Yasar Luqman Ahmed, Lorenz Adrian, Haike Antelmann, Ursula Jakob, Marcelo A Comini, R Luise Krauth-Siegel
Publikováno v:
PLoS Pathogens, Vol 15, Iss 9, p e1008065 (2019)
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved cysteine residues to catalyze thiol-disulfide exchange reactions. Here we demonstrate that the so far unexplored Trx2 from African trypanosomes (Tryp
Externí odkaz:
https://doaj.org/article/760db50775bb44a9a0ccbc05aa1486bd
Autor:
Marta Bogacz, R Luise Krauth-Siegel
Publikováno v:
eLife, Vol 7 (2018)
Tryparedoxin peroxidases, distant relatives of glutathione peroxidase 4 in higher eukaryotes, are responsible for the detoxification of lipid-derived hydroperoxides in African trypanosomes. The lethal phenotype of procyclic Trypanosoma brucei that la
Externí odkaz:
https://doaj.org/article/a877a3abb2a74796933b82252f0da560
Autor:
Mathias Beig, Frank Oellien, Linnéa Garoff, Sandra Noack, R Luise Krauth-Siegel, Paul M Selzer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003773 (2015)
With the goal to identify novel trypanothione reductase (TR) inhibitors, we performed a combination of in vitro and in silico screening approaches. Starting from a highly diverse compound set of 2,816 compounds, 21 novel TR inhibiting compounds could
Externí odkaz:
https://doaj.org/article/463f349fba974068be48d4dabecdaafa
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004075 (2014)
African trypanosomes express three virtually identical non-selenium glutathione peroxidase (Px)-type enzymes which preferably detoxify lipid-derived hydroperoxides. As shown previously, bloodstream Trypanosoma brucei lacking the mitochondrial Px III
Externí odkaz:
https://doaj.org/article/6c8c5445420e4d9ea275f77767efe4e8
Autor:
Alonzo González-González, Oscar Sánchez-Sánchez, R. Luise Krauth-Siegel, Maria Laura Bolognesi, Rogelio Gớmez-Escobedo, Benjamín Nogueda-Torres, Lenci K. Vázquez-Jiménez, Emma Saavedra, Rusely Encalada, José Carlos Espinoza-Hicks, Alma D. Paz-González, Gildardo Rivera
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13315
American trypanosomiasis is a worldwide health problem that requires attention due to ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives against trypomastigotes of the Trypanosoma cru
Autor:
Thien Anh Le, Natalie Dirdjaja, Erika Diehl, Martha Brennich, Till Opatz, Philipp Klein, Nicole Bader, Bernd Engels, Ute A. Hellmich, A. Katharina Weickhmann, Annika Wagner, Hermann Schindelin, Daniel Paszek, R. Luise Krauth-Siegel
Publikováno v:
Angewandte Chemie. 131:3679-3683
Autor:
Bernhard Wünsch, R. Luise Krauth-Siegel, Marcel Kaiser, Valquíria A. P. Jabor, Thomas J. Schmidt, Kirstin Lehmkuhl, Frederik Börgel, Maria Cristina Nonato, Dirk Schepmann, Jan-Frederik Uth
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Herein, relationships between the structures of 1-aminoethyl-substituted chromenes and their antimalarial activities were thoroughly investigated. At first, the methyl moiety in the side chain was removed to eliminate chirality. The hydrogenation sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe66ab5f7e7b353b8a514f78b4071c8
Publikováno v:
Redox Biology
Redox Biology, Vol 34, Iss, Pp 101547-(2020)
Redox Biology, Vol 34, Iss, Pp 101547-(2020)
Hydroperoxide reduction in African trypanosomes relies on 2-Cys-peroxiredoxins (Prxs) and glutathione peroxidase-type enzymes (Pxs) which both obtain their reducing equivalents from the trypanothione/tryparedoxin couple and thus act as tryparedoxin p