Zobrazeno 1 - 10
of 134
pro vyhledávání: '"R Liem"'
Autor:
Joseph M Replogle, Jessica L Bonnar, Angela N Pogson, Christina R Liem, Nolan K Maier, Yufang Ding, Baylee J Russell, Xingren Wang, Kun Leng, Alina Guna, Thomas M Norman, Ryan A Pak, Daniel M Ramos, Michael E Ward, Luke A Gilbert, Martin Kampmann, Jonathan S Weissman, Marco Jost
Publikováno v:
eLife, Vol 11 (2022)
CRISPR interference (CRISPRi) enables programmable, reversible, and titratable repression of gene expression (knockdown) in mammalian cells. Initial CRISPRi-mediated genetic screens have showcased the potential to address basic questions in cell biol
Externí odkaz:
https://doaj.org/article/af03cd98b4f34c128b98cd963fa2ba56
Autor:
Smriti Parashar, Ravi Chidambaram, Shuliang Chen, Christina R Liem, Eric Griffis, Gerard G Lambert, Nathan C Shaner, Matthew Wortham, Jesse C Hay, Susan Ferro-Novick
Publikováno v:
eLife, Vol 10 (2021)
The endoplasmic reticulum (ER) is composed of sheets and tubules. Here we report that the COPII coat subunit, SEC24C, works with the long form of the tubular ER-phagy receptor, RTN3, to target dominant-interfering mutant proinsulin Akita puncta to ly
Externí odkaz:
https://doaj.org/article/bfdc35449f78485fab17dbdda6923c5b
Autor:
Sandra Elizabeth Torres, Ciara M Gallagher, Lars Plate, Meghna Gupta, Christina R Liem, Xiaoyan Guo, Ruilin Tian, Robert M Stroud, Martin Kampmann, Jonathan S Weissman, Peter Walter
Publikováno v:
eLife, Vol 8 (2019)
The unfolded protein response (UPR) detects and restores deficits in the endoplasmic reticulum (ER) protein folding capacity. Ceapins specifically inhibit the UPR sensor ATF6α, an ER-tethered transcription factor, by retaining it at the ER through a
Externí odkaz:
https://doaj.org/article/1385a79477e045e0a8efc889a4a6ac9d
Autor:
Angela N Pogson, Jessica L Bonnar, Joseph M Replogle, Christina R Liem, Nolan K Maier, Yufang Ding, Baylee J Russell, Xingren Wang, Kun Leng, Alina Guna, Thomas M Norman, Ryan A Pak, Daniel M Ramos, Michael E Ward, Luke A Gilbert, Martin Kampmann, Jonathan S Weissman, Marco Jost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e7d2d97d229edac14829d4e3858e296
https://doi.org/10.7554/elife.81856.sa2
https://doi.org/10.7554/elife.81856.sa2
Autor:
Joseph M. Replogle, Jessica L. Bonnar, Angela N. Pogson, Christina R. Liem, Nolan K. Maier, Yufang Ding, Baylee J. Russell, Xingren Wang, Kun Leng, Alina Guna, Thomas M. Norman, Ryan A. Pak, Daniel M. Ramos, Michael E. Ward, Luke A. Gilbert, Martin Kampmann, Jonathan S. Weissman, Marco Jost
CRISPR interference (CRISPRi) enables programmable, reversible, and titratable repression of gene expression (knockdown) in mammalian cells. Initial CRISPRi-mediated genetic screens have showcased the potential to address basic questions in cell biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdf7ca55256386579b422055fd4e823
https://doi.org/10.1101/2022.07.13.499814
https://doi.org/10.1101/2022.07.13.499814
Akademický článek
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Autor:
Bhairavi Tolani, Anna Celli, Yanmin Yao, Yong Zi Tan, Richard Fetter, Christina R. Liem, Adam J. de Smith, Thamiya Vasanthakumar, Paola Bisignano, Adam D. Cotton, Ian B. Seiple, John L. Rubinstein, Marco Jost, Jonathan S. Weissman
Publikováno v:
Nature biotechnology, vol 40, iss 12
Mutations in Ras family proteins are implicated in 33% of human cancers, but direct pharmacological inhibition of Ras mutants remains challenging. As an alternative to direct inhibition, we screened for sensitivities in Ras-mutant cells and discovere
Autor:
Matthew Wortham, Eric R. Griffis, Susan Ferro-Novick, Smriti Parashar, Ravi Chidambaram, Shuliang Chen, Christina R Liem, Gerard G. Lambert, Nathan C. Shaner, Jesse C. Hay
Publikováno v:
eLife, Vol 10 (2021)
The endoplasmic reticulum (ER) is composed of sheets and tubules. Here we report that the COPII coat subunit, SEC24C, works with the long form of the tubular ER-phagy receptor, RTN3, to target dominant-interfering mutant proinsulin Akita puncta to ly
Autor:
Nathan C. Shaner, Gerard G. Lambert, Shuliang Chen, Eric R. Griffis, Matthew Wortham, Jesse C. Hay, Ravi Chidambaram, Smriti Parashar, Susan Ferro-Novick, Christina R Liem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::041a945121b006d5cd3aec582a62f707
https://doi.org/10.7554/elife.71642.sa2
https://doi.org/10.7554/elife.71642.sa2
Autor:
Susana A. Ribeiro, Xiaowei Yan, Max A. Horlbeck, Marvin E. Tanenbaum, Ronald D. Vale, Marco Jost, Jonathan S. Weissman, Christina R. Liem, Nico Stuurman
Publikováno v:
The Journal of cell biology, vol 220, iss 2
The Journal of Cell Biology
Journal of Cell Biology, 220(2). Rockefeller University Press
The Journal of Cell Biology
Journal of Cell Biology, 220(2). Rockefeller University Press
Yan et al. demonstrate high-throughput screening of pooled CRISPR libraries for phenotypes detectable by microscopy. Their approach uses photoactivation of cells displaying the phenotype of interest and FACS sorting of marked cells, followed by seque