Zobrazeno 1 - 10
of 40
pro vyhledávání: '"R Leigh Townsend"'
Autor:
Annadora J Bruce-Keller, Sun-Ok Fernandez-Kim, R Leigh Townsend, Claudia Kruger, Richard Carmouche, Susan Newman, J Michael Salbaum, Hans-Rudolf Berthoud
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175577 (2017)
Maternal obesity is known to predispose offspring to metabolic and neurodevelopmental abnormalities. While the mechanisms underlying these phenomena are unclear, high fat diets dramatically alter intestinal microbiota, and gut microbiota can impact p
Externí odkaz:
https://doaj.org/article/d5f721e497504a7aaf3a439def1b7231
Autor:
Harsh Shah, Alyssa Kramer, Caitlyn A. Mullins, Marie Mattern, Ritchel B. Gannaban, R. Leigh Townsend, Shawn R. Campagna, Christopher D. Morrison, Hans-Rudolf Berthoud, Andrew C. Shin
Publikováno v:
Nutrients, Vol 15, Iss 7, p 1713 (2023)
Type 2 diabetes (T2D) is a challenging health concern worldwide. A lifestyle intervention to treat T2D is difficult to adhere, and the effectiveness of approved medications such as metformin, thiazolidinediones (TZDs), and sulfonylureas are suboptima
Externí odkaz:
https://doaj.org/article/5fc50d6c32704af8ba113f8048c94dc5
Autor:
Brandon B. Boland, Michael B. Mumphrey, Zheng Hao, R. Leigh Townsend, Benji Gill, Stephanie Oldham, Sarah Will, Christopher D. Morrison, Sangho Yu, Heike Münzberg, Christopher J. Rhodes, James L. Trevaskis, Hans-Rudolf Berthoud
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 64-72 (2019)
Objective: Understanding the mechanisms underlying the remarkable beneficial effects of gastric bypass surgery is important for the development of non-surgical therapies or less invasive surgeries in the fight against obesity and metabolic disease. A
Externí odkaz:
https://doaj.org/article/f00f453e8c54473090de2a31207bdf75
Autor:
Justine Faramia, Zheng Hao, Michael B. Mumphrey, R. Leigh Townsend, Stéphanie Miard, Anne-Marie Carreau, Mélanie Nadeau, Frédérique Frisch, Elena-Dana Baraboi, Thomas Grenier-Larouche, Christophe Noll, Meng Li, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Stéfane Lebel, Christopher D. Morrison, Heike Münzberg, Denis Richard, André C. Carpentier, André Tchernof, Hans-Rudolf Berthoud, Frédéric Picard
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100248- (2021)
Summary: Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of cardiometabolic health. Here, we report that circulating IGFBP-2 concentrations robustly increase after different bariatric procedures in humans, reaching hig
Externí odkaz:
https://doaj.org/article/317635759b854ab9b3c219568d105c04
Autor:
CHRISTOPHER L. AXELROD, INGEBORG M. LANGOHR, WAGNER S. DANTAS, R. LEIGH TOWNSEND, VANCE L. ALBAUGH, JOHN P. KIRWAN, HANS-RUDOLF BERTHOUD
Publikováno v:
Diabetes. 71
Introduction: Obesity is the primary determinant of nonalcoholic fatty liver disease (NAFLD) . Interventions that decrease body weight, such as bariatric surgery and/or calorie restriction (CR) , may serve as effective therapies for NAFLD. The purpos
Autor:
Robert C. Ross, Yanlin He, R. Leigh Townsend, Philip R. Schauer, Hans-Rudolph Berthoud, Christopher D. Morrison, Vance L. Albaugh
Publikováno v:
The American Surgeon. :000313482311616
Background Obesity contributes significant disease burden worldwide, including diabetes, cardiovascular disease, and cancer. While bariatric surgery is the most effective and durable obesity treatment, the mechanisms underlying its effects remain unk
Autor:
Bita, Zahedi, Eileen J, Daley, Daniel J, Brooks, Michael, Bruce, R Leigh, Townsend, Hans-Rudolf, Berthoud, Mary L, Bouxsein, Elaine W, Yu
Publikováno v:
Bone. 167:116608
Peptide YY (PYY) is an anorexigenic gut hormone that also has anti-osteogenic effects, inhibiting osteoblastic activity and inducing catabolic effects. It has been postulated that increases in PYY after Roux-en-Y gastric bypass (RYGB) contribute to d
Lateral hypothalamic galanin neurons are activated by stress and blunt anxiety-like behavior in mice
Autor:
Joshua Owens-French, Shi-Bin Li, Marie Francois, R. Leigh Townsend, Mischael Daniel, Heather Soulier, Amy Turner, Luis de Lecea, Heike Münzberg, Christopher Morrison, Emily Qualls-Creekmore
Publikováno v:
Behav Brain Res
Despite the prevalence of anxiety disorders, the molecular identity of neural circuits underlying anxiety remains unclear. The lateral hypothalamus (LH) is one brain region implicated in the regulation of anxiety, and our recent data found that chemo
Autor:
Christopher J. Rhodes, R. Leigh Townsend, Sangho Yu, Hans-Rudolf Berthoud, James L. Trevaskis, Michael B. Mumphrey, Stephanie Oldham, Brandon B. Boland, Zheng Hao, Sarah Will, Heike Münzberg, Benji Gill, Christopher D. Morrison
Publikováno v:
Molecular Metabolism, Vol 25, Iss, Pp 64-72 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Understanding the mechanisms underlying the remarkable beneficial effects of gastric bypass surgery is important for the development of non-surgical therapies or less invasive surgeries in the fight against obesity and metabolic disease. Al
Autor:
R. Leigh Townsend, Michael B. Mumphrey, Hans-Rudolf Berthoud, Zheng Hao, Presheet Patkar, Andrew Shin
Publikováno v:
International journal of obesity (2005)
Objectives: Dieting often fails because weight loss triggers strong counter-regulatory biological responses such as increased hunger and hypometabolism that are thought to be critically dependent on the master fuel sensor in the mediobasal hypothalam