Výsledky vyhledávání - "R L Weinshank"

ChemInform Abstract: Design, Synthesis and Evaluation of Substituted Triarylnipecotic Acid Derivatives as GABA Uptake Inhibitors: Identification of a Ligand with Moderate Affinity and Selectivity for the Cloned Human GABA Transporter GAT-3

Autor: Sriram Tyagarajan, Laurence A. Borden, R L Weinshank, K. E. Smith, C. Gluchowski, T. G. M. Dhar, Theresa Branchek

Publikováno v: ChemInform. 25

gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. Molecular biology has revealed the presence of four high-affinity GABA transporters in the brain, GAT-1, GAT-2, GAT-3, and BGT-1, the lat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c740f95eb29cd6e0f25642ad68b801b
https://doi.org/10.1002/chin.199451176

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Molecular cloning and pharmacological characterization of guinea pig 5-HT1B and 5-HT1D receptors

Autor: J M, Zgombick, J A, Bard, S A, Kucharewicz, D A, Urquhart, R L, Weinshank, T A, Branchek

Publikováno v: Neuropharmacology. 36(4-5)

Human 5-HT1B and 5-HT1D receptors have been implicated as molecular targets for the treatment of acute migraine based upon the pharmacological actions and clinical efficacy of sumatriptan, an agonist for human 5-HT1B/1D receptors. The guinea pig has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a3b275bc8a4ee2508f4b4ee64181f9f
https://pubmed.ncbi.nlm.nih.gov/9225276

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Modeling the G-protein-coupled neuropeptide Y Y1 receptor agonist and antagonist binding sites

Autor: J. A. Salon, C. Hou, W. Cui, T A Branchek, Imadul Islam, Yasuchika Yamaguchi, H. Rueger, P. Du, N. Boyle, J. A. Tamm, Y. Shifman, P. J.-J. Vaysse, Daljit S. Dhanoa, Charles Gluchowski, R L Weinshank, Tibur Schmidlin, Mary W. Walker, B. Dowling, N Adham

Publikováno v: Protein engineering. 10(2)

has been discovered (Figure 1b; Rudolf et al., 1994).Neuropeptide Y (NPY) receptors belong to the G-protein- To study the ligand–receptor interactions between the Y1coupled receptor (GPCR) superfamily and mediate several receptor and BIBP3226 Y1 as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d34b339e21b8e945a0709213e726ff
https://pubmed.ncbi.nlm.nih.gov/9089810

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Pharmacological characterizations of recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes coupled to adenylate cyclase inhibition in clonal cell lines: apparent differences in drug intrinsic efficacies between human 5-HT1D subtypes

Autor: J M, Zgombick, L E, Schechter, N, Adham, S A, Kucharewicz, R L, Weinshank, T A, Branchek

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 354(3)

Recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes were stably expressed in NIH-3T3 fibroblasts (1D alpha cell line) and Y-1 adrenocortical tumor cells (1D beta cell line), respectively, for pharmacological evaluations of serotonergic c

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https://pubmed.ncbi.nlm.nih.gov/8878051

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Modeling and mutagenesis of the human alpha 1a-adrenoceptor: orientation and function of transmembrane helix V sidechains

Autor: J M, Wetzel, J A, Salon, J A, Tamm, C, Forray, D, Craig, H, Nakanishi, W, Cui, P J, Vaysse, G, Chiu, R L, Weinshank, P R, Hartig, T A, Branchek, C, Gluchowski

Publikováno v: Receptorschannels. 4(3)

A 3-dimensional model of the seven transmembrane helical segments (TMs) of the human alpha 1a-adrenoceptor was initially built by analogy to the known structure of bacteriorhodopsin. However, the rotational orientation of TM V about its helical axis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18374e29e2fb5f661d44fe3ff9b572e8
https://pubmed.ncbi.nlm.nih.gov/9014240

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Re-evaluation of GABA transport in neuronal and glial cell cultures: correlation of pharmacology and mRNA localization

Autor: L A, Borden, K E, Smith, P J, Vaysse, E L, Gustafson, R L, Weinshank, T A, Branchek

Publikováno v: Receptorschannels. 3(2)

Molecular cloning has revealed the existence of four distinct transporters for the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), termed GAT-1, GAT-2, GAT-3, and BGT-1. To determine which of the cloned transporters are in neurons and whi

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https://pubmed.ncbi.nlm.nih.gov/8581400

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The rat homologue of the bovine alpha 1c-adrenergic receptor shows the pharmacological properties of the classical alpha 1A subtype

Autor: T M, Laz, C, Forray, K E, Smith, J A, Bard, P J, Vaysse, T A, Branchek, R L, Weinshank

Publikováno v: Molecular pharmacology. 46(3)

The cDNA for the rat alpha 1c-adrenergic receptor (AR) has been cloned using a probe derived from the bovine alpha 1c-AR sequence. Clone rB7a has a 2.6-kilobase insert with a 1390-base pair open reading frame and encodes a receptor of 466 amino acids

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https://pubmed.ncbi.nlm.nih.gov/7935320

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Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3

Autor: K. E. Smith, C. Gluchowski, R L Weinshank, Theresa Branchek, Sriram Tyagarajan, T. G. M. Dhar, Laurence A. Borden

Publikováno v: Journal of medicinal chemistry. 37(15)

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https://pubmed.ncbi.nlm.nih.gov/8057281

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The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype

Autor: C, Forray, J A, Bard, J M, Wetzel, G, Chiu, E, Shapiro, R, Tang, H, Lepor, P R, Hartig, R L, Weinshank, T A, Branchek

Publikováno v: Molecular pharmacology. 45(4)

Molecular cloning studies have revealed the existence of three subtypes of alpha 1-adrenergic receptors. However, the link between any individual subtype and its functional role in the body has remained elusive. In an effort to bridge the gap between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc34122e0f6a63b0c1eddaa4754198b8
https://pubmed.ncbi.nlm.nih.gov/8183249

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Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site

Autor: L A, Borden, T G, Dhar, K E, Smith, T A, Branchek, C, Gluchowski, R L, Weinshank

Publikováno v: Receptorschannels. 2(3)

Molecular cloning has revealed the presence of four high-affinity GABA transporters in the brain. The existence of three of these sites, GAT-2, GAT-3, and BGT-1, was unknown prior to their cloning and almost nothing is known of the role they play in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf65e6df8ddb8418aa65dca5ff894971
https://pubmed.ncbi.nlm.nih.gov/7874447

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