Zobrazeno 1 - 10
of 22
pro vyhledávání: '"R L Then"'
Publikováno v:
Parasitology Research. 81:296-301
The new bacteriocidal drug epiroprim (Ro-11-8958) was tested (alone or in combination with dapsone) on its efficacy against Toxoplasma gondii and Pneumocystis carinii in their hosts: laboratory mice and/or nude mice/rats, and was compared to the cura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e64a04d1d10919c86889d0cfe45c00
https://doi.org/10.1007/bf00931533
https://doi.org/10.1007/bf00931533
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:1803-1807
We examined the effect of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone, against Toxoplasma gondii. In vitro, the anti-T. gondii effects of epiroprim and dapsone were observed at nanogram-per-milli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f411b4388edf9b9105568a89d627502d
https://doi.org/10.1128/aac.38.8.1803
https://doi.org/10.1128/aac.38.8.1803
Autor:
G E, Dale, C, Broger, A, D'Arcy, P G, Hartman, R, DeHoogt, S, Jolidon, I, Kompis, A M, Labhardt, H, Langen, H, Locher, M G, Page, D, Stüber, R L, Then, B, Wipf, C, Oefner
Publikováno v:
Journal of molecular biology. 266(1)
A single amino acid substitution, Phe98 to Tyr98, in dihydrofolate reductase (DHFR) is the molecular origin of trimethoprim (TMP) resistance in Staphylococcus aureus. This active site amino acid substitution was found in all S. aureus TMP-resistant c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::768e21e3650ddf473471c9dcf0879738
https://pubmed.ncbi.nlm.nih.gov/9054967
https://pubmed.ncbi.nlm.nih.gov/9054967
Publikováno v:
Advances in experimental medicine and biology. 338
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf1fa7d3cfd92756b0cb97702f74663c
https://pubmed.ncbi.nlm.nih.gov/8304174
https://pubmed.ncbi.nlm.nih.gov/8304174
Publikováno v:
Chemotherapy. 38(2)
Resistant variants of three clinical Pseudomonas aeruginosa isolates were obtained in the presence of aztreonam. The variants exhibited a four- to eightfold increase in the minimal inhibitory concentrations to beta-lactam antibiotics (except imipenem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76d8370ecf38680db231886a118973f1
https://pubmed.ncbi.nlm.nih.gov/1591950
https://pubmed.ncbi.nlm.nih.gov/1591950
Publikováno v:
Antimicrobial Agents and Chemotherapy. 30:684-688
Mutants of Enterobacter cloacae, selected in vitro with ceftriaxone, ceftazidime, carumonam, or aztreonam, fell into several distinct classes. Three mutants highly resistant to nearly all beta-lactam antibiotics were stably derepressed for beta-lacta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aba8975af093ae17c2ff4b7dace1ff5
https://doi.org/10.1128/aac.30.5.684
https://doi.org/10.1128/aac.30.5.684
Autor:
C. Pascual, R. L. Then, I. Kompis, Berry Birdsall, G. C. K. Roberts, A. Kroehn, K. Mueller, James Feeney
Publikováno v:
Journal of Medicinal Chemistry. 27:1672-1676
A consideration of the detailed structural information available from X-ray crystallographic and NMR studies on complexes of dihydrofolate reductase with inhibitors has led to the design of trimethoprim analogues with improved binding properties. Com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80c37f2256d0bc5cd91074a409991230
https://doi.org/10.1021/jm00378a025
https://doi.org/10.1021/jm00378a025
Autor:
Jean-Claude Pechère, Raymond Auckenthaler, I R Vladoïanu, S Suter, F Bellido, P Wacker, R L Then
Publikováno v:
Antimicrobial agents and chemotherapy. 33(7)
A patient with Salmonella muenchen sepsis was unsuccessfully treated with ampicillin. During therapy, four strains that showed stepwise ampicillin resistance and affected other beta-lactams and unrelated antibiotics were isolated sequentially. Resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f844cea2ba85d53ad84a885f0a2a21f4
https://pubmed.ncbi.nlm.nih.gov/2782862
https://pubmed.ncbi.nlm.nih.gov/2782862
Publikováno v:
Journal of medicinal chemistry. 27(12)
A consideration of the detailed structural information available from X-ray crystallographic and NMR studies on complexes of dihydrofolate reductase with inhibitors has led to the design of trimethoprim analogues with improved binding properties. Com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c076c35d2aa647523ebfcf2112384c96
https://pubmed.ncbi.nlm.nih.gov/6438320
https://pubmed.ncbi.nlm.nih.gov/6438320
Autor:
R L, Then
Publikováno v:
Chemotherapy. 30(6)
Against a variety of beta-lactamases tested, mostly of chromosomal origin, Ro 17-2301 (AMA-1080) proved to be more stable than the new cephalosporins and thus resembles aztreonam. Against the beta-lactamases from Klebsiella oxytoca and Pseudomonas vu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::058c0b8cdb27d70176b57322e8c4653e
https://pubmed.ncbi.nlm.nih.gov/6335074
https://pubmed.ncbi.nlm.nih.gov/6335074