Zobrazeno 1 - 10
of 19
pro vyhledávání: '"R L Seither"'
Publikováno v:
Journal of Biological Chemistry. 269:4267-4272
This laboratory previously described an L1210 leukemia cell line (MTXrA) selected for resistance to methotrexate by virtue of impaired transport. In this line, the reduced folate carrier had unchanged affinity for methotrexate, was present at the cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac8b1b4cf71e9ebb39dfc857af0e88b7
https://doi.org/10.1016/s0021-9258(17)41773-x
https://doi.org/10.1016/s0021-9258(17)41773-x
Publikováno v:
Biochemical Pharmacology. 42:1015-1019
Following exposure of L1210 leukemia cells to antifolates, tetrahydrofolate-dependent purine and pyrimidine biosyntheses are blocked despite the presence of the major portion of tetrahydrofolate cofactors. Previous studies from this laboratory demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bbd04d836f34928fb31feaef60c8527
https://doi.org/10.1016/0006-2952(91)90283-b
https://doi.org/10.1016/0006-2952(91)90283-b
Publikováno v:
Journal of Biological Chemistry. 266:5445-5449
Previous studies from this laboratory established that the rapid but partial interconversion of tetrahydrofolate cofactors to dihydrofolate after exposure of L1210 leukemia cells to antifolates cannot be due to direct feedback inhibition of thymidyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e461952471e43b2387810f4f5df2ddb
https://doi.org/10.1016/s0021-9258(19)67615-5
https://doi.org/10.1016/s0021-9258(19)67615-5
Publikováno v:
Journal of Biological Chemistry. 266:4112-4118
An important unresolved issue in antifolate pharmacology is the basis for the observation that the major portion of cellular tetrahydrofolate cofactors is preserved after dihydrofolate reductase activity is abolished by antifolates despite the fact t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2a40bb8fb9fa06d8c643dbf761b7c83
https://doi.org/10.1016/s0021-9258(20)64293-4
https://doi.org/10.1016/s0021-9258(20)64293-4
Publikováno v:
Journal of Biological Chemistry. 265:12149-12155
Serine hydroxymethyltransferase and the trifunctional enzyme C1-tetrahydrofolate synthase have been purified to near homogeneity from L1210 cells. Kinetic constants (Km and kcat) have been determined for both folate and non-folate substrates. The eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53a69893a95c7d2e1d09bb3cf7420e11
https://doi.org/10.1016/s0021-9258(19)38324-3
https://doi.org/10.1016/s0021-9258(19)38324-3
Publikováno v:
Computers & Mathematics with Applications. 20:87-101
Utilizing the network thermodynamic approach, it is possible to simulate large, nonlinear dynamic systems on SPICE2. For this purpose SPICE2 can become a general systems simulator in spite of the fact that it was originally designed for simulating in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7499c04524ba6a1bcdb1e1310a78fc2a
https://doi.org/10.1016/0898-1221(90)90318-e
https://doi.org/10.1016/0898-1221(90)90318-e
Publikováno v:
The Journal of biological chemistry. 269(6)
This laboratory previously described an L1210 leukemia cell line (MTXrA) selected for resistance to methotrexate by virtue of impaired transport. In this line, the reduced folate carrier had unchanged affinity for methotrexate, was present at the cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a46737051e80cf1a6b946469aad90c3
https://pubmed.ncbi.nlm.nih.gov/8307991
https://pubmed.ncbi.nlm.nih.gov/8307991
Publikováno v:
Biochemical pharmacology. 43(12)
Previous studies from this laboratory demonstrated that marked suppression of thymidylate synthase activity is required to slow the rate of interconversion of tetrahydrofolate cofactors to dihydrofolate when dihydrofolate reductase is blocked by an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36018059cab51ae4babe1d3b64ed1471
https://pubmed.ncbi.nlm.nih.gov/1385949
https://pubmed.ncbi.nlm.nih.gov/1385949
Publikováno v:
Biochemical pharmacology. 42(5)
Following exposure of L1210 leukemia cells to antifolates, tetrahydrofolate-dependent purine and pyrimidine biosyntheses are blocked despite the presence of the major portion of tetrahydrofolate cofactors. Previous studies from this laboratory demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::113fac224e0aca26bf21b5162ee31a17
https://pubmed.ncbi.nlm.nih.gov/1831361
https://pubmed.ncbi.nlm.nih.gov/1831361
Publikováno v:
The Journal of biological chemistry. 266(9)
Previous studies from this laboratory established that the rapid but partial interconversion of tetrahydrofolate cofactors to dihydrofolate after exposure of L1210 leukemia cells to antifolates cannot be due to direct feedback inhibition of thymidyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42783d6290c790cf3ff8c87ee246da69
https://pubmed.ncbi.nlm.nih.gov/1825999
https://pubmed.ncbi.nlm.nih.gov/1825999