Zobrazeno 1 - 8
of 8
pro vyhledávání: '"R L Nonay"'
Publikováno v:
Journal of Biological Chemistry. 271:20088-20095
The biological consequences of O6-methylguanine (m6G) in DNA are well recognized. When template m6G is encountered by DNA polymerases, replication is hindered and trans-lesion replication results in the preferential incorporation of dTMP opposite tem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eabf8800cd3478deb644c2ea90f5f581
https://doi.org/10.1074/jbc.271.33.20088
https://doi.org/10.1074/jbc.271.33.20088
Autor:
R L Nonay, Linda J. Reha-Krantz
Publikováno v:
Journal of Biological Chemistry. 269:5635-5643
Polymerases in general share only a few regions of amino acid similarity. One of the most conserved regions, called motif A, has the sequence DXXSLYPSII or a similar sequence in many eukaryotic and viral DNA polymerases and in bacteriophage T4 DNA po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::861513d231591b58625ac341b70f3b44
https://doi.org/10.1016/s0021-9258(17)37508-7
https://doi.org/10.1016/s0021-9258(17)37508-7
Autor:
R L Nonay, Linda J. Reha-Krantz
Publikováno v:
Journal of Biological Chemistry. 268:27100-27108
DNA polymerase exonucleolytic proofreading is important in attaining high fidelity DNA replication. One of the most well characterized proofreading activities is the 3'-->5'-exonuclease activity of bacteriophage T4 DNA polymerase. We have used geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeaed3e5a112b6ab95dc16b6570434d3
https://doi.org/10.1016/s0021-9258(19)74223-9
https://doi.org/10.1016/s0021-9258(19)74223-9
Publikováno v:
Journal of Virology. 67:60-66
Mutations that conferred sensitivity to the pyrophosphate analog phosphonoacetic acid in bacteriophage T4 DNA polymerase were identified. The mutations were loosely clustered in four regions of the gene. As found for herpes simplex virus DNA polymera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5487fc67501920880cc219fd1379ac7
https://doi.org/10.1128/jvi.67.1.60-66.1993
https://doi.org/10.1128/jvi.67.1.60-66.1993
Autor:
S Stocki, Eleanor K. Spicer, Leo D. Goodrich, Linda J. Reha-Krantz, William H. Konigsberg, Eloisa Dimayuga, R L Nonay
Publikováno v:
Proceedings of the National Academy of Sciences. 88:2417-2421
Classical genetic selection was combined with site-directed mutagenesis to study bacteriophage T4 DNA polymerase 3'----5' exonuclease activity. A mutant DNA polymerase with very little (less than or equal to 1%) 3'----5' exonuclease activity was gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1264eb776cad474a968393266944e08
https://doi.org/10.1073/pnas.88.6.2417
https://doi.org/10.1073/pnas.88.6.2417
Publikováno v:
Journal of molecular biology. 254(1)
Many DNA polymerases are multifunctional with the ability to replicate DNA as well as to proofread misincorporated nucleotides. Since polymerase and 3'--> 5' exonuclease activities appear to reside in spatially distinct active centers, there must be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d85ac952b40d71ce1f6a6bd0e58057d
https://pubmed.ncbi.nlm.nih.gov/7473755
https://pubmed.ncbi.nlm.nih.gov/7473755
Autor:
L J, Reha-Krantz, R L, Nonay
Publikováno v:
The Journal of biological chemistry. 269(8)
Polymerases in general share only a few regions of amino acid similarity. One of the most conserved regions, called motif A, has the sequence DXXSLYPSII or a similar sequence in many eukaryotic and viral DNA polymerases and in bacteriophage T4 DNA po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78bd643b5457be51445454709ae242cc
https://pubmed.ncbi.nlm.nih.gov/8119900
https://pubmed.ncbi.nlm.nih.gov/8119900
Autor:
L J, Reha-Krantz, R L, Nonay
Publikováno v:
The Journal of biological chemistry. 268(36)
DNA polymerase exonucleolytic proofreading is important in attaining high fidelity DNA replication. One of the most well characterized proofreading activities is the 3'--5'-exonuclease activity of bacteriophage T4 DNA polymerase. We have used genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::500ea89cbcda77a26459ed5e8bcef4d5
https://pubmed.ncbi.nlm.nih.gov/8262948
https://pubmed.ncbi.nlm.nih.gov/8262948