Výsledky vyhledávání

Chimeric D1/D2 dopamine receptors. Distinct determinants of selective efficacy, potency, and signal transduction

Autor: R L Neve, Kim A. Neve, C A Machida, Laura B. Kozell

Publikováno v: Journal of Biological Chemistry. 269:30299-30306

D1/D2 chimeras were constructed that had D1 dopamine receptor sequence at the amino-terminal end and D2 dopamine receptor sequence at the carboxyl-terminal end. The chimeras with the first four, five and six transmembrane domains of the D1 receptor (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec9fd376f84bb5436de1839cb379cca4
https://doi.org/10.1016/s0021-9258(18)43812-4

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Role of VTA dopamine firing rates and morphology in the regulation of anxiety related behavior in the ClockΔ19 mouse model of mania

Autor: L F Coque, S Mukherjee, J.-L Cao, S M Spencer, M Marvin, E Falcón, M M Sidor, S G Birnbaum, A Pettersen, R L Neve, E A Gordon, A R Ozburn, M S Goldberg, M.-H Han, D C Cooper, C A Mcclung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c561d779e9dfaae601fa57a5197efb5c

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Transient viral-mediated overexpression of alpha-calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell leads to long-lasting functional upregulation of alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors: dopamine type-1 receptor and protein kinase A dependence

Autor: B F, Singer, J A, Loweth, R L, Neve, P, Vezina

Publikováno v: The European journal of neuroscience. 31(7)

Calcium/calmodulin-dependent protein kinase II (CaMKII) activity is necessary for the long-lasting expression of locomotor sensitization and enhanced drug-taking observed in rats previously exposed to psychostimulants. Exposure to these drugs also tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b76e7b53be26b93de0f8c6d1690d6a17
https://pubmed.ncbi.nlm.nih.gov/20345911

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Generation of high-titer defective HSV-1 vectors

Autor: F, Lim, R L, Neve

Publikováno v: Current protocols in neuroscience.

There are two types of replication-deficient herpes simplex virus type 1 (HSV-1) vectors: those in which the foreign DNA of interest is cloned into the viral genome itself, and those that are comprised of a plasmid (amplicon) carrying minimal HSV-1 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8de1bd3a625ea5f40c4f7d1bfbed7fdb
https://pubmed.ncbi.nlm.nih.gov/18428477

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Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens

Autor: A M, Pliakas, R R, Carlson, R L, Neve, C, Konradi, E J, Nestler, W A, Carlezon

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(18)

Drugs of abuse regulate the transcription factor cAMP response element-binding protein (CREB) in striatal regions, including the nucleus accumbens (NAc). To explore how regulation of CREB in the NAc affects behavior, we used herpes simplex virus (HSV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e435a2884bb921b10cc671eeac9f0fd
https://pubmed.ncbi.nlm.nih.gov/11549750

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Herpes simplex virus-mediated gene transfer as a tool for neuropsychiatric research

Autor: W A, Carlezon, E J, Nestler, R L, Neve

Publikováno v: Critical reviews in neurobiology. 14(1)

There is an enormous initiative to establish causal relationships between brain biology (including patterns of gene expression) and behavior. Unfortunately, genetic intervention is not accomplished easily in the brain. One strategy is to engineer and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10379d321be726b50e3869c51b548fb1
https://pubmed.ncbi.nlm.nih.gov/11253955

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Alzheimer's disease: a dysfunction of the amyloid precursor protein(1)

Autor: R L, Neve, D L, McPhie, Y, Chen

Publikováno v: Brain research. 886(1-2)

In this review, we argue that at least one insult that causes Alzheimer's disease (AD) is disruption of the normal function of the amyloid precursor protein (APP). Familial Alzheimer's disease (FAD) mutations in APP cause a disease phenotype that is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19c24de7c6ddd25213adbf8a66457ca8
https://pubmed.ncbi.nlm.nih.gov/11119687

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Genetic analysis of neuronal physiology with defective herpes simplex virus vectors

Autor: R L, Neve, A I, Geller

Publikováno v: Advances in neurology. 79

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bfe5d3194d9d85ef189252b9ce3f4dce
https://pubmed.ncbi.nlm.nih.gov/10514884

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Protein targeting in neurons and endocrine cells

Autor: A E, West, C, Provoda, R L, Neve, K M, Buckley

Publikováno v: Advances in pharmacology (San Diego, Calif.). 42

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9315acc98efb9f7c812e4ade6961326d
https://pubmed.ncbi.nlm.nih.gov/9327890

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Characterization of a recombinant human dopamine transporter in multiple cell lines

Autor: A J, Eshleman, R L, Neve, A, Janowsky, K A, Neve

Publikováno v: The Journal of pharmacology and experimental therapeutics. 274(1)

A 3.5-kilobase cDNA encoding the dopamine transporter was isolated from a human substantia nigra cDNA library. Sequence analysis of the coding region of the transporter identified two nucleotide differences between the cDNA and published human dopami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::72304a547f331447e3a706bb4151b75b
https://pubmed.ncbi.nlm.nih.gov/7616409

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