Zobrazeno 1 - 10
of 15
pro vyhledávání: '"R L McQuinn"'
Autor:
S. F. Chang, R. L. McQuinn, G. V. P. Chamberlain, A. J. Camm, S. Wafa, J. M. Frappell, A. Pisani, A. M. Miller
Publikováno v:
Clinical pharmacology and therapeutics. 48(3)
Healthy human volunteers who intended not to breast feed were placed on a regimen of 100 mg oral flecainide every 12 hours for 5 1/2 days beginning 1 day after parturition. Milk and blood samples were collected during the dosing period and for 2 days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50963843b73c3c8df9d5651d4237c93
https://pubmed.ncbi.nlm.nih.gov/2119270
https://pubmed.ncbi.nlm.nih.gov/2119270
Autor:
C. R. Kehe, Shaw F. Chang, T. M. Welscher, M. J. Jernberg, J. M. Fox, R. L. McQuinn, A. M. Miller
Publikováno v:
Journal of Liquid Chromatography. 8:1903-1913
A simple, selective and sensitive HPLC method has been developed to measure R-831 levels in dogs and humans. It is an internal standard technique with a single step extraction and one wash. Samples are chromatographed on a reversed-phase system with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::647348363dbe16adb6be14f9e5e28863
https://doi.org/10.1080/01483918508074104
https://doi.org/10.1080/01483918508074104
Publikováno v:
Journal of Medicinal Chemistry. 24:1429-1432
In order to investigate the structural requirements for a cycloalkyl moiety in the potent hallucinogen 141phenylcyc1ohexyl)piperidine (PCP, l), a series of structural analogues was synthesized in which the size of the cycloalkyl ring was varied from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1b462e4fce6603c5e6e814e65fdc23
https://doi.org/10.1021/jm00144a011
https://doi.org/10.1021/jm00144a011
Autor:
R L, McQuinn, G J, Quarfoth, J D, Johnson, E H, Banitt, S V, Pathre, S F, Chang, R E, Ober, G J, Conard
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 12(4)
The metabolism of 14C-flecainide acetate, a new antiarrhythmic, was investigated in four healthy human subjects, after a single, 200-mg oral dose. The cumulative recovery of radioactivity ranged from 81 to 90% (mean, 86%) in urine and from 4 to 6% (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b817388ce6ed8081a0c1e2386ade2f8d
https://pubmed.ncbi.nlm.nih.gov/6148206
https://pubmed.ncbi.nlm.nih.gov/6148206
Autor:
D R, Jasinski, H E, Shannon, D B, Vaupel, E J, Cone, M E, Risner, R L, McQuinn, T P, Su, W B, Pickworth
Publikováno v:
Psychopharmacology bulletin. 16(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::968fd485d038b4e1c7350438c7ca8f75
https://pubmed.ncbi.nlm.nih.gov/7454947
https://pubmed.ncbi.nlm.nih.gov/7454947
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 5(4)
Biotransformation of morphine to dihydromorphinone and normorphine was studied in several mammalian species. Free and total dihydromophinone, morphine, and normorphine in the urine were determined, as propionyl derivatives, with a gas-chromatographic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4bf44727e9aebc0ff14f971cf20e89e0
https://pubmed.ncbi.nlm.nih.gov/70327
https://pubmed.ncbi.nlm.nih.gov/70327
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 196(2)
The purpose of this study was to investigate the kinetics of urinary excretion of heroin and its metabolites in human subjects. Heroin and its metabolites were determined with gas-liquid chromatography. Two studies were conducted, each using 10 subje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e947fab852fd529a6899ec699ac17061
https://pubmed.ncbi.nlm.nih.gov/1255475
https://pubmed.ncbi.nlm.nih.gov/1255475
Publikováno v:
Journal of chromatography. 343(1)
A simple, sensitive and selective high-performance liquid chromatographic method has been developed to analyze meta-O-dealkylated flecainide, a major metabolite of flecainide acetate, in human biological fluids. Sample preparation is accomplished thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b403fdc7b3f95f7b4216da72cb212ad
https://pubmed.ncbi.nlm.nih.gov/4066846
https://pubmed.ncbi.nlm.nih.gov/4066846
Publikováno v:
Clinical pharmacology and therapeutics. 43(4)
We studied the effect of renal disease on the pharmacokinetics of flecainide after single intravenous, single oral, and multiple oral doses to patients with severe renal disease (creatinine clearances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12689da0e6ca56aa8125b3acec41fded
https://pubmed.ncbi.nlm.nih.gov/3128417
https://pubmed.ncbi.nlm.nih.gov/3128417
Publikováno v:
Clinical pharmacology and therapeutics. 44(5)
The pharmacokinetics of flecainide were studied in six patients with cirrhosis of the liver and in six healthy subjects after a single 2 mg/kg intravenous dose. Hepatic biotransformation capability before flecainide dosing was assessed by antipyrine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcffd28b2da3d7722c3aef53e796970
https://pubmed.ncbi.nlm.nih.gov/3141098
https://pubmed.ncbi.nlm.nih.gov/3141098