Zobrazeno 1 - 10 of 145 pro vyhledávání: '"R L, Wilder"'
2
Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases
Autor: R L Wilder
Publikováno v: Annals of the Rheumatic Diseases. 61:96ii-99
A substantial and persuasive body of data now exists that supports the view that integrin alpha V beta 3 plays a critical part in activated macrophage dependent inflammation, osteoclast development, migration, and bone resorption, and inflammatory an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2deae5dbb760d229f05aaa6ac0d293b0
https://doi.org/10.1136/ard.61.suppl_2.ii96
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3
Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response
Autor: B Sun, L V Rizzo, S H Sun, C C Chan, B Wiggert, R L Wilder, R R Caspi
Publikováno v: The Journal of Immunology. 159:1004-1011
This study examines whether genetic susceptibility vs resistance to experimental autoimmune uveoretinitis (EAU) in mice is associated with dominant type 1 vs type 2 cytokine response profiles. Mice from six strains were immunized with the uveitogenic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59a4c2eb2960cdb4e66911a98f979f4e
https://doi.org/10.4049/jimmunol.159.2.1004
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4
Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response
Autor: R R Caspi, P B Silver, C C Chan, B Sun, R K Agarwal, J Wells, S Oddo, Y Fujino, F Najafian, R L Wilder
Publikováno v: The Journal of Immunology. 157:2668-2675
This study examines whether genetic susceptibility vs genetic resistance to experimental autoimmune uveoretinitis (EAU) are connected to a predisposition to mount a Th1-dominated (IFN-gamma high, IL-4 low) vs a Th2-dominated (IL-4 high, lFN-gamma low
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46c051f11499ccdfa1a2f8d73d1a524c
https://doi.org/10.4049/jimmunol.157.6.2668
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5
Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-kappa B activity in monocytes and fibroblasts
Autor: R P Donnelly, L J Crofford, S L Freeman, J Buras, E Remmers, R L Wilder, M J Fenton
Publikováno v: The Journal of Immunology. 151:5603-5612
IL-4 inhibits production of certain proinflammatory cytokines, including IL-1 beta, TNF-alpha, and IL-6, by activated monocytes. Although monocytes are a major source of IL-6, other cell types such as fibroblasts and endothelial cells can also expres
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e112f1b2ed61ddb29dbd9597ee46c67e
https://doi.org/10.4049/jimmunol.151.10.5603
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7
The sympathetic nerve--an integrative interface between two supersystems: the brain and the immune system
Autor: I J, Elenkov, R L, Wilder, G P, Chrousos, E S, Vizi
Publikováno v: Pharmacological reviews. 52(4)
The brain and the immune system are the two major adaptive systems of the body. During an immune response the brain and the immune system "talk to each other" and this process is essential for maintaining homeostasis. Two major pathway systems are in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d4cd3b892f6f66302388059230454d0
https://pubmed.ncbi.nlm.nih.gov/11121511
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8
Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis
Autor: M M, Griffiths, J, Wang, B, Joe, S, Dracheva, Y, Kawahito, J S, Shepard, V R, Reese, S, McCall-Vining, A, Hashiramoto, G W, Cannon, E F, Remmers, R L, Wilder
Publikováno v: Arthritis and rheumatism. 43(6)
Collagen-induced arthritis (CIA) is a polygenic model of experimentally induced autoimmunity and chronic joint inflammation. This study maps genetic loci that regulate CIA susceptibility in DA/Bkl (DA) and BN/SsNHsd (BN) rats.Genome scans covering ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::325e6d0691264c1b70f80103c30cf7ff
https://pubmed.ncbi.nlm.nih.gov/10857786
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9
Adrenocorticotropin, glucocorticoid, and androgen secretion in patients with new onset synovitis/rheumatoid arthritis: relations with indices of inflammation
Autor: K S, Kanik, G P, Chrousos, H R, Schumacher, M L, Crane, C H, Yarboro, R L, Wilder
Publikováno v: The Journal of clinical endocrinology and metabolism. 85(4)
To determine whether alterations in adrenocortical function occur early in the development of inflammatory joint disease, we examined patients with new onset synovitis (1 yr) prior to treatment with corticosteroids or other disease-modifying antirheu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e6eee295ca5916b80ba1dffc49534ad0
https://pubmed.ncbi.nlm.nih.gov/10770182
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10
Responses of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis to interleukin-6: a pilot study in fibromyalgia
Autor: D J, Torpy, D A, Papanicolaou, A J, Lotsikas, R L, Wilder, G P, Chrousos, S R, Pillemer
Publikováno v: Arthritis and rheumatism. 43(4)
To determine whether deficient activity of the hypothalamic corticotropin-releasing hormone (CRH) neuron, which stimulates the hypothalamic-pituitary-adrenal (HPA) axis and the central control nuclei of the sympathetic nervous system and inhibits asc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df07511a790fbbaf96e38c4050fe3303
https://pubmed.ncbi.nlm.nih.gov/10765933
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