Zobrazeno 1 - 10
of 47
pro vyhledávání: '"R L, Whiting"'
Publikováno v:
Neurochemical Research. 20:61-68
In the present studies, the pharmacology and regulation of the functional muscarinic receptors on HSDM1C1 cells were probed using phosphoinositide (PI) turnover assays. In addition, the receptor binding of the putative M3-selective radioligand, [3H]4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4417723eeeb5bacfe2e2dea571abb9a5
https://doi.org/10.1007/bf00995154
https://doi.org/10.1007/bf00995154
Autor:
E.H.F. Wong, Richard M. Eglen, Douglas W. Bonhaus, Robin D. Clark, R. L. Whiting, L.G. Johnson, W.L. Smith, C.-H. Lee, E. Leung
Publikováno v:
Neuropharmacology. 33:515-526
The pharmacological properties of the (R) and (S) enantiomers of RS 56532 have been studied in vitro and in vivo. In radioligand binding studies at 5-HT4 receptors in guinea-pig striatum, (S) RS 56532 exhibited a higher affinity than (R) RS 56532 (-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17841ead36a7434ce2ad2043c52aa4c9
https://doi.org/10.1016/0028-3908(94)90083-3
https://doi.org/10.1016/0028-3908(94)90083-3
Autor:
A.M. Domeney, M.E. Kelly, Brenda Costall, Richard M. Eglen, E. H. F. Wong, R. L. Whiting, W.L. Smith, D.M. Tomkins, Robert J. Naylor
Publikováno v:
European Journal of Pharmacology. 234:91-99
The S-isomer of the novel 5-HT3 receptor antagonist RS-42358 ((S)-N-(1-azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1-H- benzo[de]isoquinolin-1-one, RS-42358-197) disinhibited behaviour in the mouse suppressed by the aversive situation of the light/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7dd2b3984e01301e0ec73d2b3a8da96
https://doi.org/10.1016/0014-2999(93)90710-y
https://doi.org/10.1016/0014-2999(93)90710-y
Autor:
Joseph M. Muchowski, A. D. Michel, Richard M. Eglen, L. E. Fisher, R. L. Whiting, Robin D. Clark, D. L. Mcclelland, R. P. Rosenkranz, J. M. Caroon, Edvige Galeazzi
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947cb29109eceb0a3338249b6b2bd256
https://doi.org/10.1002/chin.199608124
https://doi.org/10.1002/chin.199608124
Publikováno v:
Journal of Autonomic Pharmacology. 12:321-333
1. The potency of indole analogues has been studied, in vitro, at 5-hydroxytryptamine4 (5-HT4) receptors mediating contractions of guinea-pig ileum and relaxation of rat oesophagus. These have been compared to other 5-HT receptors in canine saphenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43c4020a2bd91ae8a9b3f9bade2d6698
https://doi.org/10.1111/j.1474-8673.1992.tb00381.x
https://doi.org/10.1111/j.1474-8673.1992.tb00381.x
Publikováno v:
Journal of Autonomic Pharmacology. 12:137-148
1. The effects of acute desensitization of muscarinic receptors mediating contractile responses of the guinea-pig ileal longitudinal muscle were studied in vitro, using similar conditions for both functional and radioligand binding studies. 2. The pA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9ca686f3f903c37b7ea19f0cc5dbf7
https://doi.org/10.1111/j.1474-8673.1992.tb00371.x
https://doi.org/10.1111/j.1474-8673.1992.tb00371.x
Publikováno v:
Neurochemical Research. 16:1167-1174
The effect of centrally and peripherally administered dopamine D1 and D2 specific compounds on core body temperature in mice was investigated. Quinpirole (LY-17155), a D2 agonist, induced a dose-dependent fall in body temperature (2.4-11.6%; p less t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d4cc8f7656a64cb9c45dbbe54f879b
https://doi.org/10.1007/bf00966597
https://doi.org/10.1007/bf00966597
Autor:
R. M. Eglen, R. L. Whiting
Publikováno v:
Journal of Autonomic Pharmacology. 10:233-246
Muscarinic receptors mediate diverse effects on the vasculature. Recently, a consensus has been arrived at with regard to muscarinic receptor classification (Levine & Birdsall, 1989). As a result, it may now be possible to clarify the role of each su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab989711349c1cd4e8e2a4843267e4bd
https://doi.org/10.1111/j.1474-8673.1990.tb00023.x
https://doi.org/10.1111/j.1474-8673.1990.tb00023.x
Publikováno v:
British journal of pharmacology. 149(1)
The current study examined the utility of the recently described prostacyclin (prostanoid IP) receptor antagonist RO1138452 (2-(4-(4-isopropoxybenzyl)-phenylamino) imidazoline) as a tool for classifying prostanoid receptors.pA(2) values were determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f12b16b4fcc5cb013614c3890466fd6
https://pubmed.ncbi.nlm.nih.gov/16880763
https://pubmed.ncbi.nlm.nih.gov/16880763
Autor:
W C, Stanley, B, Li, D W, Bonhaus, L G, Johnson, K, Lee, S, Porter, K, Walker, G, Martinez, R M, Eglen, R L, Whiting, S S, Hegde
Publikováno v:
British journal of pharmacology. 121(8)
1. Inhibitory modulation of sympathetic nerve function may have a favourable impact on the progression of congestive heart failure. Nepicastat is a novel inhibitor of dopamine-beta-hydroxylase, the enzyme which catalyses the conversion of dopamine to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21cbf7d273c2f4c34389284f73b6123b
https://pubmed.ncbi.nlm.nih.gov/9283721
https://pubmed.ncbi.nlm.nih.gov/9283721