Zobrazeno 1 - 10
of 34
pro vyhledávání: '"R L, Warters"'
Publikováno v:
Cell stresschaperones. 6(2)
Heat shock sensitizes cells to ionizing radiation, cells heated in S phase have increased chromosomal aberrations, and both Hsp27 and Hsp70 translocate to the nucleus following heat shock, suggesting that the nucleus is a site of thermal damage. We s
Publikováno v:
Radiation research. 151(3)
The polyamines putrescine (PUT) and spermine (SPM) were examined for their ability to protect human cell DNA against the formation of radiation-induced double-strand breaks (DSBs). As observed previously, under conditions where polyamines were shown
Publikováno v:
Mutation research. 336(1)
The capacity of two radiation-sensitive clones (SX9 and SX10) of the mouse mammary carcinoma cell line SR1 to rejoin radiation-induced DNA double-strand breaks (DSBs) was determined by pulsed-field agarose gel electrophoresis. DSBs were produced with
Publikováno v:
Anti-cancer drug design. 8(5)
The makaluvamines were isolated from a sponge of the genus Zyzzya by following bioactivity against the human colon carcinoma cell line, HCT 116. These compounds have considerable cytotoxic activity. The makaluvamines appear to be acting through inhib
Autor:
R L, Warters, B W, Lyons
Publikováno v:
Radiation research. 134(3)
The induction and closure of double-strand breaks produced by X rays were measured in the replicating DNA of HeLa S3 cells using the techniques of neutral (pH 7.2) filter elution and pulsed-field agarose gel electrophoresis. In whole cell DNA the app
Autor:
R L, Warters, B W, Lyons
Publikováno v:
Radiation research. 130(3)
The influence of chromatin structure on induction of DNA double-strand breaks (DSBs) by X radiation was studied in DNA from CHO cells. Whole cells, nuclei with condensed or relaxed chromatin, and deproteinized DNA in agarose plugs were irradiated and
Autor:
R L, Warters
Publikováno v:
Cancer research. 52(4)
Induction of an apoptotic cell death was studied in a mouse T-cell hybridoma. Apoptosis was induced in these cells following exposure to dexamethasone, X-radiation, 43 degrees C heat shock, A254 light, and hydrogen peroxide. In 5-Gy-exposed cells, a
Autor:
R L, Warters, R, Zagorski
Publikováno v:
Radiation research. 128(2)
The activity of DNA topoisomerase II in the replicating DNA of irradiated Chinese hamster ovary cells was estimated by determining protein-linked DNA double-strand breaks generated in the presence of the DNA intercalative drug 4'-(9-acridinylamino) m
Autor:
R L, Warters, B W, Lyons
Publikováno v:
Radiation research. 124(3)
Chinese hamster ovary cells were irradiated with 250 kVp X rays and analyzed for the presence of DNA double-strand breaks using either polycarbonate filter elution or pulsed-field agarose gel electrophoresis at neutral pH. Reduction in DNA length det
Autor:
R L Warters, K G Hofer
Publikováno v:
Radiation and Environmental Biophysics. 24:161-174
It has been suggested that nascent DNA located at the DNA replication fork may exhibit enhanced sensitivity to radiation damage. To evaluate this hypothesis, Chinese hamster ovary cells (CHO) were labeled with 125I-iododeoxyuridine (125IUdR) either i