Výsledky vyhledávání - "R L, Ullrich"

Radiation-induced instability and its relation to radiation carcinogenesis

Publikováno v: International Journal of Radiation Biology. 74:747-754

PURPOSE: A model that identifies radiation-induced genetic instability as the earliest cellular event in the multi-step sequence leading to radiation-induced cancer was previously proposed. In this paper ongoing experiments are discussed which are de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7d7c6c19fa12e47118f6771e039357
https://doi.org/10.1080/095530098141023

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Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene

Autor: Y, Yu, R, Okayasu, M M, Weil, A, Silver, M, McCarthy, R, Zabriskie, S, Long, R, Cox, R L, Ullrich

Publikováno v: Cancer research. 61(5)

Female BALB/c mice are unusually radiosensitive and more susceptible than C57BL/6 and other tested inbred mice to ionizing radiation (IR)-induced mammary tumors. This breast cancer susceptibility is correlated with elevated susceptibility for mammary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::144a9696d3bfe5882c64046b4412e391
https://pubmed.ncbi.nlm.nih.gov/11280730

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Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells

Autor: T M, Goepfert, M, McCarthy, F S, Kittrell, C, Stephens, R L, Ullrich, B R, Brinkley

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 14(14)

Mammary epithelial cells from p53 null mice have been shown recently to exhibit an increased risk for tumor development. Hormonal stimulation markedly increased tumor development in p53 null mammary cells. Here we demonstrate that mammary tumors aris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c4d5157bffb5b8689859ad9e885727f
https://pubmed.ncbi.nlm.nih.gov/11053243

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Radiation-induced cytogenetic instability in vivo

Autor: R L, Ullrich, C M, Davis

Publikováno v: Radiation research. 152(2)

Radiation-induced cytogenetic instability has been well documented in a number of laboratories, and we have hypothesized that such instability is the initiating event in the process leading to radiation-induced cancer. To date most studies of radiati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80903a98d87f16a82d6daa29e83b471f
https://pubmed.ncbi.nlm.nih.gov/10409326

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Asbestos and DNA double strand breaks

Autor: R, Okayasu, S, Takahashi, S, Yamada, T K, Hei, R L, Ullrich

Publikováno v: Cancer research. 59(2)

A radiosensitive DNA repair-deficient xrs-5 cell line was used to study asbestos cytotoxicity and DNA double strand breaks (DSBs). Although xrs-5 cells did not show any increase in sensitivity to chrysotile fibers in short-term (4-h) treatment when c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3bc336ad46ee6da15e5486bab772d41
https://pubmed.ncbi.nlm.nih.gov/9927035

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Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: the difference is as clear as black and white

Autor: B, Ponnaiya, M N, Cornforth, R L, Ullrich

Publikováno v: Radiation research. 147(2)

Genomic instability has been proposed to be the earliest step in radiation-induced tumorigenesis. It follows from this hypothesis that individuals highly susceptible to induction of tumors by radiation should exhibit enhanced radiation-induced instab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51c9824722690b895b1f6bb1111fec0a
https://pubmed.ncbi.nlm.nih.gov/9008202

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Strain-dependent susceptibility to radiation-induced mammary cancer is a result of differences in epithelial cell sensitivity to transformation

Autor: R L, Ullrich, N D, Bowles, L C, Satterfield, C M, Davis

Publikováno v: Radiation research. 146(3)

Variations in sensitivity to radiation-induced mammary cancer among different strains of mice are well known. However, the reasons for these variations have not been determined. In the present study, the cell dissociation assay was used to determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::646b3a40429f4368b2ccc53babdd9308
https://pubmed.ncbi.nlm.nih.gov/8752316

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Regulation of retinoblastoma gene expression in a mouse mammary tumor model

Autor: E G, Hanania, W W, Au, R L, Ullrich, J, Papaconstantinou

Publikováno v: Cancer gene therapy. 2(4)

We initiated studies to investigate the involvement of the murine retinoblastoma (RB) gene in mammary carcinogenesis using cell lines derived from mammary glands of irradiated mice. We found that the RB mRNA levels as well as the amounts of the nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7aba26ed85970c7ccba432d773e0e364
https://pubmed.ncbi.nlm.nih.gov/8548579

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Latent expression of p53 mutations and radiation-induced mammary cancer

Autor: C S, Selvanayagam, C M, Davis, M N, Cornforth, R L, Ullrich

Publikováno v: Cancer research. 55(15)

EF42 is a clonally derived preneoplastic cell lineage from irradiated mouse mammary tissue, which becomes neoplastic with time in vitro or in vivo. We now report that multiple mutations in p53 occur before the acquisition of the neoplastic phenotype.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b86d2717ab58053ebcef1df6805ba77
https://pubmed.ncbi.nlm.nih.gov/7614466

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