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p38 inhibition and not MK2 inhibition enhances the secretion of chemokines from TNF-α activated rheumatoid arthritis fibroblast-like synoviocytes

Autor: J, Dulos, F P G, Wijnands, J A J, van den Hurk-van Alebeek, M J H, van Vugt, J A C, Rullmann, J-J G, Schot, M W G D M, de Groot, J L, Wagenaars, R, van Ravestein-van Os, R L, Smets, P M, Vink, C L, Hofstra, R L H, Nelissen, H, van Eenennaam

Publikováno v: Clinical and experimental rheumatology. 31(4)

For many years the p38 MAP kinase (MAPK) has been a major anti-inflammatory target for the development of an oral therapy for rheumatoid arthritis (RA). However, disappointing results from Phase II clinical studies suggest that adaptations may occur,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f92a6fea16aca2634734f2c4d693359
https://pubmed.ncbi.nlm.nih.gov/23558031

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