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A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFα

Autor: Annemieke M. H. Boots, P. M. F. Vink, K. Mihara, R. L. Smeets, F. Cavalcanti, H. Kreutzer, John Dulos, M. Rooseboom, C. Almansa, R. L. Nelissen, E. E. M. G. Loomans

Publikováno v: British Journal of Pharmacology. 154:153-164

Background and purpose: The p38 kinase regulates the release of proinflammatory cytokines including tumour-necrosis factor-alpha (TNF alpha) and is regarded as a potential therapeutic target in rheumatoid arthritis (RA). Using the novel p38 inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::821f31a196936574c88a992810075e7f
https://doi.org/10.1038/bjp.2008.53

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Transforming Growth Factor-β2 protects the small intestine during methotrexate treatment in rats possibly by reducing stem cell cycling

Autor: H P Meijer, R L Smeets, L M'Rabet, M Koetsier, J Frerichs, M Hoijer, B van't Land, D Jager

Publikováno v: British Journal of Cancer

During chemo- and radiation therapy, the balance between epithelial cell proliferation, differentiation, and cell death at the villus tip is disrupted by premature death of dividing epithelial cells. This will subsequently lead to the onset of mucosa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f70f08e45b19d53999b4fa0f1b8dccc
https://doi.org/10.1038/sj.bjc.6600342

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A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha

Autor: K, Mihara, C, Almansa, R L, Smeets, E E M G, Loomans, J, Dulos, P M F, Vink, M, Rooseboom, H, Kreutzer, F, Cavalcanti, A M, Boots, R L, Nelissen

Publikováno v: British journal of pharmacology. 154(1)

The p38 kinase regulates the release of proinflammatory cytokines including tumour-necrosis factor-alpha (TNFalpha) and is regarded as a potential therapeutic target in rheumatoid arthritis (RA). Using the novel p38 inhibitor Org 48762-0, we investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::163af1d08d57ef61046d89de9af84ae5
https://pubmed.ncbi.nlm.nih.gov/18297096

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Concerted action of cytosolic Ca2+ and protein kinase C in receptor-mediated phospholipase D activation in Chinese hamster ovary cells expressing the cholecystokinin-A receptor

Autor: R R, Bosch, R L, Smeets, F, Sleutels, A M, Patel, S E, Emst-de Vries, J, Joep, H H, de Pont, P H, Willems

Publikováno v: The Biochemical journal. 337

Receptor-mediated activation of phosphatidylcholine phosphatidohydrolase or phospholipase D (PLD) was studied in Chinese hamster ovary (CHO) cells expressing the cholecystokinin-A (CCK-A) receptor. Cells were labelled with [3H]myristic acid for 24 h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f43d44903a83027a26975c232daa375
https://pubmed.ncbi.nlm.nih.gov/9882623

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Mutational analysis of the potential phosphorylation sites for protein kinase C on the CCK(A) receptor

Autor: R L, Smeets, M A, Fouraux, W, Pouwels, S E, van Emst-de Vries, E, Ronken, J J, De Pont, P H, Willems

Publikováno v: British journal of pharmacology. 124(5)

1. Many G protein-coupled receptors contain potential phosphorylation sites for protein kinase C (PKC), the exact role of which is poorly understood. In the present study, a mutant cholecystokininA (CCK(A)) receptor was generated in which the four co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2a167fd93dcedd03be5048037a18c1c
https://pubmed.ncbi.nlm.nih.gov/9692779

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Protein kinase C-mediated inhibition of transmembrane signalling through CCK(A) and CCK(B) receptors

Autor: R L, Smeets, M A, Fouraux, S E, van Emst-de Vries, J J, De Pont, P H, Willems

Publikováno v: British journal of pharmacology. 123(6)

1. The rat CCK(A) and CCK(B) receptors were stably expressed in Chinese hamster ovary (CHO-09) cells in order to compare modes of signal transduction and effects of protein kinase C (PKC) thereupon. 2. Spectrofluorophotometry of Fura-2-loaded cells r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::916c7eda9791126309596061987948dd
https://pubmed.ncbi.nlm.nih.gov/9559904

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