Výsledky vyhledávání - "R L, Seither"

Increased expression and genomic organization of a folate-binding protein homologous to the human placental isoform in L1210 murine leukemia cell lines with a defective reduced folate carrier

Autor: I D Goldman, E H Westin, K E Brigle, R L Seither

Publikováno v: Journal of Biological Chemistry. 269:4267-4272

This laboratory previously described an L1210 leukemia cell line (MTXrA) selected for resistance to methotrexate by virtue of impaired transport. In this line, the reduced folate carrier had unchanged affinity for methotrexate, was present at the cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac8b1b4cf71e9ebb39dfc857af0e88b7
https://doi.org/10.1016/s0021-9258(17)41773-x

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Compartmentation of intracellular folates

Autor: D F Trent, I. David Goldman, R L Seither

Publikováno v: Biochemical Pharmacology. 42:1015-1019

Following exposure of L1210 leukemia cells to antifolates, tetrahydrofolate-dependent purine and pyrimidine biosyntheses are blocked despite the presence of the major portion of tetrahydrofolate cofactors. Previous studies from this laboratory demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bbd04d836f34928fb31feaef60c8527
https://doi.org/10.1016/0006-2952(91)90283-b

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Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells

Autor: D F Trent, I D Goldman, R L Seither

Publikováno v: Journal of Biological Chemistry. 266:5445-5449

Previous studies from this laboratory established that the rapid but partial interconversion of tetrahydrofolate cofactors to dihydrofolate after exposure of L1210 leukemia cells to antifolates cannot be due to direct feedback inhibition of thymidyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e461952471e43b2387810f4f5df2ddb
https://doi.org/10.1016/s0021-9258(19)67615-5

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Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates

Autor: I D Goldman, T J Rape, D F Trent, D C Mikulecky, R L Seither

Publikováno v: Journal of Biological Chemistry. 266:4112-4118

An important unresolved issue in antifolate pharmacology is the basis for the observation that the major portion of cellular tetrahydrofolate cofactors is preserved after dihydrofolate reductase activity is abolished by antifolates despite the fact t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2a40bb8fb9fa06d8c643dbf761b7c83
https://doi.org/10.1016/s0021-9258(20)64293-4

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Purification and properties of serine hydroxymethyltransferase and C1-tetrahydrofolate synthase from L1210 cells

Autor: I D Goldman, W B Strong, Verne Schirch, R L Seither, S J Tendler

Publikováno v: Journal of Biological Chemistry. 265:12149-12155

Serine hydroxymethyltransferase and the trifunctional enzyme C1-tetrahydrofolate synthase have been purified to near homogeneity from L1210 cells. Kinetic constants (Km and kcat) have been determined for both folate and non-folate substrates. The eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53a69893a95c7d2e1d09bb3cf7420e11
https://doi.org/10.1016/s0021-9258(19)38324-3

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SPICE2 network thermodynamic simulation of antifolate effects on purine and pyrimidine biosynthesis: Exploring the role of tetrahydrofolate cofactor depletion versus dihydrofolate feedback inhibition

Autor: I D Goldman, R L Seither, D. Hearne, D C Mikulecky, D F Trent

Publikováno v: Computers & Mathematics with Applications. 20:87-101

Utilizing the network thermodynamic approach, it is possible to simulate large, nonlinear dynamic systems on SPICE2. For this purpose SPICE2 can become a general systems simulator in spite of the fact that it was originally designed for simulating in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7499c04524ba6a1bcdb1e1310a78fc2a
https://doi.org/10.1016/0898-1221(90)90318-e

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Increased expression and genomic organization of a folate-binding protein homologous to the human placental isoform in L1210 murine leukemia cell lines with a defective reduced folate carrier

Autor: K E, Brigle, R L, Seither, E H, Westin, I D, Goldman

Publikováno v: The Journal of biological chemistry. 269(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a46737051e80cf1a6b946469aad90c3
https://pubmed.ncbi.nlm.nih.gov/8307991

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Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate synthase by fluorodeoxyuridine in L1210 leukemia cells

Autor: I. David Goldman, R L Seither, Tracy J. Rape

Publikováno v: Biochemical pharmacology. 43(12)

Previous studies from this laboratory demonstrated that marked suppression of thymidylate synthase activity is required to slow the rate of interconversion of tetrahydrofolate cofactors to dihydrofolate when dihydrofolate reductase is blocked by an a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36018059cab51ae4babe1d3b64ed1471
https://pubmed.ncbi.nlm.nih.gov/1385949

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