The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs

Autor: Paul Roepman, W. W. J. de Leng, Egbert F. Smit, L.R. Hoes, D.L. van der Velden, Derk Jan A. de Groot, H. van der Wijngaart, Niven Mehra, Alwin D. R. Huitema, C.M.L. van Herpen, Ann Hoeben, A.J. de Langen, J.M. van Berge Henegouwen, Ellen Kapiteijn, Mariette Labots, R. L. Schilsky, Stefan Sleijfer, Lot A. Devriese, Bastiaan Nuijen, Hans Gelderblom, Henk M.W. Verheul, Myriam Chalabi, Emile E. Voest, M.J.A. de Jonge, Edwin Cuppen, Petra M. Nederlof, E. van Werkhoven

Publikováno v: Nature, 574(7776), 127-131. Nature Publishing Group
van der Velden, D L, Hoes, L R, van der Wijngaart, H, van Berge Henegouwen, J M, van Werkhoven, E, Roepman, P, Schilsky, R L, de Leng, W W J, Huitema, A D R, Nuijen, B, Nederlof, P M, van Herpen, C M L, de Groot, D J A, Devriese, L A, Hoeben, A, de Jonge, M J A, Chalabi, M, Smit, E F, de Langen, A J, Mehra, N, Labots, M, Kapiteijn, E, Sleijfer, S, Cuppen, E, Verheul, H M W, Gelderblom, H & Voest, E E 2019, ' The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs ', Nature, vol. 574, no. 7776, pp. 127-131 . https://doi.org/10.1038/s41586-019-1600-x
Nature, 574(7776), 127. Nature Publishing Group
Nature, 574, 7776, pp. 127
Nature, 574(7776), 127-+. Nature Publishing Group
Nature, 574, 127-131. Nature Publishing Group
Nature, 574(7776), 127
Nature, 574, 127

The large-scale genetic profiling of tumours can identify potentially actionable molecular variants for which approved anticancer drugs are available1–3. However, when patients with such variants are treated with drugs outside of their approved lab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd35cdecf0a7ceec5dc3112f6b0b1009
https://doi.org/10.1038/s41586-019-1600-x

Phase I study to evaluate multiple regimens of intravenous 5-fluorouracil administered in combination with weekly gemcitabine in patients with advanced solid tumors: a potential broadly active regimen for advanced solid tumor malignancies

Autor: S, Mani, N J, Vogelzang, D, Bertucci, W M, Stadler, R L, Schilsky, M J, Ratain

Publikováno v: Cancer. 92(6)

The purpose of this study was to determine the maximum tolerated dose and toxicity profile of gemcitabine given on a weekly schedule with continuous infusion 5-fluorouracil.Eligible patients with advanced solid tumors received escalating doses of gem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99a9619933ce99f6314d2e1bc9df92de
https://pubmed.ncbi.nlm.nih.gov/11745236

Antineoplastic drugs administered during pregnancy

Autor: S F, Williams, R L, Schilsky

Publikováno v: Seminars in oncology. 27(6)

Cancer is the second leading cause of death in women during their reproductive years. Thus, antineoplastic drugs may be administered to pregnant women. The effects these agents have on the developing fetus depend on the type of agent and the timing o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7a9dffaf308f47a840245dcd5e0142e
https://pubmed.ncbi.nlm.nih.gov/11130468

Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer

Autor: R L, Schilsky, M E, Dolan, D, Bertucci, R B, Ewesuedo, N J, Vogelzang, S, Mani, L R, Wilson, M J, Ratain

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(8)

O6-benzylguanine (BG) is a potent inactivator of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT) that enhances sensitivity to nitrosoureas in tumor cell lines and tumor-bearing animals. The major objectives of this study were to def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f817a74e7e2e52ec00f8accf22150fd9
https://pubmed.ncbi.nlm.nih.gov/10955771

Colorectal Cancer

Autor: R. L. Schilsky

Publikováno v: Oncologic Therapies ISBN: 9783540781080

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d740c51b5e36f3987f2498c8015f2f6
https://doi.org/10.1007/978-3-642-97988-0_28