Zobrazeno 1 - 9 of 9 pro vyhledávání: '"R L, Redner"'
1
Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha
Autor: E M, Rego, D, Ruggero, C, Tribioli, G, Cattoretti, S, Kogan, R L, Redner, P P, Pandolfi
Recurrent chromosomal translocations involving the RAR alpha locus on chromosome 17 are the hallmark of acute promyelocytic leukemia (APL). The RAR alpha gene fuses to variable partners (PML, PLZF, NPM, NuMA and STAT5B: X genes) leading to the expres
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0e9a4dd58aeb7b0d74bf3f0783f16066
http://hdl.handle.net/2318/61364
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2
The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties
Autor: R L, Redner, J D, Chen, E A, Rush, H, Li, S L, Pollock
Publikováno v: Blood. 95(8)
The t(5;17) variant of acute promyelocytic leukemia (APL) fuses the genes for nucleophosmin (NPM) and the retinoic acid receptor alpha (RARalpha). Two NPM-RAR molecules are expressed as a result of alternative RNA splicing. Both contain RARalpha sequ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbb3ab116ca086d7d571f2a0acff9afc
https://pubmed.ncbi.nlm.nih.gov/10753851
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4
Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes
Autor: C, Du, R L, Redner, M P, Cooke, C, Lavau
Publikováno v: Blood. 94(2)
Retinoic acid receptor alpha (RARalpha) is the target of several chromosomal translocations associated with acute promyelocytic leukemias (APLs). These rearrangements fuse RARalpha to different partner genes creating the chimeric proteins: PML-RARalp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2e8c9b1116a03208f80163355f13ac7
https://pubmed.ncbi.nlm.nih.gov/10397747
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5
Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells
Autor: J, Wang, Y, Saunthararajah, R L, Redner, J M, Liu
Publikováno v: Cancer research. 59(12)
The (8;21) translocation, found in 12% of acute myeloid leukemia (AML), creates the chimeric fusion product, AML1-ETO. Previously, we demonstrated that the ETO moiety recruits a transcription repression complex that includes the histone deacetylase (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa4d16d5935a3fa7eb69e7c53b7e774c
https://pubmed.ncbi.nlm.nih.gov/10383127
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6
A non-classical translocation involving 17q12 (retinoic acid receptor alpha) in acute promyelocytic leukemia (APML) with atypical features
Autor: S J, Corey, J, Locker, D R, Oliveri, S, Shekhter-Levin, R L, Redner, L, Penchansky, S M, Gollin
Publikováno v: Leukemia. 8(8)
Acute promyelocytic leukemia (APML) almost always involves a chromosomal translocation t(15:17) that results in the fusion of the retinoic acid receptor alpha (RAR alpha) gene with a transcription factor gene called PML. Several cases of APML with t(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd484a1f57944a380ddb74ac57b3bf50
https://pubmed.ncbi.nlm.nih.gov/8057672
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7
Variable pattern of jun and fos gene expression in different hematopoietic cell lines during interleukin 3-induced entry into the cell cycle
Autor: R L, Redner, A W, Lee, G A, Osawa, A W, Nienhuis
Publikováno v: Oncogene. 7(1)
Jun (c-jun, jun-B and jun-D) and fos (c-fos, fos-B and fra) proteins dimerize to form the family of AP-1 transcriptional activators. If each dimer exhibits unique transactivating properties, then any phenotypic change should show a characteristic pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d476ecfc55e724d9e5a171cdfbe07b7b
https://pubmed.ncbi.nlm.nih.gov/1371337
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8
An oligomer Complementary to c-myc mRNA Inhibits Proliferation of HL-60 Promyelocytic Cells and Induces Differentiation
Autor: J T, Holt, R L, Redner, A W, Nienhuis
Publikováno v: Molecular and Cellular Biology. 8:963-973
To study the role of a nuclear proto-oncogene in the regulation of cell growth and differentiation, we inhibited HL-60 c-myc expression with a complementary antisense oligomer. This oligomer was stable in culture and entered cells, forming an intrace
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f386aa60d6693790b75b0bd549b8bf
https://doi.org/10.1128/mcb.8.2.963-973.1988
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9
An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation
Autor: J T Holt, R L Redner, Arthur W. Nienhuis
Publikováno v: Molecular and Cellular Biology. 8:963-973
To study the role of a nuclear proto-oncogene in the regulation of cell growth and differentiation, we inhibited HL-60 c-myc expression with a complementary antisense oligomer. This oligomer was stable in culture and entered cells, forming an intrace
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc7e5b69b26a254e8b62afd60199566b
https://doi.org/10.1128/mcb.8.2.963
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