Zobrazeno 1 - 8
of 8
pro vyhledávání: '"R L, Rasmusson"'
Publikováno v:
Die Pharmazie. 63(6)
As the major component of I(to) (slow), Kv1.4 channel plays an important role in repolarization of cardiac myocytes. C-type inactivation is one of Kv1.4 inactivation and can be affected by open channel blockers. We used the two-electrode voltage clam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd891858ec6f3f0f76a80f64f2c57b49
https://pubmed.ncbi.nlm.nih.gov/18604993
https://pubmed.ncbi.nlm.nih.gov/18604993
Publikováno v:
AIP Conference Proceedings.
We applied bifurcation analysis to the Luo-Rudy model of the guinea pig cardiac ventricular cell to investigate the behavior of repolarization in response to a simulated form of inherited arrhythmia, long QT syndrome. In this paper, we simulate patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1002d2a1d6e6c04bc1321c00c9aa12b6
https://doi.org/10.1063/1.1302382
https://doi.org/10.1063/1.1302382
Publikováno v:
The Canadian journal of cardiology. 14(2)
The nature of open state block was characterized in isolated canine cardiac sarcoplasmic reticulum (SR) potassium channel incorporated into planar lipid bilayers. 4-Aminopyridine (4-AP) blocked the open conductance state of the potassium channels in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df6d8bf62b3a8ed33eb6940e74513b6c
https://pubmed.ncbi.nlm.nih.gov/9520865
https://pubmed.ncbi.nlm.nih.gov/9520865
Autor:
S, Liu, R L, Rasmusson
Publikováno v:
The Canadian journal of cardiology. 14(1)
Inactivation is a widespread property of voltage-gated ion channels. Recent molecular biological advances in the potassium channel field have elucidated two mechanistically distinct types of inactivation, N-type and C-type. Both of these mechanisms a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3150a1a3ac13edc93ee20dc4b1e48f3
https://pubmed.ncbi.nlm.nih.gov/9487282
https://pubmed.ncbi.nlm.nih.gov/9487282
Publikováno v:
Advances in experimental medicine and biology. 430
A recently discovered class of ancillary subunits has been shown to modify the inactivation properties of alpha-subunits belonging to the Kv1 family of potassium channels. One of these subunits, Kv beta 1.2, modifies intrinsic alpha-subunit C-type in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::766c45533d9004f04eb2d0aad89f2530
https://pubmed.ncbi.nlm.nih.gov/9330716
https://pubmed.ncbi.nlm.nih.gov/9330716
Autor:
R L, Rasmusson, Y, Zhang, D L, Campbell, M B, Comer, R C, Castellino, S, Liu, M J, Morales, H C, Strauss
Publikováno v:
Advances in experimental medicine and biology. 382
We studied the blocking effects of 4-aminopyridine (4-AP) on a Kv1.4 K+ channel. A permanently charged 4-AP derivative only produced block when applied intracellularly. 4-AP block accumulated from pulse to pulse indicating trapping of 4-AP in deactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62bc3b313237734430c99f08fed0f497
https://pubmed.ncbi.nlm.nih.gov/8540388
https://pubmed.ncbi.nlm.nih.gov/8540388
Autor:
R L, Rasmusson, D L, Campbell
Publikováno v:
Advances in experimental medicine and biology. 311
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7872557cde603e3ee61b37ccf186ba7
https://pubmed.ncbi.nlm.nih.gov/1529769
https://pubmed.ncbi.nlm.nih.gov/1529769
Publikováno v:
Advances in experimental medicine and biology. 311
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b80f28b3ac5f62eea2f055c7a79123b6
https://pubmed.ncbi.nlm.nih.gov/1529768
https://pubmed.ncbi.nlm.nih.gov/1529768