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Cytogenetic follow-up studies of recipients of T-cell depleted allogeneic bone marrow

Autor: Sylvia D. Lawler, Helen Harris, A. Barrett, R. L. Powles, John L. Millar

Publikováno v: British Journal of Haematology. 65:143-150

Summary. Serial cytogenetic studies of bone marrow and blood cells were made in leukaemic patients who had received an allogeneic bone marrow graft from a donor of unlike sex. The donor marrow was treated with the monoclonal antibody Campath-1 before

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b769593d47115d16d49dd66de75094
https://doi.org/10.1111/j.1365-2141.1987.00137.x-i1

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Long-term outcome of autologous stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma

Autor: Jacqui Oates, A C Wotherspoon, T. Arkenau, Bhawna Sirohi, A. R. Norman, R. L. Powles, Alan Horwich, Felicity Murphy, David Cunningham

Publikováno v: Annals of Oncology. 19:1312-1319

The purpose of this study was to assess prognostic factors and outcome of patients with relapsed/refractory Hodgkin's lymphoma (HL) who received high-dose chemotherapy and autologous stem-cell transplant (ASCT).Data on 195 patients who received ASCT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427276cebba718c156f0bcf46d947290
https://doi.org/10.1093/annonc/mdn052

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An open, randomized, controlled, phase II, single centre, two-period cross-over study to compare the quality of life and toxicity experienced on PEG interferon with interferon-α2b in patients with multiple myeloma maintained on a steady dose of interferon-α2b

Autor: D Lawrence, Jennifer Treleaven, R. L. Powles, S Kulkarni, Gareth J. Morgan, C Horton, Bhawna Sirohi, A Leary, Claudius Rudin

Publikováno v: Annals of Oncology. 18:1388-1394

Purpose: To compare the effects of pegylated interferon-alpha 2b (P-IFN) and interferon-alpha 2b (IFN) on quality of life (QoQ and toxicity in patients with multiple myeloma maintained on a steady dose of IFN. Patients and methods: Consenting, eligib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e22efe2f3b92d29789c75c62be2937
https://doi.org/10.1093/annonc/mdm180

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Immunotherapy for Acute Myelogenous Leukemia

Autor: G H Fairley, T. A. Lister, T McElwain, P. Alexander, D Crowther, R L Powles

One hundred and seven untreated patients with acute myelogenous leukemia (AML) were admitted to St. Bartholomew's Hospital between the 10th October 1970 and the 31st January 1973. Before receiving drugs to induce remission they were allocated alterna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1ddd8ec102ae7923c2547e5ffcb0826
https://doi.org/10.1159/000397596

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Use of physiological doses of human growth hormone in haematological patients receiving intensive chemotherapy promotes haematopoietic recovery: a double-blind randomized, placebo-controlled study

Autor: R. L. Powles, Gary Cook, Samar Kulkarni, J. Wass, D. Rolfe, Jennifer Treleaven, Clive Horton, Radovan Saso, Georgia Morgan, Catriona Shaw, Bhawna Sirohi

Publikováno v: Bone Marrow Transplantation. 39:115-120

In vivo and in vitro studies suggest human growth hormone (hGH) receptors on bone marrow stem cells may be biologically active and could be exploited to promote haemopoetic recovery after intensive chemotherapy. Patients with haematological malignanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf458f8a579b09492e3df991f0173f3
https://doi.org/10.1038/sj.bmt.1705545

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Bone marrow transplantation—The Marsden experience

Autor: A. Zuiable, Sam Milliken, G Forgeson, John L. Millar, A. Lakhani, Jennifer Treleaven, A Nandi, Martin Gore, R. L. Powles, Helenglass G

Publikováno v: Hematological Oncology. 5:245-254

Allogeneic bone marrow transplantation (BMT) was first successful at the Royal Marsden Hospital in 1973 and although the programme was initially centred around treating aplastic anaemia, we soon applied the technique to acute leukaemia. Since then we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a709924417096c22a1da71e3813f8b
https://doi.org/10.1002/hon.2900050403

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A study to determine the safety profile and maximum tolerated dose of micafungin (FK463) in patients undergoing haematopoietic stem cell transplantation

Autor: R. L. Powles, Jennifer Byrne, Rajesh Chopra, S Koblinger, Bhawna Sirohi, H. G. Prentice, Michael N. Potter, Nigel H. Russell

Publikováno v: Bone Marrow Transplantation. 38:47-51

This open-label, dose-escalation study assessed the maximum tolerated dose (MTD) of the new antifungal micafungin in patients undergoing haematopoietic stem cell transplantation (HSCT). Participants received 3, 4, 6 or 8 mg/kg/day micafungin intraven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfbdc0b60433ea87ee236bdbb5abd3a
https://doi.org/10.1038/sj.bmt.1705398

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Topical issues in unrelated donor haematopoietic stem cell transplants: a report from a workshop convened by the Anthony Nolan Trust in London – 2005

Autor: Rafael F. Duarte, D Samson, R L Powles, D Marks, D Pamphilon, J. A. Madrigal, John M. Goldman, J F Apperley, G J Mufti, J Cornish, Bronwen E. Shaw, C Craddock

Publikováno v: Bone Marrow Transplantation. 37:901-908

Over more than three decades, The Anthony Nolan Trust (ANT) has provided an unrelated donor (UD) for over 4000 children and adults lacking a suitable family member donor, and has remained at the forefront of developments in haematopoietic stem cell t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::431313e60f76822c632cc57fad35336d
https://doi.org/10.1038/sj.bmt.1705365

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An elective single autograft with high-dose melphalan: single-center study of 451 patients

Autor: Jennifer Treleaven, Claudius Rudin, R. L. Powles, Samar Kulkarni, Jayesh Mehta, Radovan Saso, Bhawna Sirohi, Clive Horton, Seema Singhal

Publikováno v: Bone Marrow Transplantation. 36:19-24

In all, 451 myeloma patients, 51% previously untreated, underwent elective single autotransplantation after 200 mg/m(2) melphalan between 1985 and 2001 at the Royal Marsden Hospital. The therapy sequence was: Induction (vincristine, doxorubicin, meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78205a68e160c5adbc43cae565827ad
https://doi.org/10.1038/sj.bmt.1705000

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