Zobrazeno 1 - 10 of 13 pro vyhledávání: '"R L, Panek"'
1
In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase
Autor: R L, Panek, G H, Lu, T K, Dahring, B L, Batley, C, Connolly, J M, Hamby, K J, Brown
Publikováno v: The Journal of pharmacology and experimental therapeutics. 286(1)
Through direct synthetic efforts, we discovered a small molecule that is a nanomolar inhibitor of the human fibroblast growth factor-1 receptor (FGFR) tyrosine kinase. PD 166866, a member of a new structural class of tyrosine kinase inhibitors, the 6
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c432035338516758306f4fe9411287d1
https://pubmed.ncbi.nlm.nih.gov/9655904
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2
In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor
Autor: R L, Panek, G H, Lu, S R, Klutchko, B L, Batley, T K, Dahring, J M, Hamby, H, Hallak, A M, Doherty, J A, Keiser
Publikováno v: The Journal of pharmacology and experimental therapeutics. 283(3)
PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, the 6-aryl-pyrido[2,3-d]pyrimidines, was synthesized as the most potent and soluble analog of a series of small molecules originally identified by screening a compound li
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26da8706eb44162e5844c858e03851b4
https://pubmed.ncbi.nlm.nih.gov/9400019
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3
Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor
Autor: T K, Dahring, G H, Lu, J M, Hamby, B L, Batley, A J, Kraker, R L, Panek
Publikováno v: The Journal of pharmacology and experimental therapeutics. 281(3)
PD 089828, a novel protein tyrosine kinase inhibitor of a new structural class, the 6-aryl-pyrido-[2,3-d]pyrimidines, was identified by screening a compound library with assays that measured protein tyrosine kinase activity. PD 089828 was found to in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09bf6684f7b707cc339c285c1560e2aa
https://pubmed.ncbi.nlm.nih.gov/9190882
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4
Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists
Autor: J J, Edmunds, S, Klutchko, J M, Hamby, A M, Bunker, C J, Connolly, R T, Winters, J, Quin, I, Sircar, J C, Hodges, R L, Panek
Publikováno v: Journal of medicinal chemistry. 38(19)
A series of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins have been prepared and evaluated as in vitro and in vivo angiotensin II (Ang II) antagonists. Variation of substituents on the hydantoin ring leads to potent and selective Ang II a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b8a82a9c4972cc0534ad577f7fac51a5
https://pubmed.ncbi.nlm.nih.gov/7562906
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5
Functional studies but not receptor binding can distinguish surmountable from insurmountable AT1 antagonism
Autor: R L, Panek, G H, Lu, R W, Overhiser, T C, Major, J C, Hodges, D G, Taylor
Publikováno v: The Journal of pharmacology and experimental therapeutics. 273(2)
Our study demonstrated that inhibition of angiotensin II- (Ang II) mediated contractions of rabbit aorta by structurally diverse nonpeptide AT1 antagonists could distinguish surmountable from insurmountable AT1 antagonism. CI-996, L158809, EXP 3174 a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c9672a36f962a920f26f17c2d59b615
https://pubmed.ncbi.nlm.nih.gov/7752078
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6
Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist
Autor: J A, Keiser, M J, Ryan, R L, Panek, J C, Hodges, I, Sircar
Publikováno v: The Journal of pharmacology and experimental therapeutics. 272(3)
CI-996, a novel potent angiotensin II (Ang II) type 1 (AT1) receptor antagonist was characterized in a number of in vitro and in vivo assays. In addition, CI-996 was compared with several reported AT1 receptor antagonists including losartan, SKF 1085
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22a668a933b6e50c618266f51dcf1040
https://pubmed.ncbi.nlm.nih.gov/7891350
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8
Effects of quinapril, a new angiotensin-converting enzyme inhibitor, on vasoconstrictor activity in the isolated, perfused mesenteric vasculature of hypertensive rats
Autor: T C, Major, R W, Overhiser, D G, Taylor, R L, Panek
Publikováno v: The Journal of pharmacology and experimental therapeutics. 265(1)
Previously, we had reported that 7-day administration of the angiotensin-converting enzyme inhibitor quinapril markedly reduced electrically evoked pressor responses in the isolated, perfused mesenteric vascular bed of the spontaneously hypertensive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::807c2fae5c2167726d9be2fd2b48f03c
https://pubmed.ncbi.nlm.nih.gov/8474005
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9
Evidence for a functional tissue renin-angiotensin system in the rat mesenteric vasculature and its involvement in regulating blood pressure
Autor: R E, Weishaar, R L, Panek, T C, Major, J, Simmerman, S T, Rapundalo, D G, Taylor
Publikováno v: The Journal of pharmacology and experimental therapeutics. 256(2)
Electrical stimulation of the isolated rat mesenteric vascular bed resulted in a frequency-dependent pressor response, which could be potentiated by increasing concentrations of renin substrate (synthetic tetradecapeptide). This potentiating effect a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90fdb95d90b246dc5818cef341b06b09
https://pubmed.ncbi.nlm.nih.gov/1847201
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10
Monocyclic endothelins: examination of the importance of the individual disulfide rings
Autor: W L, Cody, A M, Doherty, X Q, He, S T, Rapundalo, G P, Hingorani, R L, Panek, T C, Major
Publikováno v: Journal of cardiovascular pharmacology. 17
Monocyclic fragment analogues of endothelin-1 (ET-1) were prepared by standard solid-phase peptide synthetic methods. The analogues were designed to determine the importance of the unique bicyclic structure of the endothelins, vasoactive intestinal c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::939b72c112501956b56de66121cc4fd6
https://pubmed.ncbi.nlm.nih.gov/1725434
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