Zobrazeno 1 - 10
of 38
pro vyhledávání: '"R L, Jirtle"'
Autor:
R, Das Chakraborty, D, Chakraborty, A J, Bernal, K, Schoch, T D, Howard, E H, Ip, S R, Hooper, M S, Keshavan, R L, Jirtle, V, Shashi
Publikováno v:
Translational Psychiatry
Chromosome 22q11.2 deletion syndrome (22q11DS) is the most common microdeletion syndrome in humans. It is typified by highly variable symptoms, which might be explained by epigenetic regulation of genes in the interval. Using computational algorithms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee87ca37c38325222ec189bd7244329c
https://pubmed.ncbi.nlm.nih.gov/22832905
https://pubmed.ncbi.nlm.nih.gov/22832905
Autor:
A. F. Purchio, Wilfried Bursch, Bettina Grasl-Kraupp, F. Oberhammer, Roland Sedivy, Rolf Schulte-Hermann, R. L. Jirtle, M. Askari
Publikováno v:
British Journal of Cancer
Cell death by apoptosis is a major determinant of growth of normal tissues and tumours. The present study aimed to elucidate signal factors involved in its regulation. Epithelial cells in control liver, during regression of cyproterone acetate induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f374a9224722dab068c999b7dd48c059
http://europepmc.org/articles/PMC1968248
http://europepmc.org/articles/PMC1968248
Publikováno v:
Cytogenetic and genome research. 113(1-4)
The epigenetic marks on the IGF2R gene that encodes a receptor responsible for IGF-II degradation consist of differentially methylated DNA in association with multiple modifications on the associated histones. We review these epigenetic marks across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7bb911973168312dca618124213bb865
https://pubmed.ncbi.nlm.nih.gov/16575181
https://pubmed.ncbi.nlm.nih.gov/16575181
Publikováno v:
Cancer. 86(9)
Plasma transforming growth factor-beta1 (TGFbeta1) levels are increased in many malignancies at the time of diagnosis, including all forms of lung carcinoma. Therefore, the potential use of TGFbeta1 as a plasma marker to predict the long term outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e46928a2529fe4ebb26156af0c89c7b
https://pubmed.ncbi.nlm.nih.gov/10547543
https://pubmed.ncbi.nlm.nih.gov/10547543
Publikováno v:
Cancer research. 59(17)
The M6P/IGF2R gene, encoding the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor (IGF2R), is frequently inactivated during carcinogenesis. M6P/IGF2R is postulated to be a tumor suppressor gene due to its ability to bind and degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fdef69d24e7e976741b5dabb67618d79
https://pubmed.ncbi.nlm.nih.gov/10485478
https://pubmed.ncbi.nlm.nih.gov/10485478
Autor:
G R, Hankins, A T, De Souza, R C, Bentley, M R, Patel, J R, Marks, J D, Iglehart, R L, Jirtle
Publikováno v:
Oncogene. 12(9)
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2r) functions in the activation of TGFbeta, a potent growth inhibitor for most cell types, the degradation of the mitogen, IGF2, and the intracellular trafficking of lysosomal enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5baa694fc44642f4aa6b14c65bcc6e36
https://pubmed.ncbi.nlm.nih.gov/8649861
https://pubmed.ncbi.nlm.nih.gov/8649861
Publikováno v:
Carcinogenesis. 17(1)
Phenobarbital (PB) is a potent tumor promoter in rodent liver. In this study we investigated whether PB selectively promotes a population of initiated cells with reduced levels of transforming growth factor-beta (TGF beta) receptors types I, II and I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3a9e517a6948570c06266005c8e8fd3
https://pubmed.ncbi.nlm.nih.gov/8565130
https://pubmed.ncbi.nlm.nih.gov/8565130
Publikováno v:
Oncogene. 10(9)
The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGFIIr) is required for the activation of transforming growth factor beta, and previously we have found its expression to be significantly reduced in both rat and human hepatocellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ea31d637b94d1fddd050624e2e2d7f7
https://pubmed.ncbi.nlm.nih.gov/7753549
https://pubmed.ncbi.nlm.nih.gov/7753549
Publikováno v:
The British journal of radiology. 68(807)
The sensitivity of normal tissues rather than of the tumour usually limits the effectiveness of cancer treatment. The normal tissue side effects from chemotherapy and/or radiotherapy result from both direct cellular loss and the extensive fibrosis th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f9c9c378d33d9cac0ee7301b8bfea3d
https://pubmed.ncbi.nlm.nih.gov/7735779
https://pubmed.ncbi.nlm.nih.gov/7735779
Publikováno v:
Cancer research. 55(5)
The monoterpenes d-limonene and perillyl alcohol (POH) inhibit the growth of mammary tumors. In this investigation we tested whether POH is also effective in reducing liver tumor growth. Diethylnitrosamine was used to induce liver tumors in male Fisc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::419d3708cc49285d5e6ee1af2f671d78
https://pubmed.ncbi.nlm.nih.gov/7867007
https://pubmed.ncbi.nlm.nih.gov/7867007