Zobrazeno 1 - 10 of 105 pro vyhledávání: '"R L, Heinrikson"'
1
Large Scale Refolding and Purification of the Catalytic Domain of Human BACE-2 Produced in E. coli
Autor: A. M. Mildner, R. L. Heinrikson, H. D. Fischer, J. M. Lull, Thomas L. Emmons, Alfredo G. Tomasselli, J. W. Leone
Publikováno v: Protein & Peptide Letters. 16:121-131
Evidence for a key role of beta-amyloid (Abeta) in Alzheimer's disease has led to considerable interest in potential therapeutic strategies targeting enzymes involved in processing the amyloid precursor protein (APP). Beta-site APP Cleaving Enzyme (B
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153494af09ae75bfc3776dbf2125b283
https://doi.org/10.2174/092986609787316180
Zobrazit plný text záznamu
2
High Yield Expression of Human BACE Constructs in Eschericia coli for Refolding, Purification, and High Resolution Diffracting Crystal Forms
Autor: A. Tomasselli, D. Paddock, T. Emmons, A. Mildner, J. Leone, J. Lull, J. Cialdella, D. Prince, H. Fischer, R. Heinrikson, T. Benson, A. G. Tomasselli, D. J. Paddock, T. L. Emmons, A. M. Mildner, J. W. Leone, J. M. Lull, J. I. Cialdella, D. B. Prince, H. D. Fischer, R. L. Heinrikson, T. E. Benson
Publikováno v: Protein & Peptide Letters. 15:131-143
BACE (beta-site APP cleaving enzyme) or beta-secretase, the enzyme responsible for processing APP to give the N-terminal portion of the Abeta peptide, is a membrane bound aspartyl protease consisting of an ectodomain catalytic unit, a C-terminal tran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef55a7c8d6ffd247809d360890a6e53
https://doi.org/10.2174/092986608783489553
Zobrazit plný text záznamu
3
Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease
Autor: R L Heinrikson, J D Lowenson, I M Reardon, H A Zürcher-Neely, R J Cotter, Rong Wang, Melvyn J. Ball, Steven Clarke, C Wolkow, Alex E. Roher
Publikováno v: Journal of Biological Chemistry. 268:3072-3083
The structure of beta-amyloid (beta A) from Alzheimer disease brains was examined to determine if post-translational modifications might be linked to the abnormal deposition of this peptide in the diseased tissue. The beta A peptides were isolated fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce70b658f82e4721739981b382ce5b03
https://doi.org/10.1016/s0021-9258(18)53661-9
Zobrazit plný text záznamu
4
Nucleotide sequence and expression of the capsid protein gene of feline calicivirus
Autor: John D. Neill, I M Reardon, R L Heinrikson
Publikováno v: Journal of Virology. 65:5440-5447
The sequence of the 3'-terminal 2,486 bases of the feline calicivirus (FCV) genome was determined. This region of the FCV genome, from which the 2.4-kb subgenomic RNA is derived, contained two open reading frames. The larger open reading frame, found
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab738120c320337d1703b1e240deafe2
https://doi.org/10.1128/jvi.65.10.5440-5447.1991
Zobrazit plný text záznamu
5
Alzheimer's amyloid precursor protein produced by recombinant baculovirus expression. Proteolytic processing and protease inhibitory properties
Autor: R. L. Heinrikson, Patty Gonzalez-DeWhitt, Steven G. Younkin, J. M. Pasternack, C. S.C. Tomich, David E. Lowery, Barry D. Greenberg, H. Zurcher-Neely, R. A. Altman, M. B. Fairbanks
Publikováno v: Journal of Biological Chemistry. 266:19842-19850
The baculovirus expression system was used to generate recombinant Alzheimer's amyloid precursor (AAP) proteins. Recombinant baculoviruses were constructed, designed to express full-length 695-, 751-, and 770-amino acid forms. Recombinant baculovirus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6b046fe102d26d8064503f365138056
https://doi.org/10.1016/s0021-9258(18)55068-7
Zobrazit plný text záznamu
6
Half-life, hemodynamic, renal, and hormonal effects of prorenin in cynomolgus monkeys
Autor: Donald Marion, Tomas Lenz, Jean E. Sealey, John H. Laragh, Thomas Maack, R. L. Heinrikson, Gary D. James
Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 260:R804-R810
Prorenin is found in human plasma, kidneys, and reproductive organs. We investigated the physiological and pharmacokinetic properties of plasma prorenin, and its plasma conversion to active renin, by bolus infusions of human recombinant prorenin (0.5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451cf543bc92a8750bf246f756cae316
https://doi.org/10.1152/ajpregu.1991.260.4.r804
Zobrazit plný text záznamu
9
Sequence analysis of bovine lens aldose reductase
Autor: S L Early, C C Doughty, R L Heinrikson, F J Kézdy, T R Williams, C E Grimshaw, S Z Schade
Publikováno v: Journal of Biological Chemistry. 265:3628-3635
The covalent structure of bovine lens aldose reductase (alditol-NADP+ oxidoreductase, EC 1.1.1.21) was determined by sequence analysis of peptides generated by specific and chemical cleavage of the homogeneous apoenzyme. Peptides, purified by reverse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45dfa364eb1e732bed5c9ea3d13024cb
https://doi.org/10.1016/s0021-9258(19)39639-5
Zobrazit plný text záznamu
10
Cleaved high molecular weight kininogen binds directly to the integrin CD11b/CD18 (Mac-1) and blocks adhesion to fibrinogen and ICAM-1
Autor: N, Sheng, M B, Fairbanks, R L, Heinrikson, G, Canziani, I M, Chaiken, D M, Mosser, H, Zhang, R W, Colman
Publikováno v: Blood. 95(12)
High molecular weight kininogen (HK) and its cleaved form (HKa) have been shown to bind to neutrophils. Based on studies using monoclonal antibodies (mAbs), we postulated that CD11b/CD18 (Mac-1) might be the receptor on the neutrophils for binding to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3855f97f484d708a583bd823494e44de
https://pubmed.ncbi.nlm.nih.gov/10845911
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje