Výsledky vyhledávání - "R L, Heideman"

Diagnosis of hidden central hypothyroidism in survivors of childhood cancer

Autor: S R, Rose, R H, Lustig, P, Pitukcheewanont, D C, Broome, G A, Burghen, H, Li, M M, Hudson, L E, Kun, R L, Heideman

Publikováno v: The Journal of clinical endocrinology and metabolism. 84(12)

To determine how often central hypothyroidism remains undetected by routine out-patient tests of thyroid hormone, we studied 208 pediatric cancer survivors referred for evaluation because of signs of subtle hypothyroidism or hypopituitarism. Of the 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a8cac73141a1c550e44a04fe96e771aa
https://pubmed.ncbi.nlm.nih.gov/10599705

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O6-Methylguanine-DNA methyltransferase protein levels in pediatric brain tumors

Autor: S, Hongeng, T P, Brent, R A, Sanford, H, Li, L E, Kun, R L, Heideman

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(12 Pt 1)

Chloroethylnitrosoureas (CENUs) are commonly used in the treatment of pediatric and adult central nervous system (CNS) tumors. The antitumor activity of CENUs has been hypothesized to be due to an alkylation occurring at the O6-position of guanine in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c45d29309dc8cd269772c5eef8d5aec
https://pubmed.ncbi.nlm.nih.gov/9815647

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A four-hour topotecan infusion achieves cytotoxic exposure throughout the neuraxis in the nonhuman primate model: implications for treatment of children with metastatic medulloblastoma

Autor: W C, Zamboni, A J, Gajjar, T D, Mandrell, S L, Einhaus, M K, Danks, W P, Rogers, R L, Heideman, P J, Houghton, C F, Stewart

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(10)

The purpose of this study was to define the length of topotecan (TPT) i.v. infusion necessary to attain a cytotoxic exposure for medulloblastoma cells throughout the neuraxis. In vitro studies of human medulloblastoma cell lines (Daoy, SJ-Med3) were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03cda14788949a8fdca7f2ec12b00bef
https://pubmed.ncbi.nlm.nih.gov/9796988

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Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma

Autor: W C, Zamboni, A J, Gajjar, R L, Heideman, J H, Beijnen, H, Rosing, P J, Houghton, C F, Stewart

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(3)

Topotecan undergoes both renal and hepatic elimination, with topotecan urinary recovery ranging from 60 to 70%. We evaluated the potential of phenytoin to alter the disposition of topotecan and its N-desmethyl metabolite. A 5-year-old child with high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3bb577dde078c6e2c255426d9b466cd7
https://pubmed.ncbi.nlm.nih.gov/9533548

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Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization

Autor: D A, Reardon, E, Michalkiewicz, J M, Boyett, J E, Sublett, R E, Entrekin, S T, Ragsdale, M B, Valentine, F G, Behm, H, Li, R L, Heideman, L E, Kun, D N, Shapiro, A T, Look

Publikováno v: Cancer research. 57(18)

We analyzed 27 samples of primary medulloblastoma, using comparative genomic hybridization and a novel statistical approach to evaluate chromosomal regions for significant gain or loss of genomic DNA. An array of nonrandom changes was found in most s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5cc0459f6366052b4f3ad6b505720ae5
https://pubmed.ncbi.nlm.nih.gov/9307291

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Supratentorial malignant gliomas in childhood: a single institution perspective

Autor: R L, Heideman, J, Kuttesch, A J, Gajjar, A W, Walter, J J, Jenkins, Y, Li, R A, Sanford, L E, Kun

Publikováno v: Cancer. 80(3)

A retrospective study evaluated the clinical characteristics, prognostic factors, and outcome of patients with newly diagnosed supratentorial malignant gliomas treated with preirradiation chemotherapy.Of 41 patients with supratentorial malignant glio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fed0204803714d9351849221ead76f92
https://pubmed.ncbi.nlm.nih.gov/9241084

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Papillary thyroid carcinoma: demographics, treatment, and outcome in eleven pediatric patients treated at a single institution

Autor: M U, Kuefer, M, Moinuddin, R L, Heideman, R H, Lustig, S R, Rose, S, Burstein, L, VanMiddlesworth, I, Fleming, J J, Jenkins, P D, Shearer

Publikováno v: Medical and pediatric oncology. 28(6)

We describe 11 cases (8 females, 3 males) of papillary thyroid carcinoma in children treated at St. Jude Children's Research Hospital over a 33-year period, and review the literature. Ages ranged from 7-25 years (median, 16 years). Six patients had p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3123667fee89e42112b25b1842fb6b0d
https://pubmed.ncbi.nlm.nih.gov/9143389

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DNA index of glial tumors in children. Correlation with tumor grade and prognosis

Autor: P, Mathew, T, Look, X, Luo, R, Ashmun, M, Nash, A, Gajjar, A, Walter, L, Kun, R L, Heideman

Publikováno v: Cancer. 78(4)

Although DNA index (DI) has prognostic significance in a variety of pediatric malignancies, there are few data regarding its utility in central nervous system (CNS) tumors. We have previously shown that patients with hyperdiploid medulloblastoma have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::949c9a10cf91ae490ba34a340dcf657e
https://pubmed.ncbi.nlm.nih.gov/8756385

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