Zobrazeno 1 - 7
of 7
pro vyhledávání: '"R L, Dills"'
Publikováno v:
Risk analysis : an official publication of the Society for Risk Analysis. 19(6)
Physiologically-based toxicokinetic (PBTK) models are widely used to quantify whole-body kinetics of various substances. However, since they attempt to reproduce anatomical structures and physiological events, they have a high number of parameters. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0c2b77cff7c2496c89007eb0bdefa75
https://pubmed.ncbi.nlm.nih.gov/10765452
https://pubmed.ncbi.nlm.nih.gov/10765452
Publikováno v:
Journal of exposure analysis and environmental epidemiology. 4(2)
In vitro blood/air partition coefficients (KB/A) for acetone, 1,1,1-trichloroethane, toluene, and styrene were measured in blood samples from 73 human subjects and correlated with blood chemistry parameters (hematocrit, total cholesterol, serum trigl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6585e8bfbfc903699c9181be920b764
https://pubmed.ncbi.nlm.nih.gov/7549475
https://pubmed.ncbi.nlm.nih.gov/7549475
Publikováno v:
Journal of exposure analysis and environmental epidemiology. 3(4)
The equilibrium partitioning in closed systems method has been frequently used for determining partition coefficients between liquid and gas phases. We developed several improvements in this method: preparation of test atmospheres with a dynamic solv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11f314effac358b1909c681a158a47df
https://pubmed.ncbi.nlm.nih.gov/8173346
https://pubmed.ncbi.nlm.nih.gov/8173346
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 15(3)
Hepatic synthesis rates of UDP-glucose and UDP-glucuronic acid were determined in rats. Two high pressure liquid chromatographic methods were developed to quantitate and isolate UTP, UDP-glucose, and UDP-glucuronic acid from perchloric acid extracts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca1a20d41b0b908ce8e5f1b10fec56c0
https://pubmed.ncbi.nlm.nih.gov/2886300
https://pubmed.ncbi.nlm.nih.gov/2886300
Autor:
R L, Dills, C D, Klaassen
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 238(2)
The effect of decreased hepatic energy state on xenobiotic conjugation was examined in vivo. The pharmacokinetics of acetaminophen, a drug that is conjugated with glucuronic acid, sulfate and glutathione, was analyzed in rats when the hepatic energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47a961d075e33186a6f3441904a634c1
https://pubmed.ncbi.nlm.nih.gov/3735128
https://pubmed.ncbi.nlm.nih.gov/3735128
Autor:
R L, Dills, C D, Klaassen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 14(2)
The hepatic conjugation of xenobiotics with sulfate, glucuronic acid, and glutathione is decreased in vitro by compounds that impair cellular energy production. The proposed mechanism is that depletion of ATP in metabolically compromised cells causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8b378025ce16388bf3cccbe5749e894
https://pubmed.ncbi.nlm.nih.gov/2870893
https://pubmed.ncbi.nlm.nih.gov/2870893
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 13(1)
A rapid, sensitive, and specific procedure for the measurement of adenosine 3'-phosphate 5'-phosphosulfate (PAPS) in rat and mouse liver was developed. The method measures the formation of 1-[1-14C]naphthyl sulfate from 1-[1-14C]naphthol and PAPS (li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7be2d0b7d3cf58188eefd486d6314482
https://pubmed.ncbi.nlm.nih.gov/2858373
https://pubmed.ncbi.nlm.nih.gov/2858373