Zobrazeno 1 - 10
of 1 247
pro vyhledávání: '"R Kreutz"'
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-4 (2023)
Abstract Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMD
Externí odkaz:
https://doaj.org/article/f818bb40a99642d297f09ccc23c38f0e
Autor:
Katarzyna M. Grochowska, Marit Sperveslage, Rajeev Raman, Antonio V. Failla, Dawid Głów, Christian Schulze, Laura Laprell, Boris Fehse, Michael R. Kreutz
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112998- (2023)
Summary: The complex morphology of neurons poses a challenge for proteostasis because the majority of lysosomal degradation machinery is present in the cell soma. In recent years, however, mature lysosomes were identified in dendrites, and a fraction
Externí odkaz:
https://doaj.org/article/c3054975b675454d8630ed3d26b78003
Autor:
Maria Andres-Alonso, Maximilian Borgmeyer, Hadi Mirzapourdelavar, Jakob Lormann, Kim Klein, Michaela Schweizer, Sabine Hoffmeister-Ullerich, Anja M. Oelschlegel, Alexander Dityatev, Michael R. Kreutz
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112692- (2023)
Summary: The complex cytoarchitecture of neurons poses significant challenges for the maturation of synaptic membrane proteins. It is currently unclear whether locally secreted synaptic proteins bypass the Golgi or whether they traffic through Golgi
Externí odkaz:
https://doaj.org/article/cc25592f2ad74310b045450eed535d52
Autor:
Mary Muhia, PingAn YuanXiang, Jan Sedlacik, Jürgen R. Schwarz, Frank F. Heisler, Kira V. Gromova, Edda Thies, Petra Breiden, Yvonne Pechmann, Michael R. Kreutz, Matthias Kneussel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
A murine muskelin knockout induces increased exploratory drive and alters cognition and functional connectivity. These effects correlate with actin-dependent changes in dendritic branching, spine structure, and AMPAR-mediated synaptic transmission.
Externí odkaz:
https://doaj.org/article/2a57e15d62354e63a3239b6cceda15bf
Autor:
Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M. Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li, Katarzyna M. Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev, Michael R. Kreutz
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-18 (2022)
Abstract Background The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer's disease. It ha
Externí odkaz:
https://doaj.org/article/8050b454059242799298a70205d8078a
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-12 (2021)
Abstract Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requir
Externí odkaz:
https://doaj.org/article/a7fdade68a7246cf928274c363d333d6
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
Brain synapses pose special challenges on the quality control of their protein machineries as they are far away from the neuronal soma, display a high potential for plastic adaptation and have a high energy demand to fulfill their physiological tasks
Externí odkaz:
https://doaj.org/article/bbd43f596fb54ca9a8133a9e5ed0b10d
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
The role of sleep for brain function has been in the focus of interest for many years. It is now firmly established that sleep and the corresponding brain activity is of central importance for memory consolidation. Less clear are the underlying molec
Externí odkaz:
https://doaj.org/article/9909f9a4ad37438e81249454e655a576
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Pyramidal neurons exhibit a complex dendritic tree that is decorated by a huge number of spine synapses receiving excitatory input. Synaptic signals not only act locally but are also conveyed to the nucleus of the postsynaptic neuron to regulate gene
Externí odkaz:
https://doaj.org/article/89f3917176054208a268f29737d840f6
Autor:
Maximilian Borgmeyer, Cristina Coman, Canan Has, Hans-Frieder Schött, Tingting Li, Philipp Westhoff, Yam F.H. Cheung, Nils Hoffmann, PingAn Yuanxiang, Thomas Behnisch, Guilherme M. Gomes, Mael Dumenieu, Michaela Schweizer, Michaela Chocholoušková, Michal Holčapek, Marina Mikhaylova, Michael R. Kreutz, Robert Ahrends
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109797- (2021)
Summary: Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to prob
Externí odkaz:
https://doaj.org/article/598b45cadbbb4e3b8718c62af1798189