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Akademický článek

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Induced hybrid Treg/Th2 RAPA-501 cells for therapy of amyotrophic lateral sclerosis (ALS)

Autor: N. Zhu, Scott D. Rowley, S. Mosquera Limas, Michele L. Donato, R. Korngold, J. Berry, D. Glass, T. Felizardo, Daniel H. Fowler, J. Glass, P. Munshi, H. Bushera

Publikováno v: Cytotherapy. 23:S101-S102

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a65b6df1562b25256ee118ce75ba55d
https://doi.org/10.1016/s1465324921004308

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Peer review in hematopoietic cell transplantation: are we doing our fair share?

Autor: Hillard M. Lazarus, Sergio Giralt, R Korngold

Publikováno v: Bone marrow transplantation. 51(9)

Peer review is believed to be important in maintaining the quality and integrity of research in academic endeavors. Recently, the value of the current peer review process, which is more than 100 years old has come into question. In the field of hemat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03addee7a98055cc9255bf8be702735
https://pubmed.ncbi.nlm.nih.gov/27159173

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Repertoire Analysis of CD8+ T Cell Responses to Minor Histocompatibility Antigens Involved in Graft-Versus-Host Disease

Autor: T M, Friedman, M, Gilbert, C, Briggs, R, Korngold

Publikováno v: The Journal of Immunology. 161:41-48

Graft-vs-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation. Experimentally, lethal GVHD can be induced in MHC-matched strain combinations differing in expression of multiple minor histocompatibility Ags (miHA). Rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21b4cd90773a98f59dd108a945d9fac
https://doi.org/10.4049/jimmunol.161.1.41

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Anti-CD3 epsilon F(ab')2 fragments inhibit T cell expansion in vivo during graft-versus-host disease or the primary immune response to nominal antigen

Autor: B R Blazar, M K Jenkins, P A Taylor, J White, A Panoskaltsis-Mortari, R Korngold, D A Vallera

Publikováno v: The Journal of Immunology. 159:5821-5833

This study was undertaken to distinguish between several mechanisms responsible for graft-vs-host disease (GVHD) protection in anti-CD3epsilonF(ab')2 fragment (Fr)-treated recipients: TCR down-modulation, deletion, failure of expansion, or anergy ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff3fd7e13d1db0e1b00c0f718039aebe
https://doi.org/10.4049/jimmunol.159.12.5821

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Immune Cell Involvement inAnti-c-mycDNA Prevention of Tumor Formation in a Mouse Model of Burkitt'S Lymphoma

Autor: R. Townsend, R. Korngold, H. Hayasaka, Eric Wickstrom, G. D. Gray

Publikováno v: Nucleosides and Nucleotides. 16:1727-1730

Prophylactic therapy with 5′-dCACGTTGAGGGGCAT phosphorothioate, (2.5 nmol/hr) strongly inhibited tumorigenesis in Eμ-myc transgenic mice, and ablated spleen cell MYC antigen. However, the anti-c-myc DNA also stimulated proliferation of spleen cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::321be6864ba143ce9ea33e4f54a16bb2
https://doi.org/10.1080/07328319708006264

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Immunodominant CD4+ T cell receptor Vbeta repertoires involved in graft-versus-host disease responses to minor histocompatibility antigens

Autor: M A Berger, R Korngold

Publikováno v: The Journal of Immunology. 159:77-85

In vitro CTL responses to multiple minor histocompatibility Ags (miHA) are governed by immunodominance as demonstrated in the C57BL/6By (B6) anti-BALB.B strain combination. Immunodominance was also demonstrated to be operative in graft-vs-host diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::032c8c93aa700e79fcdaf6c57c1118c1
https://doi.org/10.4049/jimmunol.159.1.77

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Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation

Autor: B R Blazar, P A Taylor, A Panoskaltsis-Mortari, J Buhlman, J Xu, R A Flavell, R Korngold, R Noelle, D A Vallera

Publikováno v: The Journal of Immunology. 158:29-39

Alloreactive T cells require costimulatory signals via CD40 ligand (CD40L). The tissue-destructive properties of allogeneic CD4+ but not CD8+ T cells were inhibited by anti-CD40L mAb. Fewer CD4+ thoracic duct lymphocytes (TDL) were obtained in mAb-tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf975aeee70748f9371361b41bb4fe28
https://doi.org/10.4049/jimmunol.158.1.29

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A CD4-CDR3 peptide analog inhibits both primary and secondary autoreactive CD4+ T cell responses in experimental allergic encephalomyelitis

Autor: J C Marini, B A Jameson, F D Lublin, R Korngold

Publikováno v: The Journal of Immunology. 157:3706-3715

A structure-based design approach was used to develop a cyclized peptide analog of the murine CD4-CDR3-like region as a potential inhibitor of autoimmune CD4+ T cells responsible for the pathogenesis of experimental allergic encephalomyelitis (EAE).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edf99186ddac71139f8d8acbb7d50c16
https://doi.org/10.4049/jimmunol.157.8.3706

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