Zobrazeno 1 - 10
of 14
pro vyhledávání: '"R Kintzing"'
Autor:
Jennifer R. Cochran, Aaron K. Sato, Alexander Steiner, Maria Filsinger Interrante, Rishard Chen, James R. Kintzing, Shelley E. Ackerman, Nicolas V. Currier
Supplementary Figure 1. Standard curves for quantification of cellular integrin expression; Supplementary Figure 2. Competition binding to U87MG tumor cell surface integrins; Supplementary Figure 3. Inhibition of tumor cell proliferation. U87MG, A278
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9a80e014087983f673f0e0784b6f5b
https://doi.org/10.1158/1535-7163.22503807
https://doi.org/10.1158/1535-7163.22503807
Autor:
Hengameh Shams, M. Amin Arnaout, Jennifer R. Cochran, José Luis Alonso, Jian-Ping Xiong, James R. Kintzing, Johannes F. Van Agthoven, K. Grakami, Frank V. Cochran, Mohammad R. K. Mofrad
Integrins αVβ3 and α5β1 play critical roles in tumor survival, invasion, metastasis, and angiogenesis and are validated targets for cancer therapy and molecular imaging. Increasing evidence suggests that targeting both integrins simultaneously wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a319be9c185a4908e07aa91a9ac8e176
https://doi.org/10.1101/565358
https://doi.org/10.1101/565358
Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation
Publikováno v:
Angewandte Chemie International Edition. 55:9894-9897
Antibody-drug conjugates (ADCs) offer increased efficacy and reduced toxicity compared to systemic chemotherapy. Less attention has been paid to peptide-drug delivery, which has the potential for increased tumor penetration and facile synthesis. We r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01335e43cf3b6d5abf5e401277602c6f
https://doi.org/10.1002/anie.201603488
https://doi.org/10.1002/anie.201603488
Autor:
James R. Kintzing, Jennifer R. Cochran, Shelley Erin Ackerman, Nicolas V. Currier, Rishard Chen, Aaron K. Sato, Maria V. Filsinger Interrante, Alexander Steiner
Publikováno v:
Molecular Cancer Therapeutics. 15:1291-1300
Antibody–drug conjugates (ADC) have generated significant interest as targeted therapeutics for cancer treatment, demonstrating improved clinical efficacy and safety compared with systemic chemotherapy. To extend this concept to other tumor-targeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64a4533ce5880a415c9afe6bc123647
https://doi.org/10.1158/1535-7163.mct-15-0881
https://doi.org/10.1158/1535-7163.mct-15-0881
Autor:
James R. Kintzing, M. Amin Arnaout, Brian D. Adair, Hengameh Shams, Jian-Ping Xiong, Johannes F. Van Agthoven, Frank V. Cochran, Mohammad R. K. Mofrad, Jennifer R. Cochran, Kiavash Garakani, José Luis Alonso
Publikováno v:
Structure (London, England : 1993), vol 27, iss 9
Structure
Structure
Summary Targeting both integrins αVβ3 and α5β1 simultaneously appears to be more effective in cancer therapy than targeting each one alone. The structural requirements for bispecific binding of ligand to integrins have not been fully elucidated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06734a460c60f9cb078283e7fe68bf2
https://doi.org/10.1016/j.str.2019.06.011
https://doi.org/10.1016/j.str.2019.06.011
Autor:
Ann Hanna, Mukesh Kumar Gupta, Craig L. Duvall, James R. Kintzing, Joshua M. Shannon, Christopher E. Nelson
Publikováno v:
ACS Nano. 7:8870-8880
A family of pH-responsive diblock polymers composed of poly[(ethylene glycol)-b-[(2-(dimethylamino)ethyl methacrylate)-co-(butyl methacrylate)], PEG-(DMAEMA-co-BMA), was reversible addition-fragmentation chain transfer (RAFT) synthesized with 0-75 mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6116fd39b85f2a6833f19e6f5e65557
https://doi.org/10.1021/nn403325f
https://doi.org/10.1021/nn403325f
Autor:
James R. Kintzing, Jennifer R. Cochran
Publikováno v:
Current opinion in chemical biology. 34
Inhibitor cystine-knots, also known as knottins, are a structural family of ultra-stable peptides with diverse functions. Knottins and related backbone-cyclized peptides called cyclotides contain three disulfide bonds connected in a particular arrang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a01ee6553ebdd588df55911c90b264
https://pubmed.ncbi.nlm.nih.gov/27642714
https://pubmed.ncbi.nlm.nih.gov/27642714
Publikováno v:
Neurosurgical focus. 40(4)
Brain injuries are becoming increasingly common in athletes and represent an important diagnostic challenge. Early detection and management of brain injuries in sports are of utmost importance in preventing chronic neurological and psychiatric declin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c1c7808111d2ce46069cbee0f806f1
https://pubmed.ncbi.nlm.nih.gov/27032917
https://pubmed.ncbi.nlm.nih.gov/27032917
Autor:
Samuel H. Cheshier, Jennifer R. Cochran, Shelley Erin Ackerman, Gerald A. Grant, Darren A. Jindal, Christy Wilson, James R. Kintzing, Suzana Assad Kahn
Publikováno v:
Cureus
Tumors of the central nervous system are challenging to treat due to the limited effectiveness and associated toxicities of chemotherapy and radiation therapy. For tumors that can be removed surgically, extent of malignant tissue resection has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1379494fc63689edf6c1819bc273fdb8
https://doi.org/10.7759/cureus.207
https://doi.org/10.7759/cureus.207
Publikováno v:
Archives of Clinical Neuropsychology. 31:590.2-590
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd410b92f1ce43776461f48cf1656b81
https://doi.org/10.1093/arclin/acw043.18
https://doi.org/10.1093/arclin/acw043.18