Zobrazeno 1 - 10
of 267
pro vyhledávání: '"R Keith, Humphries"'
Autor:
Patrick Coulombe, Grace Cole, Amanda Fentiman, Jeremy D. K. Parker, Eric Yung, Misha Bilenky, Lemlem Degefie, Patrick Lac, Maggie Y. M. Ling, Derek Tam, R. Keith Humphries, Aly Karsan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Hematopoietic stem and progenitor cells (HSPCs) originate from an endothelial-to-hematopoietic transition (EHT) during embryogenesis. Characterization of early hemogenic endothelial (HE) cells is required to understand what drives hemogenic
Externí odkaz:
https://doaj.org/article/9daba83e40114d15ad6bf4ce80c79436
Autor:
Sophie Cardin, Mélanie Bilodeau, Mathieu Roussy, Léo Aubert, Thomas Milan, Loubna Jouan, Alexandre Rouette, Louise Laramée, Patrick Gendron, Jean Duchaine, Hélène Decaluwe, Jean-François Spinella, Stéphanie Mourad, Françoise Couture, Daniel Sinnett, Élie Haddad, Josette-Renée Landry, Jing Ma, R. Keith Humphries, Philippe P. Roux, Josée Hébert, Tanja A. Gruber, Brian T. Wilhelm, Sonia Cellot
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3307-3321 (2019)
Abstract: Acute megakaryoblastic leukemia (AMKL) represents ∼10% of pediatric acute myeloid leukemia cases and typically affects young children (
Externí odkaz:
https://doaj.org/article/a470cd10a4664d67873fc05b7a49373e
Autor:
Manabu Kusakabe, Ann Chong Sun, Kateryna Tyshchenko, Rachel Wong, Aastha Nanda, Claire Shanna, Samuel Gusscott, Elizabeth A. Chavez, Alireza Lorzadeh, Alice Zhu, Ainsleigh Hill, Stacy Hung, Scott Brown, Artem Babaian, Xuehai Wang, Robert A. Holt, Christian Steidl, Aly Karsan, R. Keith Humphries, Connie J. Eaves, Martin Hirst, Andrew P. Weng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Studies with patient derived xenografts are hampered by factors such as genetic variability and sample availability. Here, the authors generate a leukemia mouse model by lentiviral transduction of normal human cord blood and show an oncogenic role of
Externí odkaz:
https://doaj.org/article/0dc063f01a744a6691471a7f27cd84dc
Autor:
Hae-Ri Lee, Ga-Young Lee, Eung-Won Kim, Hee-Je Kim, Minho Lee, R. Keith Humphries, Il-Hoan Oh
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
Chemoresistance of leukemic cells has largely been attributed to clonal evolution secondary to accumulating mutations. Here, we show that a subset of leukemic blasts in contact with the mesenchymal stroma undergo cellular conversion into a distinct c
Externí odkaz:
https://doaj.org/article/bc6aebc79dd6475786e9859ed29906f2
Autor:
Ping Xiang, Wei Wei, Nicole Hofs, Jack Clemans-Gibbon, Tobias Maetzig, Courteney K. Lai, Ishpreet Dhillon, Christopher May, Jens Ruschmann, Edith Schneider, Patricia Rosten, Kaiji Hu, Florian Kuchenbauer, Pamela A. Hoodless, R. Keith Humphries
Publikováno v:
Blood Advances, Vol 1, Iss 24, Pp 2225-2235 (2017)
Abstract: Myeloid ecotropic viral integration site 1 (MEIS1), a HOX transcription cofactor, is a critical regulator of normal hematopoiesis, and its overexpression is implicated in a wide range of leukemias. Using the clustered regularly interspaced
Externí odkaz:
https://doaj.org/article/177ee9c1a2934b1bb4877ae28a97a7d0
Autor:
Tobias Maetzig, Jens Ruschmann, Lea Sanchez Milde, Courteney K. Lai, Niklas von Krosigk, R. Keith Humphries
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 54-65 (2017)
Tracking the behavior of leukemic samples both in vitro and in vivo plays an increasingly large role in efforts to better understand the leukemogenic processes and the effects of potential new therapies. Such work can be accelerated and made more eff
Externí odkaz:
https://doaj.org/article/6b595f88b78a4bd8ab97383d7c8c50df
Autor:
Patrick Coulombe, Grigorios N. Paliouras, Ashley Clayton, Angela Hussainkhel, Megan Fuller, Vida Jovanovic, Shauna Dauphinee, Patricia Umlandt, Ping Xiang, Alistair H. Kyle, Andrew I. Minchinton, R. Keith Humphries, Pamela A. Hoodless, Jeremy D.K. Parker, Joanne L. Wright, Aly Karsan
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1769-1780.e4 (2019)
Summary: The sterile alpha motif (SAM) and SRC homology 3 (SH3) domain containing protein 1 (Sash1) acts as a scaffold in TLR4 signaling. We generated Sash1−/− mice, which die in the perinatal period due to respiratory distress. Constitutive or e
Externí odkaz:
https://doaj.org/article/7da597faf600423285c07b09a097bc00
Autor:
Ping Xiang, Xining Yang, Leo Escano, Ishpreet Dhillon, Edith Schneider, Jack Clemans-Gibbon, Wei Wei, Jasper Wong, Simon Xufeng Wang, Derek Tam, Yu Deng, Eric Yung, Gregg B. Morin, Pamela A. Hoodless, Martin Hirst, Aly Karsan, Florian Kuchenbauer, R. Keith Humphries, Arefeh Rouhi
Publikováno v:
Leukemia. 36:1980-1989
Myeloid ecotropic virus insertion site 1 (MEIS1) is essential for normal hematopoiesis and is a critical factor in the pathogenesis of a large subset of acute myeloid leukemia (AML). Despite the clinical relevance of MEIS1, its regulation is largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75458bfaeff70dbcd6956dde0dcd2ed6
https://doi.org/10.1038/s41375-022-01602-4
https://doi.org/10.1038/s41375-022-01602-4
Autor:
Karina Barbosa, Anagha Deshpande, Marlenne Perales, Ping Xiang, Rabi Murad, Anna Minkina, Neil Robertson, Fiorella Schischlik, Xue Lei, Younguk Sun, Adam Brown, Diana Amend, Irmela Jeremias, John G. Doench, R. Keith Humphries, Eytan Ruppin, Jay Shendure, Prashant Mali, Peter D Adams, Aniruddha J. Deshpande
Aberrant expression of stem-cell-associated genes is a common feature in acute myeloid leukemia (AML) and is linked to leukemic self-renewal and therapy resistance. Using AF10-rearranged leukemia as a prototypical example displaying a recurrent “st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c2e098e719dc02ac374253fbf60e05d
https://doi.org/10.1101/2022.12.12.519332
https://doi.org/10.1101/2022.12.12.519332
Autor:
Edith Schneider, Anna Staffas, Linda Röhner, Erik D. Malmberg, Arghavan Ashouri, Kathrin Krowiorz, Nicole Pochert, Christina Miller, Stella Yuan Wei, Laleh Arabanian, Christian Buske, Hartmut Döhner, Lars Bullinger, Linda Fogelstrand, Michael Heuser, Konstanze Döhner, Ping Xiang, Jens Ruschmann, Oleh I. Petriv, Alireza Heravi-Moussavi, Carl L. Hansen, Martin Hirst, R. Keith Humphries, Arefeh Rouhi, Lars Palmqvist, Florian Kuchenbauer
Publikováno v:
Haematologica, Vol 103, Iss 2 (2018)
Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155
Externí odkaz:
https://doaj.org/article/87401d72d1534be9b48a6f1e53390dbc