A temperature-monitoring vaginal ring for measuring adherence.

Autor: Peter Boyd, Delphine Desjardins, Sandeep Kumar, Susan M Fetherston, Roger Le-Grand, Nathalie Dereuddre-Bosquet, Berglind Helgadóttir, Ásgeir Bjarnason, Manjula Narasimhan, R Karl Malcolm

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0125682 (2015)

Product adherence is a pivotal issue in the development of effective vaginal microbicides to reduce sexual transmission of HIV. To date, the six Phase III studies of vaginal gel products have relied primarily on self-reporting of adherence. Accurate

Externí odkaz: https://doaj.org/article/6267f1e9aa484458a3d37ec70a5f5fed

First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring

Autor: Willem de Laat, Lisa Pagan, R. Karl Malcolm, Maarten Wiegerinck, Victor Nickolson, Bertine Huisman, Rik Stuurman, Michiel van Esdonk, Naomi Klarenbeek

Publikováno v: Drug Delivery, Vol 30, Iss 1 (2023)

AbstractPolymeric drug-releasing vaginal rings are useful for both local and systemic administration of drugs via the intravaginal route. Typically, they provide continuous sustained or controlled release of drug(s) over extended time periods, thereb

Externí odkaz: https://doaj.org/article/4787f941be144ec396a0d86999b07d4b

Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings

Autor: Clare F. McCoy, Patrick Spence, Yahya H. Dallal Bashi, Diarmaid J. Murphy, Peter Boyd, Bindi Dangi, Tiffany Derrick, Bríd Devlin, Kyle Kleinbeck, R. Karl Malcolm

Publikováno v: International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100081- (2021)

Vaginal rings releasing antiretrovirals – either alone or in combination with contraceptive progestins – are being developed for prevention of human immunodeficiency virus (HIV) transmission via vaginal sex. Following Phase I trials, significant

Externí odkaz: https://doaj.org/article/33201504c4cc4078bdec85999ffab7fe

Preclinical development and pharmacokinetic assessment in macaques of a multipurpose long-acting injectable suspension containing medroxyprogesterone acetate for contraception and rilpivirine for HIV prevention

Autor: Clément M. Haeck, Peter Boyd, Nastasia Dimant, Aurélie Barrail-Tran, Hélène Gouget, Roger Le Grand, Delphine Desjardins, R. Karl Malcolm

Publikováno v: Haeck, C M, Boyd, P, Dimant, N, Barrail-Tran, A, Gouget, H, Le Grand, R, Desjardins, D & Malcolm, R K 2023, ' Preclinical development and pharmacokinetic assessment in macaques of a multipurpose long-acting injectable suspension containing medroxyprogesterone acetate for contraception and rilpivirine for HIV prevention ', Journal of Drug Delivery Science and Technology, vol. 85, 104590 . https://doi.org/10.1016/j.jddst.2023.104590

Depot injections comprising aqueous drug suspensions are widely marketed for long-acting administration of contraceptive progestins and antipsychotics. In recent years, there has been considerable interest in developing similar long-acting injectable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d7fe4b20d90db8626538b53308ade3
https://doi.org/10.1016/j.jddst.2023.104590

Pharmacological Approaches for the Prevention of Breast Implant Capsular Contracture

Autor: Eugénie Guimier, Louise Carson, Benny David, James M. Lambert, Enda Heery, R. Karl Malcolm

Publikováno v: Guimier, E, Carson, L, David, B, Lambert, J, Heery, E & Malcolm, K 2022, ' Pharmacological approaches for the prevention of breast implant capsular contracture ', Journal of Surgical Research, vol. 280, pp. 129–150 . https://doi.org/10.1016/j.jss.2022.06.073

Capsular contracture is a common complication associated with breast implants following reconstructive or aesthetic surgery in which a tight or constricting scar tissue capsule forms around the implant, often distorting the breast shape and resulting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b255df09cd4ef4cdc4196444278ba0
https://pubmed.ncbi.nlm.nih.gov/35969932