Zobrazeno 1 - 10
of 268
pro vyhledávání: '"R Karch"'
Autor:
Simone Sidoli, Congcong Lu, Mariel Coradin, Xiaoshi Wang, Kelly R. Karch, Chrystian Ruminowicz, Benjamin A. Garcia
Publikováno v:
Epigenetics & Chromatin, Vol 10, Iss 1, Pp 1-15 (2017)
Abstract Background Middle-down mass spectrometry (MS), i.e., analysis of long (~50–60 aa) polypeptides, has become the method with the highest throughput and accuracy for the characterization of combinatorial histone posttranslational modification
Externí odkaz:
https://doaj.org/article/37b4dca9d6b1409a856bf5de24c499d6
Publikováno v:
Annual review of biophysics. 51
Native mass spectrometry (nMS) has emerged as an important tool in studying the structure and function of macromolecules and their complexes in the gas phase. In this review, we cover recent advances in nMS and related techniques including sample pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00be2f787deb524406102b32b4d400d
https://pubmed.ncbi.nlm.nih.gov/34982572
https://pubmed.ncbi.nlm.nih.gov/34982572
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
Histone proteins are dynamically modified to mediate a variety of cellular processes including gene transcription, DNA damage repair, and apoptosis. Regulation of these processes occurs through the recruitment of non-histone proteins to chromatin by
Externí odkaz:
https://doaj.org/article/0c248f412f414f52a745ad2e66ec6d35
Rounding Out the Understanding of ACD Toxicity with the Discovery of Cyclic Forms of Actin Oligomers
Autor:
Dimitrios Vavylonis, Dmitri S. Kudryashov, Vicki H. Wysocki, Marcos Sotomayor, Harper Smith, David B. Heisler, Elena Kudryashova, Emil Reisler, Aaron R. Hall, Andrew Norris, Kelly R Karch, Nick Pinkerton
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 718, p 718 (2021)
Volume 22
Issue 2
International Journal of Molecular Sciences, Vol 22, Iss 718, p 718 (2021)
Volume 22
Issue 2
Actin is an essential element of both innate and adaptive immune systems and can aid in motility and translocation of bacterial pathogens, making it an attractive target for bacterial toxins. Pathogenic Vibrio and Aeromonas genera deliver actin cross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee875ad83402500401781a55eba35fcd
http://europepmc.org/articles/PMC7828245
http://europepmc.org/articles/PMC7828245
Autor:
Severin Weigand, Verena Semmler, Christian Grebmer, Sonia Busch, Carsten Lennerz, Christof Kolb, Patrick Blazek, Clara Deutschmann, Bernhard Haller, Martin R. Karch, Amir Brkic
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Therapy of choice for the primary and secondary prevention of sudden cardiac death is the implantation of an implantable cardioverter defibrillator (ICD). Whereas appropriate and inappropriate ICD shocks lead to myocardial microdamage, this is not kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8d1c1c82d49fd912a64e794f5d5fbe
https://doi.org/10.1038/s41598-020-61625-8
https://doi.org/10.1038/s41598-020-61625-8
Publikováno v:
Molecular BioSystems. 13:2660-2671
ADP-ribosylation is a protein post-translational modification catalyzed by ADP-ribose transferases (ARTs). ART activity is critical in mediating many cellular processes, and is required for DNA damage repair. All five histone proteins are extensively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489ec8f916feb6d3be257942db544bd4
https://doi.org/10.1039/c7mb00498b
https://doi.org/10.1039/c7mb00498b
Autor:
Helen Jiang, Kevin A. Janssen, Caroline Perry, Patrick M. Schaefer, Prasanth Potluri, Piotr K. Kopinski, Kathryn E. Wellen, Douglas C. Wallace, Larry N. Singh, Benjamin A. Garcia, Nathaniel W. Snyder, Mary T. Doan, Sophie Trefely, Eiko Nakamaru-Ogiso, Kelly R. Karch, Itzhak Nissim, Sydney L. Campbell, Jesus A Tintos-Hernandez
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mitochondrial DNA (mtDNA) mutations have been associated with common metabolic and degenerative disease phenotypes, implying a bioenergetic etiology for these diseases. For example, the mtDNA tRNALeu(UUR) m.3243A > G mutation manifests a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a22bc52feb5782e4948eca2dfc7619
https://pubmed.ncbi.nlm.nih.gov/31308238
https://pubmed.ncbi.nlm.nih.gov/31308238
Autor:
Mechthild Pohlschroder, Mohd Farid Abdul Halim, Yitian Zhou, Benjamin A. Garcia, Kelly R. Karch, Daniel H. Haft
Publikováno v:
Journal of Bacteriology. 198:808-815
For years, the S-layer glycoprotein (SLG), the sole component of many archaeal cell walls, was thought to be anchored to the cell surface by a C-terminal transmembrane segment. Recently, however, we demonstrated that the Haloferax volcanii SLG C term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56a208ad7c47ba5d56ae89f4156d4f7
https://doi.org/10.1128/jb.00849-15
https://doi.org/10.1128/jb.00849-15
Autor:
S. Walter Englander, Kelly R. Karch, Zhong-yuan Kan, Ben E. Black, Mariel Coradin, Morgan Gerace, Levani Zandarashvili, Benjamin A. Garcia
Until recently, a major limitation of hydrogen deuterium exchange mass spectrometry (HDX-MS) was that resolution of deuterium localization information was limited to the length of the peptide generated during proteolysis. Recently, however, it has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dada545274a2e3b0fe1e1a371b0796cb
https://doi.org/10.1101/310177
https://doi.org/10.1101/310177
Autor:
Carsten Lennerz, Verena Semmler, Kazuaki Kaitani, Christian Grebmer, Christof Kolb, Hrvoje Vražić, Boris Starčević, Jerko Ferri-Certić, Patrick Blažek, Martin R. Karch
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
Fixation of the pacemaker leads during pacemaker implantation leads to an increase of cardiac Troponin T (cTnT) that can be interpreted as a sign of minimal myocardial damage. This trial evaluates whether the mechanism type of lead fixation influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aef8825e7b4d1dc3d51159bad1008d2
https://doi.org/10.1038/s41598-018-23209-5
https://doi.org/10.1038/s41598-018-23209-5