Výsledky vyhledávání

Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible

Autor: Joyce F. Clark, Twanda L. Thirkill, Fitz Roy E Curry, Roger H. Adamson, R K Sarai, A Altangerel

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 302:H1929-H1935

To evaluate the hypothesis that sphingosine-1-phosphate (S1P) and cAMP attenuate increased permeability of individually perfused mesenteric microvessels through a common Rac1-dependent pathway, we measured the attenuation of the peak hydraulic conduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e329024c2e6f5dd7265b8c5f0760c65e
https://doi.org/10.1152/ajpheart.00614.2011

Zobrazit plný text záznamu

Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels

Autor: Twanda L. Thirkill, Roger H. Adamson, A Altangerel, Joyce F. Clark, Fitz Roy E Curry, R K Sarai

Publikováno v: Cardiovascular Research. 88:344-351

Aims Although several cultured endothelial cell studies indicate that sphingosine-1-phosphate (S1P), via GTPase Rac1 activation, enhances endothelial barriers, very few in situ studies have been published. We aimed to further investigate the mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b190b1f1f479238c5df50369e564d18
https://doi.org/10.1093/cvr/cvq184

Zobrazit plný text záznamu

Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery

Autor: Fitz Roy E Curry, A Altangerel, Joyce F. Lenz, Detlev Drenckhahn, J. C. Ly, R K Sarai, Roger H. Adamson

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 294:H1188-H1196

Experiments in cultured endothelial cell monolayers demonstrate that increased intracellular cAMP strongly inhibits the acute permeability responses by both protein kinase A (PKA)-dependent and -independent pathways. The contribution of the PKA-indep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65842e4967422c35f28ae4f33b36df11
https://doi.org/10.1152/ajpheart.00937.2007

Zobrazit plný text záznamu

Microvascular permeability to water is independent of shear stress, but dependent on flow direction

Autor: A Altangerel, Joyce F. Clark, Roger H. Adamson, Fitz Roy E Curry, Sheldon Weinbaum, R K Sarai

Endothelial cells in a cultured monolayer change from a “cobblestone” configuration when grown under static conditions to a more elongated shape, aligned with the direction of flow, after exposure to sustained uniform shear stress. Sustained bloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d0e4849db8e60eefe8000dad4e9773
https://europepmc.org/articles/PMC3625907/