Výsledky vyhledávání

Cyclic AMP-independent effects of cholera toxin on B cell activation. II. Binding of ganglioside GM1 induces B cell activation

Autor: M L Francis, J Ryan, M G Jobling, R K Holmes, J Moss, J J Mond

Publikováno v: The Journal of Immunology. 148:1999-2005

Although the physiologic function of gangliosides is unknown, evidence suggests they play a role in the regulation of cell growth. The binding of ganglioside GM1 by recombinant B subunit of cholera toxin (rCT-B) inhibited mitogen-stimulated B cell pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::321d1b820d81b3a3f0e107f9c86ad776
https://doi.org/10.4049/jimmunol.148.7.1999

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Akademický článek

Rural Hospital Service Lines: Changes Over Time and Impacts on Profitability.

Autor: Whitacre BE; Department of Agricultural Economics, Oklahoma State University, Stillwater, Oklahoma; and., Rhoades CA, Davis AF; Center for Economic Analysis of Rural Health, Department of Agricultural Economics, University of Kentucky, Lexington, Kentucky.

Publikováno v: Journal of healthcare management / American College of Healthcare Executives [J Healthc Manag] 2024 Sep-Oct 01; Vol. 69 (5), pp. 350-367. Date of Electronic Publication: 2024 Sep 06.

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Characterization of hapR, a positive regulator of the Vibrio cholerae HA/protease gene hap, and its identification as a functional homologue of the Vibrio harveyi luxR gene

Autor: M G, Jobling, R K, Holmes

Publikováno v: Molecular microbiology. 26(5)

The Vibrio cholerae HA/protease gene (hap) promoter is inactive in Escherichia coli. We cloned and sequenced the 0.7kb hap promoter fragment from strain 3083-2 and showed that hap is located immediately 3' of ompW, encoding a minor outer membrane pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e5babb632c6014b725744ec9fec388d
https://pubmed.ncbi.nlm.nih.gov/9426139

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Proteolytic activation of cholera toxin and Escherichia coli labile toxin by entry into host epithelial cells. Signal transduction by a protease-resistant toxin variant

Autor: W I, Lencer, C, Constable, S, Moe, P A, Rufo, A, Wolf, M G, Jobling, S P, Ruston, J L, Madara, R K, Holmes, T R, Hirst

Publikováno v: The Journal of biological chemistry. 272(24)

Cholera and Escherichia coli heat-labile toxins (CT and LT) require proteolysis of a peptide loop connecting two major domains of their enzymatic A subunits for maximal activity (termed "nicking"). To test whether host intestinal epithelial cells may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1db96271abd0fed0fc4821fe83f532c
https://pubmed.ncbi.nlm.nih.gov/9182593

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Cloning and characterization of hemolytic genes from Helicobacter pylori

Autor: R K Holmes, A Dubois, N S Akopyants, Douglas E. Berg, Richard L. Warren, E S Drazek, D Kersulyte

Publikováno v: Infection and immunity. 63(11)

Strains of Helicobacter pylori, the bacterium associated with gastritis, peptic ulcer disease, and gastric cancer in humans, express different degrees of hemolysis on agar containing erythrocytes (RBC). Here we report the isolation and characterizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40ce117fa40840336fd506d1eb58f25
https://pubmed.ncbi.nlm.nih.gov/7591069

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Initial studies of the structural signal for extracellular transport of cholera toxin and other proteins recognized by Vibrio cholerae

Autor: R. K. Holmes, Terry D. Connell, Minglun Wang, Michael G. Jobling, Daniel J. Metzger

Publikováno v: Infection and immunity. 63(10)

The specificity of the pathway used by Vibrio cholerae for extracellular transport of cholera toxin (CT) and other proteins was examined in several different ways. First, V. cholerae was tested for the ability to secrete the B polypeptides of the typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba6296b63f2164ce5d19e8281f17e80
https://pubmed.ncbi.nlm.nih.gov/7558324

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Activation of Escherichia coli heat-labile enterotoxins by native and recombinant adenosine diphosphate-ribosylation factors, 20-kD guanine nucleotide-binding proteins

Autor: Joel Moss, B. C. Kunz, E. M. Twiddy, Ronald Adamik, S. R. Price, R. K. Holmes, Chii-Ming Lee, Su-Chen Tsai, Patrick P. Chang

Publikováno v: Scopus-Elsevier

Escherichia coli heat-labile enterotoxins (LT) are responsible in part for "traveler's diarrhea" and related diarrheal illnesses. The family of LTs comprises two serogroups termed LT-I and LT-II; each serogroup includes two or more antigenic variants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065eac5908940d4705f4794f360ec8b3
https://pubmed.ncbi.nlm.nih.gov/1902492

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