Zobrazeno 1 - 10
of 32
pro vyhledávání: '"R K B, Pearce"'
Publikováno v:
Neuroscience. 115:1047-1058
Chronic administration of L-DOPA to MPTP-treated common marmosets induces marked dyskinesia while repeated administration of equivalent antiparkisonian doses of ropinirole and bromocriptine produces only mild involuntary movements. The occurrence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aaaa4759546d535e6282105c353d8f
https://doi.org/10.1016/s0306-4522(02)00535-3
https://doi.org/10.1016/s0306-4522(02)00535-3
Publikováno v:
Psychopharmacology. 156:402-409
Rationale:L-Dopa induces dyskinesias during the treatment of Parkinson's disease and also in primates with nigrostriatal lesions produced by MPTP, but it is claimed that L-dopa does not provoke dyskinesia in humans or monkeys with an intact or mildly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76c25bf00f4d1dcc0b579b3a60df9b9
https://doi.org/10.1007/s002130100733
https://doi.org/10.1007/s002130100733
Autor:
R. K. B. Pearce, Sergio Costa, Mahmoud M. Iravani, Banu C. Tel, Michael J. Jackson, Peter Jenner, Carla Cannizzaro
Publikováno v:
European Journal of Neuroscience. 13:597-608
Parkinson's disease (PD) is associated with a progressive loss of dopamine neurons in the substantia nigra and degeneration of dopaminergic terminals in the striatum. Although L-DOPA treatment provides the most effective symptomatic relief for PD it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0664c4804a690dd8ccfc78455246294c
https://doi.org/10.1046/j.1460-9568.2001.01408.x
https://doi.org/10.1046/j.1460-9568.2001.01408.x
Autor:
R. K. B. Pearce, B.C. Tel, L. Chancharme, L. A. Smith, Bai-Yun Zeng, G. Moachon, Peter Jenner
Publikováno v:
Experimental Brain Research. 133:178-188
The psychostimulant drug, modafinil, protects rodents against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity, striatal ischemia and partial transection of the nigro-striatal pathway. We now report on the ability of modafinil to reverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce40f98187463ed1698e36aba26b327
https://doi.org/10.1007/s002210000370
https://doi.org/10.1007/s002210000370
Publikováno v:
European Journal of Neuroscience. 12:1096-1104
Chronic treatment with L-DOPA induces dyskinesia in patients with Parkinson's disease (PD) and 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP)-treated monkeys, but is not thought to do so in normal humans or primates. However, we have shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f926dce75013d6651320effbc74f0e3
https://doi.org/10.1046/j.1460-9568.2000.00988.x
https://doi.org/10.1046/j.1460-9568.2000.00988.x
Publikováno v:
Journal of Neural Transmission. 106:663-683
BDNF or vehicle were administered by unilateral supranigral infusion in normal and chronically lesioned MPTP-treated common marmosets (Callithrix jacchus) for four weeks and locomotor activity, disability and response to apomorphine were assessed wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423e3a9665b8b65e464c8dd22526abaa
https://doi.org/10.1007/s007020050188
https://doi.org/10.1007/s007020050188
Autor:
Joseph Jankovic, Ann C. McKee, Eugene C. Lai, Irene Litvan, Yves Agid, John J. Bartko, Gregor K. Wenning, Christopher G. Goetz, Marc Verny, K. Jellinger, Kallol Ray Chaudhuri, Jean-Philippe Brandel, R. K. B. Pearce, V. Booth
Publikováno v:
Journal of Neural Transmission. 105:217-227
We estimated the accuracy of a modified commonly used set of clinical diagnostic criteria for the diagnosis of multiple system atrophy (MSA) by retrospectively applying the criteria to the features recorded by six neurologists who had evaluated 105 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0834e096aaf56da6925eaf2403dd5e
https://doi.org/10.1007/s007020050050
https://doi.org/10.1007/s007020050050
Autor:
Ann C. McKee, Marc Verny, L. D'Olhaberriague, Irene Litvan, Kallol Ray Chaudhuri, G. Campbell, Carlos A. Mangone, K. Jellinger, R. K. B. Pearce
Publikováno v:
Brain. 120:65-74
The difficulty in differentiating progressive supranuclear palsy (PSP, also called Steele-Richardson-Olszewski syndrome) from other related disorders was the incentive for a study to determine the clinical features that best distinguish PSP. Logistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29578df4b0d247095315c773c2c247fa
https://doi.org/10.1093/brain/120.1.65
https://doi.org/10.1093/brain/120.1.65
Autor:
R. K. B. Pearce
Publikováno v:
Expert Opinion on Therapeutic Patents. 6:949-953
While early experience with D1 receptor agonists in Parkinson's disease (PD) was disappointing, more recent work, especially in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated parkinsonian monkeys, has shown that D1 selective receptor ago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd2f1a9740434ec339122c968f252179
https://doi.org/10.1517/13543776.6.10.949
https://doi.org/10.1517/13543776.6.10.949
Publikováno v:
Synapse. 23:192-200
Basic fibroblast growth factor (bFGF) prevents damage to the nigrostriatal system in rodents. We now report the effects of bFGF administered by intraventricular infusion to adult common marmosets (Callithrix jacchus) previously rendered parkinsonian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04308c3ecbf3948860f568a6e0e97650
https://doi.org/10.1002/(sici)1098-2396(199607)23:3<192::aid-syn8>3.0.co
https://doi.org/10.1002/(sici)1098-2396(199607)23:3<192::aid-syn8>3.0.co