Zobrazeno 1 - 10
of 338
pro vyhledávání: '"R K, Winn"'
Autor:
R. K. Winn, J. M. Harlan
Publikováno v:
Journal of Thrombosis and Haemostasis. 3:1815-1824
The integrity of the endothelial lining of the vasculature is essential for vascular homeostasis and normal organ function. Endothelial injury or dysfunction has been implicated in the pathogenesis of diverse vascular diseases. Studies in vitro have
Publikováno v:
Scandinavian Journal of Immunology. 56:588-592
Background: Both C1-inhibitor (C1-INH) and antibodies against the CD18 adhesion molecule have been shown to reduce ischaemia–reperfusion injuries. The objective of this study was to investigate the effect of increased ischaemia times and to determi
Publikováno v:
The Journal of Immunology. 159:943-951
E-selectin (CD62E) is a cytokine-inducible endothelial cell adhesion molecule that tethers polymorphonuclear leukocytes (PMNs) and supports PMN rolling under conditions of flow. We examined whether interaction of PMNs with E-selectin also leads to ac
Publikováno v:
The Journal of Immunology. 157:2555-2563
Neutrophil (PMN) recruitment into systemic inflammatory sites in vivo is thought to be initiated by selectin-mediated endothelial adherence. We explored the role of L-selectin (CD62L) in leukocyte emigration following instillation of bacteria into th
Publikováno v:
The Journal of Immunology. 155:4011-4015
Ischemia-reperfusion injury in the rabbit ear is neutrophil (PMN)-mediated, and is significantly reduced by anti-adhesion agents directed against beta 2 integrins, P-selectin, or L-selectin. We further examined selectin-mediated adherence in this set
Publikováno v:
The Journal of Immunology. 153:2234-2238
mAb blockade of CD18-mediated neutrophil adherence has previously been shown to reduce tissue injury in the rabbit ear as a result of ischemia followed by reperfusion. Similar injury reduction has been demonstrated whether treatment is given before i
Publikováno v:
Journal of Applied Physiology. 76:86-90
Monoclonal antibody (MAb) 60.3 recognizes the leukocyte CD18 glycoprotein and ameliorates much of the injury after hemorrhagic shock in rabbits and nonhuman primates. This MAb blocks neutrophil emigration and has been shown to increase the risk of in
Publikováno v:
Journal of Leukocyte Biology. 53:511-517
Hepatic ischemia-reperfusion injury is reported to be modulated by neutrophils (PMNs). The adhesion and emigration of PMNs that precede tissue inflammation and necrosis in other organs are mediated, in part, by the leukocyte adhesion complex CD11/CD1
Autor:
J. H. Harris, R. K. Winn
Publikováno v:
Applied optics. 14(5)
Theoretical coupling of a guided Gaussian beam in a planar dielectric waveguide to a rectangular waveguide using a lenslike coupling region is investigated. The coupling region is formed by varying the thickness of the planar waveguide. When the cent
Publikováno v:
The Journal of Immunology. 144:2327-2333
Neutrophil (PMN) migration in the systemic and pulmonary circulation of rabbits was compared by using different inflammatory stimuli to determine the role of the leukocyte adhesion complex, CD11/CD18, in each of these vascular beds. The adhesion comp