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Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells

Autor: B, Scaglione-Sewell, C, Abraham, M, Bissonnette, S F, Skarosi, J, Hart, N O, Davidson, R K, Wali, B H, Davis, M, Sitrin, T A, Brasitus

Publikováno v: Cancer research. 58(5)

Previous studies have shown that PKC-alpha protein expression is decreased in sporadic human colon cancers, as well as in colonic tumors of rats induced by chemical carcinogens. To elucidate the potential role of PKC-alpha on several phenotypic chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44ce20f7c40ca0814620947047e7baff
https://pubmed.ncbi.nlm.nih.gov/9500474

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Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta

Autor: R K, Wali, B P, Frawley, S, Hartmann, H K, Roy, S, Khare, B A, Scaglione-Sewell, D L, Earnest, M D, Sitrin, T A, Brasitus, M, Bissonnette

Publikováno v: Cancer research. 55(22)

Several lines of evidence from our laboratory and others indicate that epigenetic alterations in protein kinase C (PKC) are involved in colonic carcinogenesis in both man and experimental animals. Furthermore, bile salts, known activators of PKC, hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::897d2f49668c074bbfd17d7ca70a6869
https://pubmed.ncbi.nlm.nih.gov/7585585

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1 alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, a noncalcemic analogue of 1 alpha,25-dihydroxyvitamin D3, inhibits azoxymethane-induced colonic tumorigenesis

Autor: R K, Wali, M, Bissonnette, S, Khare, J, Hart, M D, Sitrin, T A, Brasitus

Publikováno v: Cancer research. 55(14)

Vitamin D3 and its metabolites, particularly 1 alpha,25-dihydroxyvitamin D3 (1 alpha, 25(OH)2D3), have received increasing attention as potential anticarcinogens in the prevention of cancers in a number of organs, including the colon. These agents, h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::131fc77f5b6defebac600b0b9c06ec37
https://pubmed.ncbi.nlm.nih.gov/7606726

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Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid

Autor: D L, Earnest, H, Holubec, R K, Wali, C S, Jolley, M, Bissonette, A K, Bhattacharyya, H, Roy, S, Khare, T A, Brasitus

Publikováno v: Cancer research. 54(19)

The present studies were conducted at the Universities of Chicago and Arizona to examine and compare the effects of supplemental dietary ursodeoxycholic acid to cholic acid, a known tumor promoter, and to piroxicam, a known chemopreventive agent, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::642236d1d9407b0302d235818856df29
https://pubmed.ncbi.nlm.nih.gov/7923119

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1,2-Dimethylhydrazine-induced alterations in protein kinase C activity in the rat preneoplastic colon

Autor: C L, Baum, R K, Wali, M D, Sitrin, M J, Bolt, T A, Brasitus

Publikováno v: Cancer research. 50(13)

Recently, a number of studies in experimental animals and humans have suggested that alterations in the activity of protein kinase C (PKC) may be involved in the malignant transformation process. To determine whether such alterations in this kinase w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e931eadc493271550f9982e9b9042da
https://pubmed.ncbi.nlm.nih.gov/2162248

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Effect of a single oral dose of endosulfan on intestinal uptake of nutrients and on brush-border enzymes in rats

Autor: Pradeep K. Dudeja, A. Mahmood, R. K. Wali, Raj Singh

Publikováno v: Toxicology Letters. 12:7-12

The effect of a single oral dose of endosulfan (5 mg/kg body weight) on the uptake of certain nutrients and brush-border enzymes has been studied in rat intestine. The uptake of glucose and alanine was elevated but that of leucine was decreased in en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb57496071ca3670fe79bf1944cb68db
https://doi.org/10.1016/0378-4274(82)90191-6

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