Zobrazeno 1 - 10
of 20
pro vyhledávání: '"R K, Brazzell"'
Publikováno v:
Pharmaceutical Research. :469-473
To investigate the hypothesis that the pharmacokinetics of imirestat, an aldose reductase inhibitor, are influenced by saturable binding to tissues, three experiments were done. (1) The nature of the dose dependence was characterized in rats. Two gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e3ff5f8978ca6169e9850a513a91463
https://doi.org/10.1023/a:1015880011131
https://doi.org/10.1023/a:1015880011131
Publikováno v:
British Journal of Clinical Pharmacology. 32:221-227
1. The metabolism of the aldose reductase inhibitor, ALO1567, was studied in man. The major biotransformation pathway was aromatic hydroxylation followed by glucuronide conjugation. 2. Hydroxylation occurred at several positions on the fluorene ring.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcea464d672e9b4e866a303914abc1e1
https://doi.org/10.1111/j.1365-2125.1991.tb03885.x
https://doi.org/10.1111/j.1365-2125.1991.tb03885.x
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 565:255-264
A sensitive and selective gas chromatographic-electron-capture assay was developed for the determination of the aldose reductase inhibitor imirestat in lens and plasma. The method involves solid-phase extraction of drug and internal standard from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676e675840448973aae76edd2d0bf83f
https://doi.org/10.1016/0378-4347(91)80388-s
https://doi.org/10.1016/0378-4347(91)80388-s
Publikováno v:
Pharmaceutical Research. :112-118
The pharmacokinetics of imirestat were studied in healthy volunteers following single and multiple oral doses. After single doses of 20 to 50 mg, imirestat plasma concentrations declined with an apparent elimination half-life of 50 to 70 hr over the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4905751d03bdb1a69f9e8c0d3d118202
https://doi.org/10.1023/a:1015850911382
https://doi.org/10.1023/a:1015850911382
Publikováno v:
Pharmaceutical Research. :1198-1200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dafa20f90d3c4051af59b746529c2cf0
https://doi.org/10.1023/a:1015952930541
https://doi.org/10.1023/a:1015952930541
Publikováno v:
Pharmaceutical research. 9(4)
To investigate the hypothesis that the pharmacokinetics of imirestat, an aldose reductase inhibitor, are influenced by saturable binding to tissues, three experiments were done. (1) The nature of the dose dependence was characterized in rats. Two gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a328cee46678522c508535edffb8dd12
https://pubmed.ncbi.nlm.nih.gov/1495891
https://pubmed.ncbi.nlm.nih.gov/1495891
Publikováno v:
Pharmaceutical research. 7(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ebf2fde3f997f4b59347e904a4ab4cdc
https://pubmed.ncbi.nlm.nih.gov/2127314
https://pubmed.ncbi.nlm.nih.gov/2127314
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 18(4)
The pharmacokinetics of three aldose reductase inhibitors (ARIs) were evaluated in various species, including rat, dog, cynomolgus monkey, rhesus monkey, chimpanzee, and man. The three ARIs (AL01567, AL01576, and AL01750) were administered intravenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::128ddcfa3d65e6d06274fd57091264d1
https://pubmed.ncbi.nlm.nih.gov/1976064
https://pubmed.ncbi.nlm.nih.gov/1976064
Pharmacokinetics of the aldose reductase inhibitor imirestat following topical ocular administration
Publikováno v:
Pharmaceutical research. 7(2)
The pharmacokinetics of imirestat following topical ocular administration were evaluated in a series of studies in rabbits and dogs. Following single topical doses to both albino and pigmented rabbits, imirestat was subject to rapid uptake into the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2985ff77613bbe7abe22d7cfff8dab3d
https://pubmed.ncbi.nlm.nih.gov/2106677
https://pubmed.ncbi.nlm.nih.gov/2106677
Autor:
R. K. Brazzell, Wayne A. Colburn
Publikováno v:
The Journal of Clinical Pharmacology. 26:242-247
Many factors should be considered when choosing an appropriate population for a pharmacokinetic trial. Although there are some generalities that apply to most studies, each investigation must be judged separately, since the relevant considerations wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467db3bc6a247e9536dc8b5d9273a10a
https://doi.org/10.1002/j.1552-4604.1986.tb03517.x
https://doi.org/10.1002/j.1552-4604.1986.tb03517.x