Zobrazeno 1 - 10
of 247
pro vyhledávání: '"R Jude Samulski"'
Autor:
Gensheng Wang, Christopher H Evans, Janet M Benson, Julie A Hutt, JeanClare Seagrave, Julie A Wilder, Joshua C Grieger, R Jude Samulski, Pramod S Terse
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Interleukin-1 (IL-1) plays an important role in the pathophysiology of osteoarthritis (OA), and gene transfer of IL-1 receptor antagonist (IL-1Ra) holds promise for OA treatment. A preclinical safety and biodistribution study evaluated a self-complem
Externí odkaz:
https://doaj.org/article/6c9baaef7b4e465f9ba978ec9d3129c7
Autor:
Haibo Wang, Xiaokun Han, Colin A Bretz, Silke Becker, Deeksha Gambhir, George W Smith, R Jude Samulski, Erika S Wittchen, Lawrence A Quilliam, Magdalena Chrzanowska-Wodnicka, M Elizabeth Hartnett
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
To test the hypothesis that increased Rap1a activity specifically in retinal pigment epithelial cells resists choroidal neovascularization (CNV), self-complementary adeno-associated virus 2 (scAAV2) with RPE65-promoter-driven GFP vectors were generat
Externí odkaz:
https://doaj.org/article/cd8e2b0f679940ba84f1a0b4c6314f90
Autor:
Lei Ye, Haisheng Yu, Chengwen Li, Matthew L Hirsch, Liguo Zhang, R Jude Samulski, Wuping Li, Zhong Liu
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130052 (2015)
Liver cirrhosis and hepatocellular carcinomas are major health problems of chronic hepatitis B virus (HBV) infection. To date, rare model has reproduced liver fibrosis associated with long-term HBV infection which in turn has hindered both the unders
Externí odkaz:
https://doaj.org/article/b38b1b905d444f5a9867b60f33cabb76
Autor:
Incilay Sinici, Sayuri Yonekawa, Ilona Tkachyova, Steven J Gray, R Jude Samulski, Warren Wakarchuk, Brian L Mark, Don J Mahuran
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57908 (2013)
The hydrolysis in lysosomes of GM2 ganglioside to GM3 ganglioside requires the correct synthesis, intracellular assembly and transport of three separate gene products; i.e., the alpha and beta subunits of heterodimeric beta-hexosaminidase A, E.C. # 3
Externí odkaz:
https://doaj.org/article/4df25f80c5ab47469e0a8236857830c9
Autor:
Laurie R Goodrich, Jennifer N Phillips, C Wayne McIlwraith, Stacey B Foti, Joshua C Grieger, Steven J Gray, R Jude Samulski
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Osteoarthritis (OA) affects over 40 million people annually. We evaluated interleukin-1 receptor antagonist (IL-1ra) gene transfer in an equine model based on IL-1ra protein therapy which inhibits inflammation through blocking IL-1. Using the self-co
Externí odkaz:
https://doaj.org/article/37ec94c02cc0465d9a142c8a9067e082
Autor:
Jarrod S Johnson, Martina Gentzsch, Liqun Zhang, Carla M P Ribeiro, Boris Kantor, Tal Kafri, Raymond J Pickles, R Jude Samulski
Publikováno v:
PLoS Pathogens, Vol 7, Iss 5, p e1002053 (2011)
Barriers to infection act at multiple levels to prevent viruses, bacteria, and parasites from commandeering host cells for their own purposes. An intriguing hypothesis is that if a cell experiences stress, such as that elicited by inflammation, endop
Externí odkaz:
https://doaj.org/article/2b7946ef397d4a6e8d1c9ac73552aa52
Autor:
Matthew L Hirsch, B Matthew Fagan, Raluca Dumitru, Jacquelyn J Bower, Swati Yadav, Matthew H Porteus, Larysa H Pevny, R Jude Samulski
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27520 (2011)
Human embryonic stem cells (hESCs) are primed for rapid apoptosis following mild forms of genotoxic stress. A natural form of such cellular stress occurs in response to recombinant adeno-associated virus (rAAV) single-strand DNA genomes, which exploi
Externí odkaz:
https://doaj.org/article/6b2d319413ca4e23aec775a8396b5dae
Autor:
F Curtis Hewitt, R Jude Samulski
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8850 (2010)
While the molecular mechanisms of DNA-protein specificity at the origin of replication have been determined in many model organisms, these interactions remain unknown in the majority of higher eukaryotes and numerous vertebrate viruses. Similar to ma
Externí odkaz:
https://doaj.org/article/e474fa07b58c4da4a1bfadb1c07dae35
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7705 (2009)
Adeno-associated virus (AAV) transduction initiates a signaling cascade that culminates in a transient DNA damage response. During this time, host DNA repair proteins convert the linear single-strand AAV genomes to double-strand circular monomers and
Externí odkaz:
https://doaj.org/article/ced70848fb534af0a50606d536806e4f
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101211- (2024)
Intra-articular adeno-associated virus (AAV) gene therapy has been explored as a potential strategy for joint diseases. However, concerns of low transduction efficacy, off-target expression, and neutralizing antibodies (Nabs) still need to be address
Externí odkaz:
https://doaj.org/article/6b63d18ea2c14b95ade6ad56c358ead2