Zobrazeno 1 - 10
of 123
pro vyhledávání: '"R John, Mayer"'
Autor:
Jing Fang, Megan T. Lewno, Huabo Su, Taixing Cui, Nirmal Parajuli, Wenjuan Wang, Jianqiu Zou, Penglong Wu, Bo Pan, Jinbao Liu, R. John Mayer, Zongwen Tian, Xuejun Wang, Lynn Bedford, Jie Li
Publikováno v:
Autophagy
Rationale: The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway are pivotal to proteostasis. Targeting these pathways is emerging as an attractive strategy for treating cancer. However, a significant proportion of patients who r
Autor:
Csaba Ádori, Gábor G. Kovács, Péter Lőw, Kinga Molnár, Carlos Gorbea, Erzsébet Fellinger, Herbert Budka, R. John Mayer, Lajos László
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 3, Pp 427-435 (2005)
Creutzfeldt–Jakob (CJD) and Alzheimer disease (AD) are accompanied by selective neuronal loss in the brain. We examined the regional and subcellular immunolocalization of ubiquitin, proteasomal subunits, and the heat-shock protein Hsp72 in control,
Externí odkaz:
https://doaj.org/article/ce1596d17fd247059eaa0c5ec8830533
Autor:
Simon M L Paine, Glenn Anderson, Karen Bedford, Karen Lawler, R John Mayer, James Lowe, Lynn Bedford
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54711 (2013)
Parkinson's disease (PD) is characterized by the progressive degeneration of substantia nigra pars compacta (SNpc) dopaminergic neurones and the formation of Lewy bodies (LB) in a proportion of the remaining neurones. α-synuclein is the main compone
Externí odkaz:
https://doaj.org/article/a72655997996431aab745e72983c18c0
Autor:
Xuejun Wang, Jing Fang, R. John Mayer, Bo Pan, Lynn Bedford, Megan T. Lewno, Nirmal Parajuli, Penglong Wu, Huabo Su, Zongwen Tian, Jinbao Liu, Taixing Cui, Jie Li
RationaleThe ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway (ALP) are pivotal to proteostasis. Targeting these pathways is emerging as an attractive strategy for treating cancer. However, a significant proportion of patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02722129be154703e66cb353161e6bd8
https://doi.org/10.1101/2019.12.27.889519
https://doi.org/10.1101/2019.12.27.889519
Autor:
Aslihan, Ugun-Klusek, Michael H, Tatham, Jamal, Elkharaz, Dumitru, Constantin-Teodosiu, Karen, Lawler, Hala, Mohamed, Simon M L, Paine, Glen, Anderson, R, John Mayer, James, Lowe, E, Ellen Billett, Lynn, Bedford
Publikováno v:
Cell Death & Disease
The ubiquitin–proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS
Publikováno v:
Neuroscience Letters. 521:130-135
The ubiquitin proteasome system (UPS) is a fundamental cellular pathway, degrading most unwanted intracellular soluble proteins. Dysfunction of the UPS has been associated with normal aging as well as various age-related pathological conditions, incl
Autor:
Simon Dawson, Kelli Baalman, Khosrow Rezvani, R. John Mayer, Mariella De Biasi, Yanfen Teng, Maureen Mee, Hongmin Wang
Publikováno v:
J Neurochem
J. Neurochem. (2012) 122, 24–37. Abstract The metabotropic glutamate receptors (mGluRs) fine-tune the efficacy of synaptic transmission. This unique feature makes mGluRs potential targets for the treatment of various CNS disorders. There is ample e
Publikováno v:
Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, Second Edition
The distinguishing feature of idiopathic chronic neurodegenerative disease is its relationship to age. Even in familial disease, clinical symptoms emerge in later life. The diseases are associated with intraneuronal misfolded proteins. This implies t
Autor:
James Lowe, Simon M. L. Paine, Lynn Bedford, Paul W. Sheppard, R. John Mayer, Julian R. Thorpe, James R. Cavey, Robert Layfield, Nin Bajaj
Publikováno v:
Neuroscience Letters. 460:205-208
The major human neurodegenerative diseases are characterised by ubiquitin-positive intraneuronal inclusions, however the precise nature of the ubiquitin modifications in these structures is unclear. Using a monoclonal antibody specific for Lys63-link
Publikováno v:
Autophagy. 5:224-227
In the past twenty years, evidence has accumulated to show that ubiquitinated proteins are a consistent feature of the intraneuronal protein aggregates (inclusions) that characterize chronic neurodegenerative disease. These findings may indicate that