Zobrazeno 1 - 10
of 62
pro vyhledávání: '"R Jeremy Nichols"'
Autor:
Spencer B Hermanson, Coby B Carlson, Steven M Riddle, Jing Zhao, Kurt W Vogel, R Jeremy Nichols, Kun Bi
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43580 (2012)
Mutations in the leucine-rich repeat kinase-2 (LRRK2) have been linked to Parkinson's disease. Recent studies show that inhibition of LRRK2 kinase activity decreased the level of phosphorylation at its own Ser910 and Ser935, indicating that these sit
Externí odkaz:
https://doaj.org/article/6312974e5373462aa4657fa85fc72947
Autor:
Lucia Iannotta, Marco Emanuele, Giulia Favetta, Giulia Tombesi, Laurine Vandewynckel, Antonio Jesús Lara Ordóñez, Jean-Michel Saliou, Matthieu Drouyer, William Sibran, Laura Civiero, R. Jeremy Nichols, Panagiotis S. Athanasopoulos, Arjan Kortholt, Marie-Christine Chartier-Harlin, Elisa Greggio, Jean-Marc Taymans
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of inherited and sporadic Parkinson’s disease (PD) and previous work suggests that dephosphorylation of LRRK2 at a cluster of heterologous phosphosites is associated to disease. W
Externí odkaz:
https://doaj.org/article/5c7b59f9a8734bce82374910d2ad476b
Autor:
Capria Rinaldi, Christopher S. Waters, Zizheng Li, Karl Kumbier, Lee Rao, R. Jeremy Nichols, Matthew P. Jacobson, Lani F. Wu, Steven J. Altschuler
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112447- (2023)
Summary: Parkinson’s disease-causing leucine-rich repeat kinase 2 (LRRK2) mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations—which do not affect intrinsic kinase activity—lead t
Externí odkaz:
https://doaj.org/article/96865a93efde46f3a41eee3b34861ca1
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/31373fb702a44d3084ffa95d848e189a
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/caaf6fb89b3942219c4fd4647607c897
Autor:
Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Réginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugénie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-François Bodart, Marie-Christine Chartier-Harlin, Veerle Baekelandt, R. Jeremy Nichols, Jean-Marc Taymans
Publikováno v:
Neurobiology of Disease, Vol 157, Iss , Pp 105426- (2021)
LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD). Dephosphorylation at LRRK2's S910/S935/S955/S973 phosphosite cluster is observed in several con
Externí odkaz:
https://doaj.org/article/1fd99d9a1cef4426b7f99882df3c1bd9
Autor:
Capria Rinaldi, Christopher S. Waters, Karl Kumbier, Lee Rao, R. Jeremy Nichols, Matthew P. Jacobson, Lani F. Wu, Steven J. Altschuler
Parkinson’s disease-causing LRRK2 mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations—which do not affect intrinsic kinase activity—lead to higher levels of cellular Rab phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abd4c07a6f724caa62b514c105245a99
https://doi.org/10.1101/2022.10.25.513743
https://doi.org/10.1101/2022.10.25.513743
Autor:
Robert K. Leśniak, R. Jeremy Nichols, Marcus Schonemann, Jing Zhao, Chandresh R. Gajera, Grace Lam, Khanh C. Nguyen, J. William Langston, Mark Smith, Thomas J. Montine
Publikováno v:
European journal of medicinal chemistry. 242
Mutations in the Leucine Rich Repeat Protein Kinase 2 gene (LRRK2) are genetic predispositions for Parkinson's Disease, of which the G2019S (GS) missense mutation is the most common. GS-LRRK2 has a hyperactive kinase, and although numerous drug disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afa298b16b52ef5c74636de19c67d88
https://pubmed.ncbi.nlm.nih.gov/36049274
https://pubmed.ncbi.nlm.nih.gov/36049274
Autor:
Belén Fernández, Vinita G. Chittoor-Vinod, Jillian H. Kluss, Kaela Kelly, Nicole Bryant, An Phu Tran Nguyen, Syed A. Bukhari, Nathan Smith, Antonio Jesús Lara Ordóñez, Elena Fdez, Marie-Christine Chartier-Harlin, Thomas J. Montine, Mark A. Wilson, Darren J. Moore, Andrew B. West, Mark R. Cookson, R. Jeremy Nichols, Sabine Hilfiker
Publikováno v:
Journal of Parkinson's disease. 12(5)
Background: Coding variation in the Leucine rich repeat kinase 2 gene linked to Parkinson’s disease (PD) promotes enhanced activity of the encoded LRRK2 kinase, particularly with respect to autophosphorylation at S1292 and/or phosphorylation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10af0e80930f25357884168ba17e3e8d
https://pubmed.ncbi.nlm.nih.gov/35599495
https://pubmed.ncbi.nlm.nih.gov/35599495
Autor:
Robert K. Leśniak, R. Jeremy Nichols, Marcus Schonemann, Jing Zhao, Chandresh R. Gajera, Grace Lam, Khanh C. Nguyen, J. William Langston, Mark Smith, Thomas J. Montine
Publikováno v:
ACS Med Chem Lett
[Image: see text] G2019S (GS) is the most prevalent mutation in the leucine rich repeat protein kinase 2 gene (LRRK2), a genetic predisposition that is common for Parkinson’s disease, as well as for some forms of cancer, and is a shared risk allele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75edb524222030a37a7cce5cca6241aa
https://europepmc.org/articles/PMC9190033/
https://europepmc.org/articles/PMC9190033/