Zobrazeno 1 - 10
of 28
pro vyhledávání: '"R Jeffrey, Neitz"'
Autor:
Alan R. Wolfe, R. Jeffrey Neitz, Mark Burlingame, Brian M. Suzuki, KC Lim, Mark Scheideler, David L. Nelson, Leslie Z. Benet, Conor R. Caffrey
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 571-586 (2018)
Treatment of schistosomiasis relies precariously on just one drug, praziquantel (PZQ). In the search for alternatives, 15 S-[2-(alkylamino)alkane] thiosulfuric acids were obtained from a previous research program and profiled in mice for efficacy aga
Externí odkaz:
https://doaj.org/article/7ed64300428e4730a8f663a65ab0444e
Autor:
Dyana N. Kenanova, Emira J. Visser, Johanna M. Virta, Eline Sijbesma, Federica Centorrino, Holly R. Vickery, Mengqi Zhong, R. Jeffrey Neitz, Luc Brunsveld, Christian Ottmann, Michelle R. Arkin
Publikováno v:
ACS Central Science, 9(5), 937-946. American Chemical Society
ACS central science, vol 9, iss 5
ACS central science, vol 9, iss 5
Protein-protein interactions (PPIs) are responsible for the proper function of biological processes and, when dysregulated, commonly lead to disease. PPI stabilization has only recently been systematically explored for drug discovery despite being a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5dfbb9f85f0ba6a6dbf92e3bacf2b
https://research.tue.nl/nl/publications/076d1025-cb55-4575-b0a2-584f109c7743
https://research.tue.nl/nl/publications/076d1025-cb55-4575-b0a2-584f109c7743
Autor:
Stefan Gahbauer, Galen J. Correy, Marion Schuller, Matteo P. Ferla, Yagmur Umay Doruk, Moira Rachman, Taiasean Wu, Morgan Diolaiti, Siyi Wang, R. Jeffrey Neitz, Daren Fearon, Dmytro Radchenko, Yurii Moroz, John J. Irwin, Adam R. Renslo, Jenny C. Taylor, Jason E. Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K. Shoichet, James S. Fraser
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 2
The nonstructural protein 3 (NSP3) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains a conserved macrodomain enzyme (Mac1) that is critical for pathogenesis and lethality. While small molecule inhibitors of Mac1 have great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991faf3ec537a19849a09bb30d7edb38
https://pubmed.ncbi.nlm.nih.gov/36598939
https://pubmed.ncbi.nlm.nih.gov/36598939
Autor:
Stefan, Gahbauer, Galen J, Correy, Marion, Schuller, Matteo P, Ferla, Yagmur Umay, Doruk, Moira, Rachman, Taiasean, Wu, Morgan, Diolaiti, Siyi, Wang, R Jeffrey, Neitz, Daren, Fearon, Dmytro, Radchenko, Yurii, Moroz, John J, Irwin, Adam R, Renslo, Jenny C, Taylor, Jason E, Gestwicki, Frank, von Delft, Alan, Ashworth, Ivan, Ahel, Brian K, Shoichet, James S, Fraser
Publikováno v:
bioRxiv : the preprint server for biology.
The nonstructural protein 3 (NSP3) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains a conserved macrodomain enzyme (Mac1) that is critical for pathogenesis and lethality. While small molecule inhibitors of Mac1 have great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0d1f125f48c87de315a09265cca538b
https://pubmed.ncbi.nlm.nih.gov/35794891
https://pubmed.ncbi.nlm.nih.gov/35794891
Autor:
Thavy Long, R Jeffrey Neitz, Rachel Beasley, Chakrapani Kalyanaraman, Brian M Suzuki, Matthew P Jacobson, Colette Dissous, James H McKerrow, David H Drewry, William J Zuercher, Rahul Singh, Conor R Caffrey
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004356 (2016)
BACKGROUND:Schistosoma flatworm parasites cause schistosomiasis, a chronic and debilitating disease of poverty in developing countries. Praziquantel is employed for treatment and disease control. However, its efficacy spectrum is incomplete (less act
Externí odkaz:
https://doaj.org/article/1f31106f26284b5db634a718d8bb99bb
Autor:
Shilpi Khare, Steven L Roach, S Whitney Barnes, Dominic Hoepfner, John R Walker, Arnab K Chatterjee, R Jeffrey Neitz, Michelle R Arkin, Case W McNamara, Jaime Ballard, Yin Lai, Yue Fu, Valentina Molteni, Vince Yeh, James H McKerrow, Richard J Glynne, Frantisek Supek
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1005058 (2015)
Unbiased phenotypic screens enable identification of small molecules that inhibit pathogen growth by unanticipated mechanisms. These small molecules can be used as starting points for drug discovery programs that target such mechanisms. A major chall
Externí odkaz:
https://doaj.org/article/74c1eaf7a3e241ef97a84b81f3a2894a
Autor:
Mark A. Burlingame, David Lee Nelson, R. Jeffrey Neitz, Alan R. Wolfe, Brian M. Suzuki, K. C. Lim, Leslie Z. Benet, Mark A. Scheideler, Conor R. Caffrey
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 571-586 (2018)
International journal for parasitology. Drugs and drug resistance, vol 8, iss 3
International Journal for Parasitology: Drugs and Drug Resistance
International journal for parasitology. Drugs and drug resistance, vol 8, iss 3
International Journal for Parasitology: Drugs and Drug Resistance
Treatment of schistosomiasis relies precariously on just one drug, praziquantel (PZQ). In the search for alternatives, 15 S-[2-(alkylamino)alkane] thiosulfuric acids were obtained from a previous research program and profiled in mice for efficacy aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8571431547e2babe3cffa7de089f3348
http://www.sciencedirect.com/science/article/pii/S221132071830109X
http://www.sciencedirect.com/science/article/pii/S221132071830109X
Autor:
R. Jeffrey Neitz, Zhizhou Yue, Neal Jeffrey Green, Shan Li, Stacie L. Bulfer, Tsui-Fen Chou, Raffaele Colombo, James C. Burnett, Matthew G. LaPorte, Peter Wipf, Donna M. Huryn, Michelle R. Arkin, Celeste Alverez, William J. Moore
Publikováno v:
ACS medicinal chemistry letters, vol 9, iss 11
ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters
Optimization of the side-chain of a phenyl indole scaffold identified from a high-throughput screening campaign for inhibitors of the AAA+ ATPase p97 is reported. The addition of an N-alkyl piperazine led to high potency of this series in a biochemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a97309d2f36bd3f55226152fc25aff
https://doi.org/10.1021/acsmedchemlett.8b00372
https://doi.org/10.1021/acsmedchemlett.8b00372
Autor:
Jonathan A. Ellman, Estefania Hugo Caselli, Hai-Chao Xu, Somenath Chowdhury, Clifford Bryant, Steven Chen, Servando Ponce, Michelle R. Arkin, R. Jeffrey Neitz, Jiri Gut, Adam R. Renslo
Publikováno v:
Bioorganic & medicinal chemistry letters, vol 25, iss 21
Inhibition of the cysteine protease cruzain from Trypanosoma cruzi has been studied pre-clinically as a new chemotherapeutic approach to treat Chagas’ disease. Efficacious effects of vinylsulfone-based cruzain inhibitors in animal models support th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e40868b31dc6a459de196e31f2fb4b
https://doi.org/10.1016/j.bmcl.2015.06.066
https://doi.org/10.1016/j.bmcl.2015.06.066
Autor:
James H. McKerrow, R. Jeffrey Neitz, Jiri Gut, Adam R. Renslo, Michelle R. Arkin, Danielle Kellar, Frantisek Supek, Valentina Molteni, Stephanie A. Robertson, Alejandra Gallardo-Godoy, Steven Chen, Jair L. Siqueira-Neto, Vince Yeh, Richard Glynne, Steven L. Roach, Clifford Bryant, Arnab K. Chatterjee
Publikováno v:
SLAS Discovery. 20:101-111
Chagas disease affects 8 million people worldwide and remains a main cause of death due to heart failure in Latin America. The number of cases in the United States is now estimated to be 300,000, but there are currently no Food and Drug Administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe87b7f6b3b7366cba4100e54ca8f43
https://doi.org/10.1177/1087057114553103
https://doi.org/10.1177/1087057114553103